pfam18385: Tiam_CC_Ex (this model, PSSM-Id:375811 is obsolete and has been replaced by 408184)
T-lymphoma invasion and metastasis CC-Ex domain
This is the CC and Ex subdomains found in PH-CC-Ex globular domain from Tiam1 and Tiam2 proteins (T-lymphoma invasion and metastasis). The CC subdomain forms an antiparallel coiled coil with two long alpha-helices, together with the C-terminal Ex subdomain they form a small globular domain comprising three alpha-helices. The CC subdomain of the Tiam2 PHCCEx domain follows the C-terminal alpha1 helix of the PH pfam00169 subdomain through a four-residue linker.
Jiyao W et al.(2023). "The conserved domain database in 2023.",