6IYC


Conserved Protein Domain Family
APP_amyloid
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pfam10515: APP_amyloid (this model, PSSM-Id:371108 is obsolete and has been replaced by 463129)
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beta-amyloid precursor protein C-terminus
This is the amyloid, C-terminal, protein of the beta-Amyloid precursor protein (APP) which is a conserved and ubiquitous transmembrane glycoprotein strongly implicated in the pathogenesis of Alzheimer's disease but whose normal biological function is unknown. The C-terminal 100 residues are released and aggregate into amyloid deposits which are strongly implicated in the pathology of Alzheimer's disease plaque-formation. The domain is associated with family A4_EXTRA, pfam02177, further towards the N-terminus.
Links
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Statistics
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PSSM-Id: 371108
Aligned: 20 rows
Threshold Bit Score: 63.1319
Created: 2-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6IYC_E        30 IVITLVMLKKK-QYTSIHHGVVEVDA------AVTP---EERHLSKMQQNGYENPTYKFFE 80  human
EEC20286     232 lLVGAVLLRRQaQRSPQAQGFVQVDQga---lPASP---EERHLASMQVNGYENPTYKYFE 286 black-legged tick
ESO01307     847 IIAGVMIMRRRaAVSKQQHKILPTEPvig-dlVTSP---EESHVMNMQVNGYENPTYKYFE 903 Helobdella robusta
EKC30441     122 IIVAIVMLRKRsHRHPVTHGFAEMDP------AASP---EERHVANMQMNGYENPTYKYFE 173 Pacific oyster
5_pfamImport   1 AVVSMILRNRR-----STPNVVRINE------NVDDltqDEKQLLQMQHNGYENPTYKYLE 50 
EDO45291     525 IIVAMAMRRSRg---SSATKTVLVDPd-------aDgnsEKQRLTDLQENGYENPTYKFYD 575 starlet sea anemone
ADM32510     631 ACVALAVARRRd-RAPQAQGFVQVEQtg--vvAPTP---EERHVANMQINGYENPTYKYFE 685 domestic silkworm
ESO02402     537 IVVGVLIMRRRgNGFYSNNGRMEGERaendalNVSP---EEQHVASMQVNGYENPTYKYFE 594 Helobdella robusta
XP_015363931 679 ICVGVAVIRRRnARLPQNQGFIEVDQ------GISQ---EERHVANMQINGYENPTYKYFE 730 Russian wheat aphid
NP_508870    637 IAFAITNARRRr----AMRGFIEVD-------VYTP---EERHVAGMQVNGYENPTYSFFD 683 Caenorhabditis elegans
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