3TEQ,3TER


Conserved Protein Domain Family
SOAR
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pfam16533: SOAR (this model, PSSM-Id:374610 is obsolete and has been replaced by 465164)
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STIM1 Orai1-activating region
SOAR is the Orai1-activating region of STIM1, where STIM1 are calcium sensors in the endoplasmic reticulum. As the store of calcium is depleted the calcium sensor in the ER activates Orai1, a Ca2+-release-activated Ca2+ (CRAC) channel, in the plasma membrane. The SOAR region, which runs from residues 340-443 on UniProtKB:Q13586, forms a dimer, and is essential for oligomerization of the whole of STIM1.
Links
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Statistics
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PSSM-Id: 374610
Aligned: 28 rows
Threshold Bit Score: 112.683
Created: 25-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3TEQ_A         1 PEALQKWLQLTHEVEVQYYNIKKQNAEKQLMVAKE---------GAEKIKKKRNTLFGTFHVA--HSSSLDDVDHKILTA 69  human
CDS35874     366 itELALLLQMTHELELRHYWEKRSAAAKQLMAAKE---------ACDRVRRKRSSLVGSVRLI--HSDNLDDVDSKLNAA 434 Echinococcus mu...
EDO49682     283 PEELAQWLHITYTKESRHFQMKRTQALKQMTEAKD---------ACDRIRKKRNSFIGSFRMA--HDLTIDEVDQQILAA 351 starlet sea ane...
XP_004365004 407 SDELRILLQRTFAIEMQQHTIRRQSAELELKAAHE---------ALENVTRKNKNFMGSFRVA--HGGSLDSLNDAVHSA 475 Capsaspora owcz...
EGD73265     280 rTKLKDLLQQSYEQETQLLTLVKELTQQRKQQARR---------EAEKLDAQRRSVFGVLRLA--NSVRPSQCETEMHSV 348 Salpingoeca ros...
CBY11086     282 TSDVKELLHRTYKAEKHNLDYRKRDARKKEHVATE---------NMKKLERANTSFFSSVRLL--HSHQLDHLDAALMQA 350 Oikopleura dioica
XP_003387480 363 rLALKQLLIETCLQEKYYLDANKRTAENEVMRAQK---------MCDKIKRKRASVIGAFRLA--NSSTLEDAGLMITKA 431 Amphimedon quee...
EFV61654     273 lpMLRQLLIKTFELEFSRLNQEKIDNLKEMQEAREwlelcllsiKVEKLRKKHSSLLSQIRSV--HGSESEQIDRRLLNL 350 Trichinella spi...
EJW81892      74 PLALQPLLRRTCELEVSYVGQQRMECIAEMREAIE---------HIDKLRKKQSSLVSSIKLAtgASSGTDHIDSRIFAL 144 Wuchereria banc...
EGT47872     287 PLALQPLLRRTCESEMAFLEKQRQDCFKEMKEAIE---------MVDKLQKKQGSVLSSLKLAtgASSTSDQVDSKIFAL 357 Caenorhabditis ...

3TEQ_A        70 KQALSEATAALRERLHRWQQIEILTGFQI 98  human
CDS35874     435 RRVLENVTADMQERKHRWSRIEDLTGLil 463 Echinococcus multilocularis
EDO49682     352 RAALADVTNEMEERQRRWYQIEALSGLPI 380 starlet sea anemone
XP_004365004 476 LQTLSHMRKESEEMSLRWQQIEDVLSVTv 504 Capsaspora owczarzaki ATCC 30864
EGD73265     349 LELYELLGQVAKERSERWTRLQKAVGFRl 377 Salpingoeca rosetta
CBY11086     351 HNAIEDIVRSQKESHDRWRKLEKIFSIAI 379 Oikopleura dioica
XP_003387480 432 VNKMQMVTEHFESFQKRWQSIEQIFGFPI 460 Amphimedon queenslandica
EFV61654     351 KQKMERTACSLEEQQQRWSRIELLCGFSI 379 Trichinella spiralis
EJW81892     145 KARMEKISLAMSECHQRWTEIESLCGFPL 173 Wuchereria bancrofti
EGT47872     358 KTRMEKIHTLTRETQERWMQIESLCGFPL 386 Caenorhabditis brenneri
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