Conserved Protein Domain Family
MID_MedPIWI
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pfam18296: MID_MedPIWI (this model, PSSM-Id:375723 is obsolete and has been replaced by 465699)
MID domain of medPIWI
MID domain of the medPIWI PIWI/Argonaute module. medPIWI is the core globular domain of the Med13 protein. Med13 is one member of the CDK8 subcomplex of the Mediator transcriptional coactivator complex. The medPIWI module in Med13 is predicted to bind double-stranded nucleic acids, triggering the experimentally-observed conformational switch in the CDK8 subcomplex which regulates the Mediator complex.
Links
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Statistics
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PSSM-Id: 375723
Aligned: 116 rows
Threshold Bit Score: 61.8701
Created: 20-Apr-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
A2VCZ5       1342 RDVGYMVVCPDNEALLNGAKTFFRDLTAVYESCRLGQHRP-IAKSHADGIVTVSDAGskalTDQTLIDWLPK----TINS 1416 zebrafish
XP_007673198  883 KDVRAYCIFPLNEDLQRLAEGFIADLGTAYEGCKLGTHAHiRNVSEEN---ELDDYE------DGLAPVELT-----DDD 948  Baudoinia pan...
XP_016209225 1018 KNVLAFCVCPGNPDLTKQVSLFMDYLGATFESCKLGAH------VRAT---QIGNIA------DGVVPVSLS-----ADA 1077 Verruconis ga...
EKG11491     1107 KNIMAYCVYPSSDQLKKPVTSFIDSISMAYESCKFGSHV-----RGPD----IEQIA----TNGRVSAFVNSgegdHWRP 1173 Macrophomina ...
XP_007784605 1110 KNVEAYCVYPLSDDLHEPAENFLSTMSLVYESCRLGAH------IRANGPGQLSETVs---AENGLVAIELQ-----EEA 1175 Coniosporium ...
XP_003839788 1066 KNIVSFCIYPHSESLRPCLEGFLLNLQLAYDSCKLGSH------GRIE---TVVEFE------GGLVPCKLT-----NPT 1125 Leptosphaeria...
OAL52531     1062 KNVVAFCIYPHSESLRPCLENFLVNLQLAYDGCKLGSY------ARVE---TVREFE------GGLVPYKVT-----SPP 1121 Pyrenochaeta ...
OAK96789     1070 KNVVAFCVYPDSDPLRPILDRFLLNLQLAYDTCKLGSH------ARVE---TVQEFE------GGLVPVNLE-----SHI 1129 Stagonospora ...
KNG50791     1070 KNIVTFCVYPHSDAIRPCLENFLLNMQLAYDGCKLGSH------SRVE---TVVEFE------GGLVPVRAT-----SAI 1129 Stemphylium l...
XP_018030548 1046 KNVMALSIYPHSSALKPCVEGFLVNMQLAYDGCKLGNH------SRAD---ALTEYP------NGLVPCKIG-----AGA 1105 Paraphaeospha...

A2VCZ5       1417 SSSsealNKLKLYAHVCRhDLASCLASqsldgslltqrNPAsssqtssssspvttaqnvtpttnsnsntntnttptstst 1496 zebrafish
XP_007673198  949 TLV----GAIKAYAAVSV-NLGKFLAS----------------------------------------------------- 970  Baudoinia pan...
XP_016209225 1078 SEH----SIFQSVRETCI-EFGKTIANfdwsc--kinfSPP--------------------------------------- 1111 Verruconis ga...
EKG11491     1174 TAQ----NCLQAVRDTCS-SLGRHLSRidfk------------------------------------------------- 1199 Macrophomina ...
XP_007784605 1176 SFQ----SVMRAVNEVFE-TLGKAWSA-----------PDY--------------------------------------- 1200 Coniosporium ...
XP_003839788 1126 SER----DAFRAYKDTCV-QLGKLLAMq----------YPKi-------------------------------------- 1152 Leptosphaeria...
OAL52531     1122 TRR----DAIKALRETCI-QLGKLLAI------------QHak------------------------------------- 1147 Pyrenochaeta ...
OAK96789     1130 SSK----GAFKALRDTCV-QLGKLLAI------------QHaq------------------------------------- 1155 Stagonospora ...
KNG50791     1130 TPR----ETFKLLRETCV-QLGKLLAI------------QHski------------------------------------ 1156 Stemphylium l...
XP_018030548 1106 SLR----TTFKALRDTCV-QLSKVLAAkha-------------------------------------------------- 1130 Paraphaeospha...

A2VCZ5       1497 sssssscpqgvgnmpsskpntippfgaqglqssqqsggqsagtlgdatsatsqpqvpsepaestmerekvgvptdgdsHA 1576 zebrafish
XP_007673198  971 ------------------------------------------------------------------------------VA 972  Baudoinia pan...
XP_016209225 1112 ------------------------------------------------------------------------------IE 1113 Verruconis ga...
EKG11491     1200 --------------------------------------------------------------------------khakAE 1205 Macrophomina ...
XP_007784605 1201 ------------------------------------------------------------------------------DR 1202 Coniosporium ...
XP_003839788 1153 -----------------------------------------------------------------------------qEQ 1155 Leptosphaeria...
OAL52531     1148 ----------------------------------------------------------------------------irEQ 1151 Pyrenochaeta ...
OAK96789     1156 ----------------------------------------------------------------------------igEQ 1159 Stagonospora ...
KNG50791     1157 ----------------------------------------------------------------------------qeQQ 1160 Stemphylium l...
XP_018030548 1131 ---------------------------------------------------------------------------qmrDK 1135 Paraphaeospha...

A2VCZ5       1577 VT-YPPAIVIYIVNPFsyeENCQGS---SSSVWTiaLlRCYLEM-LQL-LPPH-IRNAVYVQIIPSQYLLQPvwseERHI 1649 zebrafish
XP_007673198  973 SLeTDRTIVVYLINPF---QHPRAAryiCACFWL--LcKAYRDN-VPKnQRSQ-QQSDVAFQLLPIELIACP----DGMV 1041 Baudoinia pan...
XP_016209225 1114 DLnKIDTLVIYMIDPFt--NSSRGLaelCSSFWT--LyETYRQA-VASpMRRT-VRPDIVLQVLPIRYVANP----HTPV 1183 Verruconis ga...
EKG11491     1206 DSsTVDALVVYLVNPF---SDPHNLwqlCSAFWA--LfQAYLPSvPSNrAVDD-SKPELVLQLVPVKYIASF----EAPV 1275 Macrophomina ...
XP_007784605 1203 GEaKIDAIVIYLINPF---KTSRAFwnlCSAFWT--LfNVYRQG-CQA-QPEVgPKPDLVLQVVPIKYIASF----QELI 1271 Coniosporium ...
XP_003839788 1156 QEaKIDAFVIYMVDPF---GGPSALwelCQSFWA--LfQAYGQG--PPgRPDQsQKPDLVLQVVPMKYIASF----DAPV 1224 Leptosphaeria...
OAL52531     1152 HDaKIDAFVIYMVDPF---GDASALwelCSAFWM--LfQTYGQG-PPG-RPDQpQKPDLVLQVVPMKYVASF----DVPV 1220 Pyrenochaeta ...
OAK96789     1160 QDtKVDAFVVYMVDPF---GSPAALwelCSAFWA--LfQAYGQGpLGR--PDAvQRPDVVLQIIPIKYLASF----DNPV 1228 Stagonospora ...
KNG50791     1161 DS-KIDAFVVYMIDPL---DGSSALwelCSAFWA--LfQAYTQG--HSgRPDQsQKPDVVLQIIPIKYIASF----DAPV 1228 Stemphylium l...
XP_018030548 1136 DDsRIDAFVIYMIDPF---EQAPAIwelCSAFWS--LfQSYQQPpSRT---EV-QKPDLVLQIVPIRYIASF----EAPV 1202 Paraphaeospha...

A2VCZ5       1650 YAQ--HLKSLAFSVYTQCRR 1667 zebrafish
XP_007673198 1042 MLDakQLANIAREVYDRCPP 1061 Baudoinia panamericana UAMH 10762
XP_016209225 1184 VMDslFYQKLAREIYDRCPP 1203 Verruconis gallopava
EKG11491     1276 VLEpsLLTRFAREIYDRCPP 1295 Macrophomina phaseolina MS6
XP_007784605 1272 VLDpnTYFRLAREVYDRCPP 1291 Coniosporium apollinis CBS 100218
XP_003839788 1225 ILDpsTYINLAREVYDRCPP 1244 Leptosphaeria maculans JN3
OAL52531     1221 ILDpsAYAKLAREVYDRCPP 1240 Pyrenochaeta sp. DS3sAY3a
OAK96789     1229 ILEasTYVNLAREVYDRCPP 1248 Stagonospora sp. SRC1lsM3a
KNG50791     1229 ILDpsTYFSLAREVYDRCPP 1248 Stemphylium lycopersici
XP_018030548 1203 ILDsnIYTALAREVYDRCPP 1222 Paraphaeosphaeria sporulosa
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