pfam18455: GBR2_CC (this model, PSSM-Id:375881 is obsolete and has been replaced by 465774)
Gamma-aminobutyric acid type B receptor subunit 2 coiled-coil domain
This is the intracellular coiled-coil domain found in Gamma-aminobutyric acid type B receptor subunit 2 (GBR2). The coiled-coil complex between the GABAB receptor subunits GBR1 and GBR2 is responsible for facilitating the surface transport of the intact receptor. Disruption of the hydrophobic coiled-coil interface with single mutations in either subunit impairs surface expression of GBR1, confirming that the coiled-coil interaction is required to inactivate the adjacent ER retention signal of GBR1.
Jiyao W et al.(2023). "The conserved domain database in 2023.",