6J8E,6J8G


Conserved Protein Domain Family
Na_trans_cytopl

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pfam11933: Na_trans_cytopl (this model, PSSM-Id:371806 is obsolete and has been replaced by 403218)
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Cytoplasmic domain of voltage-gated Na+ ion channel
This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.
Statistics
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PSSM-Id: 371806
View PSSM: pfam11933
Aligned: 39 rows
Threshold Bit Score: 86.6835
Threshold Setting Gi: 0
Created: 2-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6J8E_A              557 SGE-Eek--nDRVRKSese-dsiRRKGFRfSLEgsRLTYe-kRFSSphqSLLSIRgsl---fspRRNSRAS-LFSFR--- 624  human
EEB14510            445 SIQ-Seg--gDSISEQ-------RSR---------LNATkfrKVSA---TSLSLPgsp---fnvRRSSRGShQFTVRngt 499  human b...
Q16Z69              473 SIR-Seg--lESVSEI-------TRTTAPtATA--AGTAkarKVSA---ASLSLPgsp---fnlRRGSRGShQFTIRn-- 532  yellow ...
FlyBase:CG9907-PBE  509 SIR-SvevesESVSVI-------QRQPAPtTA---HQATkvrKVST---TSLSLPgsp---fniRRGSRSShKYTIRn-- 569  fruit fly
ELK25139            426 SSE-TeecgdDRLPKSdsd-dgpRAM-----------------------NHLGNTqgfnrtsvkSHFRRGS-IFTFR--- 476  Myotis ...
NP_001153633        483 SSG-TeecgeDRLPKSdse-dgpRAM-----------------------NHLSLTrglsrtsmkPRSSRGS-IFTFR--- 533  human
XP_012820423        485 SET-EeygedMKPPRGemdeeslRKM-----------------------SILGIGfgpg--sgkRRISQGS-IFNFR--- 534  tropica...
KFZ69242            150 SLGtEeygedQRNPKCdyd-dgqRRM-----------------------TLLGISygpsanlvkRRTSHGS-IFSFR--- 201  great c...
XP_019650094        483 SSG-TeecgdDRFPKSdse-dgpRAM-----------------------NHLSSIhglsrtsmkPRSSRGS-IFTFR--- 533  giant p...
NP_001233256        482 SSG-TdeggeDRFPKSdsd-dgpRRTrsgaglaeart--qppppslppqALLGVNhaplrsslkRRSSHGS-VFTFR--- 553  gray sh...
6J8E_A              625 GRAK------------------DIGSEndfaddehsTFEDNDsRRDSLfvPHrhg---errHSNVSQAsrasrvlpilpm 683  human
EEB14510            500 GRGRfvgpptgdrkplvlstylDAQEHlpyaddsnaVTPMSE-ENGAMvvPMfyanlgsrhSSYTSHAsrmsytshgdl- 577  human b...
Q16Z69              533 GRGRfvgvpgsdrkplvlstylDAQEHlpyaddsnaVTPMSE-ENGAIivPVyyanlgsrhSSYTSHQsrisyts----- 606  yellow ...
FlyBase:CG9907-PBE  570 GRGRfgipgsdrk-plvlstyqDAQQHlpyaddsnaVTPMSE-ENGAIivPVyygnlgsrhSSYTSHQsrisytshgdl- 646  fruit fly
ELK25139            477 RR--------------------DTGSEtdfaddensTAGDSEsHRTSLlvPWsl-----rrPSAQPQPspgtsapghaln 531  Myotis ...
NP_001153633        534 RR--------------------DLGSEadfaddensTAGESEsHHTSLlvPWpl-----rrTSAQGQPspgtsapghalh 588  human
XP_012820423        535 FRNR------------------DLCSEtefaddevsNA--SDgHRGSLlvPRag-----rrQSTQSQTsplsfantpgyt 589  tropica...
KFZ69242            202 LRGR------------------DTGSEtdfaddeisTAGENEsHRGSLliPRsg-----rrPSVQSQVshsshpttpnyt 258  great c...
XP_019650094        534 RR--------------------DLGSEtdfaddensTAGDSEsHHTSLlvPWpl-----rrPSAQGQLspgtsapghaln 588  giant p...
NP_001233256        554 RR--------------------DLGSEtdfaddeisTPGESEsHRASLlvPWpa-----rrPSGQSQPspgvpgvpsllh 608  gray sh...
6J8E_A              684 ngkmhsavdcn------------------gvvslvggpstltsagqllpegTTTETE-IRKrRSSS-------------- 730  human
EEB14510            578 -----------------------------------------lgsfggngkgRTKESQ-LRD-RNRAlrcsqrglpiteqp 614  human b...
Q16Z69              607 --------------------------------------------hgdllggMTKESR-LRN-RSARntnhsivpppnmsg 640  yellow ...
FlyBase:CG9907-PBE  647 ----------------------------------------lggmavmgvstMTKESK-LRN-RNTRnqsvgatnggttcl 684  fruit fly
ELK25139            532 gkrnstidcngvvsll--------gagdpeatspgsrllrpmmlerppdttTPSEEP-GRPqMLTP-------------- 588  Myotis ...
NP_001153633        589 gkknstvdcngvvsll--------gagdpeatspgshllrpvmlehppdttTPSEEP-GGPqMLTS-------------- 645  human
XP_012820423        590 qngkrnssvdcngvvslvg--gagtysnptspgglllpaviveksgaeenaSPTDLElSRMqLLMP-------------- 653  tropica...
KFZ69242            259 qtgkrnssvdcngvvsligggtgalnpdptspaglllppvimekpgtgdltSPSDEA-SKKqLLMP-------------- 323  great c...
XP_019650094        589 gkrnstvdcngvvsll--------gtgdaeatspgshllrpvildrppdttTPSEEP-GRPqMLNP-------------- 645  giant p...
NP_001233256        609 ngkrnsavdcngvvslla----srvpeaaspggsllssvilekprpppdttSVSEEV-SKKqLLMP-------------- 669  gray sh...
6J8E_A              731 -----------------------------YHVSMDLLEDPTSRQRAMS 749  human
EEB14510            615 tsk---------freieenedgnckekyrRQSDNPFIE-PMHNQPTVD 652  human body louse
Q16Z69              641 pnmsyvdsnhkgqrdfdmsqdctdeagkiKHNDNPFIE-PSqtqtvvd 687  yellow fever mosquito
FlyBase:CG9907-PBE  685 dtnhk-----ldhrdyeiglectdeagkiKHHDNPFIEpvqtqtvvdm 727  fruit fly
ELK25139            589 -----------------------------PARCMDGFEGPGERQRALS 607  Myotis davidii
NP_001153633        646 -----------------------------QAPCVDGFEEPGARQRALS 664  human
XP_012820423        654 -----------------------------HALSVEYVDQPFQRQRAVS 672  tropical clawed frog
KFZ69242            324 -----------------------------HRPSVDHSDEPFQRQRAVS 342  great crested grebe
XP_019650094        646 -----------------------------QAPCMDGFEEPGERQRALS 664  giant panda
NP_001233256        670 -----------------------------QRLSLEYFEEPHERQRALS 688  gray short-tailed opossum
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