5H3O


Conserved Protein Domain Family
CLZ
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pfam16526: CLZ (this model, PSSM-Id:374604 is obsolete and has been replaced by 465160)
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C-terminal leucine zipper domain of cyclic nucleotide-gated channels
The CLZ domain is the C-terminal leucine-zipper domain of of cyclic nucleotide-gated channel proteins. The CLZ domains form homotypic trimers in solution thus constraining the channel of the CNGs to contain three cyclic nucleotide-gated subunits, CNGA. The CLZ domains formed homotypic parallel 3-helix coiled-coil domains, consistent with their proposed role in regulating subunit assembly.
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Statistics
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PSSM-Id: 374604
Aligned: 55 rows
Threshold Bit Score: 51.0124
Created: 25-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5H3O_A       614 LLAKGREILKKDNLLDE----NAP-EEQKTVEEIAEHLNNAVKVLQTRMARLIVEHSSTEGKLMKRIEMLEK 680 Caenorhabditis elegans
XP_018650675 543 LMQRGQDILRKDNLLDEdilrKAQ-EQQESIEQCVQRIDNTMNQLTTRLARLIGEFGASQAKLKRRLTRLEQ 613 Schistosoma mansoni
GAA53384     489 LMKRGEEILRKDNLIDEevlrKAK-EQKESLDEYVRRLEGTVNNLSTRLARLIGEYGASQAKLKRRITQLEE 559 Clonorchis sinensis
EEB11744     433 LMERGCQLLRKDGLLDEnafkKSQ-VEHETLKDKVDRLESSIENLEDKLTQLIGDVTVFHNRMKRRASKIEQ 503 human body louse
EDW48107     545 LTQRGCQLLRKDGLLDEqifaDSQ-RVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKIKQRLAKLEM 615 Drosophila sechellia
XP_017945387 485 LEQKGREILLKMNKLDEqladELA-AKEQELEMKVGRLESNLDSLQTKLARLLAELESSAVKMTQRIRQLEW 555 tropical clawed frog
XP_006010051 513 LEEKGKAILLKMKMLDEaaalEVG-NQEAGLEAKVQRIEKSLGSLYTSLARLVGELQSSTLKLRYRIKLLEE 583 coelacanth
XP_319802    540 LTERGCQLLRKDGLLDEavfaNAQ-QTQDSLESGVARLEQTVENLNLRLARLLAEYSASQAKLKQRISKLED 610 Anopheles gambiae str. ...
XP_010704542 398 LEAKGREILLRMDKLDVhaeaAAA-AAREEAERRAQVLEAALEALQTRTARLLAQLESSALKLALRIGRLES 468 turkey
XP_016854267 456 LEAKGREILLQMGQLDTqv-eAREeAQRREEQRRTQALQLRLDALQTRLARMLAGLESGALKLtlrlerleg 526 green anole
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