6O1E


Conserved Protein Domain Family
Morc6_S5
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pfam17942: Morc6_S5 (this model, PSSM-Id:375439 is obsolete and has been replaced by 465579)
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Morc6 ribosomal protein S5 domain 2-like
This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.
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Statistics
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PSSM-Id: 375439
Aligned: 62 rows
Threshold Bit Score: 196.209
Created: 23-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6O1E_A        249 YSLRAYCSILYLKPRMQIILRGQKVKTQLVSKSLAYIERDVYRPKFL--SKTVRITFGF--NCRNKDHYGIMMYHRNRLI 324  human
OAE32475      188 FSLRAYVSILYKVPRMQIFIRDKKVKTKRIAGLLSQKETESYKPYGV--AESIKIELGFntENKN--LYGMMLYHRNRLI 263  Marchantia po...
EIE21004       67 YSLRQYVSVLYKVPRMQIFVRDQKVRTQRVTSLLRGKMHERFQLRNQt-LAYADIEMGFntEDPS--LYGMMIYHRNRLI 143  Coccomyxa sub...
EEN67772      235 YSLRAYCSILYLNPKMQIMLRGQKVKTFKIAKSLNNTEKDVYKPQWL--PRPVKITFGF---SPQKHHYGIMMYHRNRLI 309  Florida lancelet
KFO19245      210 YSLRAFCSILYMKPRMKIFLRQKKVTTQMIAKTLSNVGYDIYKPTFT--NKQVRITFGF--SSKKSNHFGIMMYHNNRLI 285  Damara mole-rat
KYO38121      205 YSLRAYCSILYLKPRMQIVLRQKKVKTQLMAKSLAHIEYNVYKPTFV--NKRVKITFGF--NCKNKSHCGIMMYHNNRLI 280  American alli...
XP_005460071  256 YSLRAFSSILYLKPRMLIIVRGQKVKSQLIAKSLAWIRKDHYKPAFLipPRRIPITFGY--NTKSKDQCGIMMYHKNRLI 333  Nile tilapia
XP_023806941  114 YSLRAYCSILYLKPRMQVVLRSKTVKTVLIAKSLACMRKDFYKPIFL--NKRVPIHFGF--NTKSKDQYGVMMYHKNRLI 189  Japanese medaka
CAG05872      174 HSLRAYCSILYLKPRMQIIVRGQKVKTQLMAKSLALVQKDHYKPNFL--PKRVPITFGY--NTKSKEQYGVMMYHKNRLI 249  spotted green...
XP_012953080  242 YSLRAYCSVLYLKPCVQIVLRQKKVNTQLITKSLANTEHDLYKPRFS--SERVKITFGF--NCKNKNHYGIMMYHKNRLI 317  mallard

6O1E_A        325 KAYEKVGCQlrA--NNM-GVGVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGEKLNDYW 382  human
OAE32475      264 KAYMRVGMQ--LeeNER-GMGVIGLAEADFLQPTHNKQDFDDTTAYRRLLKKLSDVLAEYW 321  Marchantia polymorpha subsp. rud...
EIE21004      144 RPYHRVGMQ--LepNDK-GVGVLGVVQADYLEPTHNKQDFNDTKEYRTLQKKLAEILQMYW 201  Coccomyxa subellipsoidea C-169
EEN67772      310 KGYERVGPQ--LkaGRQ-GLGVIGVIQCDFLQPTHNKQDFDYTKEYRSTIAALGQKLTDYW 367  Florida lancelet
KFO19245      286 KSFEKVGCQ--VkpTHGeGVGVIGVIECSFLKPTYNKQDFEYTKEYRLTINALAQKLNAYW 344  Damara mole-rat
KYO38121      281 KSYEKVGCQ--M--KGD-GVGVIGVIECNFLKPAHNKQDFEENKEYRRTVTALGQKLNLYW 336  American alligator
XP_005460071  334 KAYERVGCQ--LkaNNN-GVGVIGVIECNFLDPTHNKQSFMENDRYRKTMTNLGIKLEEYW 391  Nile tilapia
XP_023806941  190 KAYERVGCQ--LkaNNM-GVGVIGIIECNFLDPTHNKQSFIESDKYRKTMNNLGIKLEEYW 247  Japanese medaka
CAG05872      250 KAYKRVGCQ--LkgNDK-GVGVIGVIECNFLDPTHNKQSFIETEKYSKTIASLGIKLEDYW 307  spotted green pufferfish
XP_012953080  318 RSYKKVGCQ--Kk---GeGVGVIGVIECNFLKPAYNKQDFEESKEYQRMIFVLGQKLNNYW 373  mallard
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