2CSV


Conserved Protein Domain Family
Bbox2_TRIM16-like

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cd19769: Bbox2_TRIM16-like 
B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM16, TRIM29, TRIM47 and similar proteins
This family includes a group of tripartite motif-containing proteins, such as TRIM16, TRIM29 and TRIM47. TRIM16, also termed estrogen-responsive B box protein (EBBP), is a regulator that may play a role in the regulation of keratinocyte differentiation. It may also act as a tumor suppressor through affecting cell proliferation and migration or tumorigenicity in carcinogenesis. TRIM29, also termed ataxia telangiectasia group D-associated protein (ATDC), plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. TRIM47, also known as gene overexpressed in astrocytoma protein (GOA) or RING finger protein 100 (RNF100), plays an important role in the process of dedifferentiation that is associated with astrocytoma tumorigenesis. TRIM16 and TRIM29 belong to an unclassified TRIM (tripartite motif) family of proteins that do not have RING fingers and thus lack the characteristic tripartite (RING (R), B-box, and coiled coil (CC)) RBCC motif. TRIM47 belongs to the C-IV subclass of TRIM family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a RING finger, Bbox1 and Bbox2, and two coiled coil domains, as well as a B30.2/SPRY (SplA and ryanodine receptor) domain positioned C-terminal to the RBCC domain. The type 2 B-box (Bbox2) zinc finger is characterized by a CHC3H2 zinc-binding consensus motif.
Statistics
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PSSM-Id: 380827
Aligned: 33 rows
Threshold Bit Score: 45.7797
Created: 22-Oct-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C H C [ED] C C H HClick to see conserved feature residue pattern help
Evidence:
  • Structure:2CSV; Homo sapiens TRIM29 binds two Zn2+ ions through its B-box motif.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #  #       #  #    #  #     #  #              
2CSV_A         19 RKCPVHGKTMELFCqTDQTCICYLCMFq-EHKNHSTVTV-EEAKAEKE 64   human
XP_007887111  150 RRCPAHGKLLDLFCrTDQIFICSFCTTe-RHRNHQTVTV-EEEVSKQK 195  elephant shark
KTG33240       68 NICPDHGKMLLVYCrTDQLCICHLCITd-KHRGHDVIPV-EEEVANKQ 113  common carp
XP_022057936  139 RVCSKHNKLKDFFCrEDQMCICAVCMKd-EHATHETVAT-QDESVARR 184  spiny chromis
PWA32933      200 PLCEIHNRGISLYCkSDQMCICPECEIe-DHNDHDTITV-EAEWMKTK 245  western mosquitofish
XP_020370044  139 RRCAAHGKLLEFFCrSDGACICGLCIVq-QHREHTVTGA-EEEASRLK 184  whale shark
NP_001070087  168 KMCKTHKRLLDAYCrNEHACVCKECAEs-SHKGHDVVST-EREWKKKT 213  zebrafish
NP_001018156   86 QPCPVHGEKIELFCqNDEQLLCARCRKc-GHGWHKTMPL-QQAVRQRR 131  zebrafish
EFX82282      117 GKCPIHNTSIDFWCyNDEVLLCGGCRIs-CHLGHDVVRLlDRNKEELE 163  common water flea
ETE58773      685 FVCPKHKVILDLFCqEDEKLICAICHKssEHKTHTEKQL-QNRMKMVE 731  king cobra

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