6NT5,6NT6


Conserved Protein Domain Family
TMEM173
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pfam15009: TMEM173 (this model, PSSM-Id:373471 is obsolete and has been replaced by 464441)
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Transmembrane protein 173
Transmembrane protein 173, also known as stimulator of interferon genes protein (STING), is a transmembrane adaptor protein which is involved in innate immune signalling processes. It induces expression of type I interferons (IFN-alpha and IFN-beta) via the NF-kappa-B and IRF3, pathways in response to non-self cytosolic RNA and dsDNA.
Links
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Statistics
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PSSM-Id: 373471
Aligned: 32 rows
Threshold Bit Score: 258.314
Created: 25-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6NT5_A               46 YLVLHLASLQLGLLLNGVCSLAEE-LRHIHSRYRGS-YWRTVRACLGCPLRRGALLLLSIYFYYSLPN------------ 111 human
A7SLZ2               59 TFSLAYLAFLVGELLRRCCLFAEE-YRHIETRYNGS-LKKAIQTTFSFGHNNVLFVASLLFFVVFVASndpngsssviqg 136 starlet ...
WGS:AAQB:GK20640-PA  33 TVVRIVITISLADLLQRVFLSAYEyIWNPRFYLPDErFWTILRRTHTYSNKHVYLMLAFGCLGLARFGvt---------- 102 Drosophi...
WGS:AAPP:GF11767-PA  39 vsirvvATVFLADFLQRLFRCVVEyIRYSRYYLPEDrLWTILRRGCTYESKHIYLAMAFVIAGLSRISvt---------- 108 Drosophi...
EDW47162              8 TSVRIVATVFLADLLRRLYHCVIEyGSNGRYYLPEDrLWVILRRSCTYNNRSIYLIVGFVLVAFFRISvtgnyrdvvptt 87  Drosophi...
WGS:AAPU:GI18829-PA  26 yavriCIVIFVADLLQRLFFVFKEyLCHRIYYLPEDrLTTIIKRAYTYNIKTVYLALLVIFTGLTRFG------------ 93  Drosophi...
EDW01242              8 TCVRILIVIFVADFMQRLSYALAEyFLYGNHYLLEErLLTILRRAFTYNSKTICLTFGIMFLGFARFGrtgnlnqllpsc 87  Drosophi...
EFZ11711             48 VTSVFVEAFLICDLILRLCQTVIS-ITDVDQQSRES-FWSMAKDYFTLNTASVTIFVISTLLCFCLSItirtcp------ 119 red fire...
EGI57896             49 VASVFLVIFLLCDVTLRLCQTLISfTTNVNQHSEES-FWSVAKYHFSLNTLSATIIIIAALLFLGLSItirgcp------ 121 Panamani...
EFN63910             25 TTSVFLVIFLLCDVMLHLCQTVIS-LTNMDPRSRQS-FSSIISYYFILNIASAVVVLIGVFLFLITSTtivrec------ 96  Florida ...

6NT5_A              112 ------------AVGPPFTWMLALLGl-------SQALNIL--LGLKGLAPAEISAVcekGNFNVAHGLAWSYYIGYLRL 170 human
A7SLZ2              137 nstaephtemrqTSGWQGLWGQFIISal-----lTPLVVHL--LGLRELSKVEESQLnekENKNVADGLAWSYYFGYLKF 209 starlet ...
WGS:AAQB:GK20640-PA 103 -----------gNL-KPILPSAMYLAc-------MPLYWLF--NDLGESTLSYANWVrdtHGLDYASGMASSYFHGYLNL 161 Drosophi...
WGS:AAPP:GF11767-PA 109 -----------gDFTVVIPTALYLAQ--------IPLYWLF--FDLSQSTLTYSHWIrenHGLDYAAGMASNYFHGYLKL 167 Drosophi...
EDW47162             88 lflvhmplywiwSF-----------------------------SDMDHSTLSYSHWIrdsHGLDYAAGMASNYFHGYLKL 138 Drosophi...
WGS:AAPU:GI18829-PA  94 ------------RTN-----NLALLLprgeplllIPLYWIFtyVQLSHSSLSYAHWIrdsHGLDYAAGMASSYFHGYLKL 156 Drosophi...
EDW01242             88 sdfaymplywiyIY-----------------------------AQMSQSSLSYAHWIrdaHGLDYAAGMASNYFHGYLKL 138 Drosophi...
EFZ11711            120 -------lnyvwDFGPEVGLSMMIFSf-------CLLTRICnlADWEKRSLSDLSVM---KGLDYGTGMAYSFYYGYLRL 182 red fire...
EGI57896            122 -------lryawDFGPYMCVPLMIFS--------FCLVRMSnlAEWETGSLSDLNIM---KGLDYGTGMAYNFYYGYLRL 183 Panamani...
EFN63910             97 ------plshvwDFGPDVYVPSMIFS--------FYLLKITdlAKRERGPLLDLDIM---KGLDYGTGMAYSFYYGYLQL 159 Florida ...

6NT5_A              171 ILPE--------LQARIRTYNQHYNNllrGAVSQRLYILLPLDCGVPDNLSMAD----PNIRFLDKLPQQTGDRAGIKDR 238 human
A7SLZ2              210 VLPE--------LEKQIEKTSKFRSK---EKFVKKMFILIPSNCFWDDKIPGSDydpqNRITFEGNTEPLEKTRGGVFLR 278 starlet ...
WGS:AAQB:GK20640-PA 162 ALPDrsd---dgLQHRMRRYEDSHNV---TFGVHRLIILIPDEMWVGGRIN--S----DLLEPAQPLETININRAGVKGR 229 Drosophi...
WGS:AAPP:GF11767-PA 168 ALPDtkd---dgLKHRMAVYEAKNNV---TFGVDRLIILCPDEMFVEKKLENNS----TLLDKAEPLETKYLHRAGVH-R 236 Drosophi...
EDW47162            139 SLPErkd---dgLKQRMEMYEDKNNV---TFGIKRLVILIPDEMFVNGVLE--S----HLLDKAEPLETQFINRAGVY-R 205 Drosophi...
WGS:AAPU:GI18829-PA 157 SLPEren---dgLQKRMEKYEDMQNV---KFGIKRLIILIPDEMFVNRVIQ--S----EWLDKAEPLETQFINRAGVN-R 223 Drosophi...
EDW01242            139 SLPArng---egLQQRMTDYEDSQNV---KFGLRRLIILVPDEMFVKGLID--S----PLFEKAKPLETHFINRAGVN-R 205 Drosophi...
EFZ11711            183 ILPStetg-rkgIIEKIETFEANHNI---TFPVHKLFLLIPSSGYIPPDLKEASy---QWMESTSNLEEEERNRAGNIGR 255 red fire...
EGI57896            184 TLPSsetg-kkgIIEKIENFEDYHNV---TFPVHKLFLLIPSSGYIPPDLKEASc---QWMENIHELEEEKRNRAGNIGR 256 Panamani...
EFN63910            160 ILPNrgttdsksIIEKIENFEDKHEV---TFPVHKLFILIPSSGYISPHLKEMSd---QWMEIAGELEEEKRDRAGLRGK 233 Florida ...

6NT5_A              239 VYSNSIYEL----LENGQRAGTCVLEYATPLQTLFAMSQYSQAG--FSREDRLEQAKLFCRTLEDILADAPESQNNCRLI 312 human
A7SLZ2              279 HYKHSVYEI----KDGENEPWFCIMEYATPLLTLYDMSVAQPGE--LSREERDAQVVVFLRKLQDILEGDRACQGKYELV 352 starlet ...
WGS:AAQB:GK20640-PA 230 PYKIAVYRLn---RKINGKYYYFALEGATPMLSFFESIQSNLSAtwYMRELKREIWLKFSAHLKNLLTTWPETRGKVELL 306 Drosophi...
WGS:AAPP:GF11767-PA 237 PFKHDVYRLn---KKIDGKTYYFAMEGATPMLSFFDAMESNLSAtwQMKELKREIWLKFCKHLKHLIETWPETRNEVDLL 313 Drosophi...
EDW47162            206 PFKHAVYRMn---KKVNGRTYYFAIEGATPLISFFDAIYSNLSAtwQMQELKREIWLKFYKHLRELITTWPETRDLIELI 282 Drosophi...
WGS:AAPU:GI18829-PA 224 PFKHAVYRLn---KQINGTTYYFAMEGATPMLTFFESMHFQLSAtwQMQEMKREIWLKFCKHLQELLNNWPETRREVQLI 300 Drosophi...
EDW01242            206 PFKHDVYRLn---RKINNTSYYFAIEGATPMLSFFDAMHHQLSAtwQMQEMKREIWLKFCKHLKGLLSTWPETRNEVELI 282 Drosophi...
EFZ11711            256 IYLNSAYKIyldgRNSGNDPVYAVVEGASPLLTYHEVLQHNHPEssVYKRYKSKIIERFYTKLLETLQSNPETRDLCELI 335 red fire...
EGI57896            257 TYRNNAYKIypggRKLGNKPIYIVVEGATPLLTYYEVQKHNHPEsaIYKQYKSKIIEKFYTKLQEILQSNPETRDLCELI 336 Panamani...
EFN63910            234 TYHNNVYKIypngRNSGASPIYVVAEGATTLLTFYEVQQHSHPEsiVYKQYKNEITMMFYKKLAEILESEPTTKNLCELI 313 Florida ...

6NT5_A              313 AYQEP-AddSSFSLSQEVLRHLRQEE 337 human
A7SLZ2              353 TFSpDrD------LADVMLRKLKDSE 372 starlet sea anemone
WGS:AAQB:GK20640-PA 307 MYNSLdDngNAIDVGELVIAQMEKWN 332 Drosophila willistoni
WGS:AAPP:GF11767-PA 314 VYNAHdQkgKLVDIGELLIAHLKNKT 339 Drosophila ananassae
EDW47162            283 IYNSHdSkgNLVDVGELLVANMQNKT 308 Drosophila sechellia
WGS:AAPU:GI18829-PA 301 IYNSHkQngELQDVGDVLISHVLThi 326 Drosophila mojavensis
EDW01242            283 FYSAHnSngEHVDEAEVIINHVFkdk 308 Drosophila grimshawi
EFZ11711            336 YYNDYdAngDKVNVAKIILERISKIK 361 red fire ant
EGI57896            337 YYDDFdAqgNKINVATILLERISKIT 362 Panamanian leafcutter ant
EFN63910            314 YYNDYdSkgTRVNVAKVILQRISEIT 339 Florida carpenter ant
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