Conserved Protein Domain Family
Defensin_big
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pfam14862: Defensin_big 
Big defensin
Big defensins are antimicrobial peptides. They consist of a hydrophobic N-terminal half, which is active against Gram-positive bacteria, and a cationic C-terminal half, which is active against Gram-negative bacteria. The C-terminal half adopts a beta-defensin-like structure.
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Statistics
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PSSM-Id: 373348
Aligned: 5 rows
Threshold Bit Score: 47.6183
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EKC19784  75 MTVGAPLFLALVAAYGIYAVTRYAIKkaer----------------vsdkDNHACGRGIGWCRPKcfpgehldwddpllC 138
EEP75553   1 MKFSGYLCVLFGAVFVAAAPVTQADN------------------------DTPTPGKDREFCKAK--------------C 42 
Q8K3I8     1 MR----LALLLLAILVATELVVSGKN------------------------PILQCMGNRGFCRSS--------------C 38  house mouse
Q32ZG8     1 MK----LVLLLLAIFVTTELVMSGKN------------------------PTLQCMGNRGFCRPS--------------C 38  Norway rat
EFX71545  66 LKVAPSIYRWMNGLYGGAAVTRIGVTvaegpspslerrvpccsgyltptmDARNCTKMGGEC-----------------C 128

EKC19784 139 GSY------YCCMP 146
EEP75553  43 KKDhaemveYCKTL 56 
Q8K3I8    39 KKSeqa-yfYCRTF 51  house mouse
Q32ZG8    39 KKGeqa-yfYCRTY 51  Norway rat
EFX71545 129 SRE------FTDYP 136
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