2A2U,1ZNL,1I04,3KFF,1GM6,1EW3,2L9C


Conserved Protein Domain Family
lipocalin_MUP-like

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cd19428: lipocalin_MUP-like 
major urinary proteins (MUPs) and similar proteins
Mouse urine contains major urinary proteins (MUPs) which bind low molecular weight hydrophobic organic compounds such as urinary volatile pheromones such as the male-specific 2-sec-butyl-4,5-dihydrothiazole (SB2HT) which hastens puberty in female mice. The association between MUPs and these volatiles slows the release of the volatiles into the air from urine marks. MUPs may also act as pheromones themselves. MUPs, expressed in the nasal and vomeronasal mucosa, may be important for delivering urinary volatiles to receptors in the vomeronasal organ. This group includes MUPs encoded by central genes in the MUP cluster, as well as those encoded by peripheral genes such as Darcin/Mup20 which binds most of the male pheromone SB2HT in urine and was the first MUP shown to have male pheromonal activity in its own right. This group includes rat MUPs (also called alpha-2U globulins) and other lipocalins such as major horse allergen Equ c 1 and boar salivary lipocalin, a pheromone-binding protein specifically expressed in the submaxillary glands of the boar. It belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.
Statistics
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PSSM-Id: 381203
View PSSM: cd19428
Aligned: 9 rows
Threshold Bit Score: 258.526
Threshold Setting Gi: 119570938
Created: 6-Feb-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand binding
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding cavity [chemical binding site]
Evidence:
  • Comment:hydrophobic cavity binds different hydrophobic ligands; ligands are bound within the beta-barrel in a central internal water-filled cavity lined with polar and hydrophobic amino acids
  • Comment:based on mouse MUP2 and on other lipocalin/cytosolic fatty-acid binding protein family members with structure
  • Structure:1ZNL; mouse MUP2 bound with decan-1-ol, contacts 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #   #    #             # # ## #       # # #          # # #        # # 
2A2U_A     24 STRGNLDVAKLNGDWFSIVVASNKREKIEENGSMRVFMQHIDVLEn-SLGFKFRIKenGECRELYLVAYKTPEdGEYFVE 102 Norway rat
1ZNL_A     17 STGRNFNVEKINGEWHTIILASDKREKIEDNGNFRLFLEQIHVLEk-SLVLKFHTVrdEECSELSMVADKTEKaGEYSVT 95  house mouse
1I04_A     23 STGRNFNVEKINGEWHTIILASDKREKIEDNGNFRLFLEQIHVLEn-SLVLKFHTVrdEECSELSMVADKTEKaGEYSVT 101 house mouse
3KFF_A      5 SKGQNLNVEKINGEWFSILLASDKREKIEEHGSMRVFVEHIHVLEn-SLAFKFHTVidGECSEIFLVADKTEKaGEYSVM 83  house mouse
1GM6_A      8 VVTSNFDASKIAGEWYSILLASDAKENIEENGSMRVFVEHIRVLDnsSLAFKFQRKvnGECTDFYAVCDKVGD-GVYTVA 86  pig
1EW3_A      1 VAIRNFDISKISGEWYSIFLASDVKEKIEENGSMRVFVDVIRALDnsSLYAEYQTKvnGECTEFPMVFDKTEEdGVYSLN 80  horse
2L9C_A     19 SMERNFNVEKINGEWYTIMLATDKREKIEEHGSMRVFVEYIHVLEn-SLALKFHIIinEECSEIFLVADKTEKaGEYSVT 97  house mouse
JAA45581   20 VVECNFDLSQVSGEWYTILWGSEDREMIEENGSMRLFLEYVEDLDnsSVLFKYHKNvnGECAELNLITDPTEEnGVYSVP 99  common vampire bat
EAW50553   23 AVTSNFDLSKISGEWYSVLLASDCREKIEEDGSMRVFVKHIDYLG--NSSLTFKLN--GNCTEINLACKPTEKnAICSTD 98  human
Feature 1         # # #        # # #          # # #                                          
2A2U_A    103 YDGGNTFTILKTDYDRYVMFHLINFknGETFQLMVLYGRTKDLSSDIKEKFAKLCEAHGITRDNIIDLTKTDRCLQARG 181 Norway rat
1ZNL_A     96 YDGFNTFTIPKTDYDNFLMAHLINEkdGETFQLMGLYGREPDLSSDIKERFAQLCEEHGILRENIIDLSNANRCLQARE 174 house mouse
1I04_A    102 YDGFNTFTIPKTDYDNFLMAHLINEkdGETFQLMGLYGREPDLSSDIKERFAQLCEEHGILRENIIDLSNANRCLQARE 180 house mouse
3KFF_A     84 YDGFNTFTILKTDYDNYIMFHLINEkdGKTFQLMELYGRKADLNSDIKEKFVKLCEEHGIIKENIIDLTKTNRCLKARE 162 house mouse
1GM6_A     87 YYGENKFRLLEVNYSDYVILHLVDVngDKTFQLMEFYGRKPDVEPKLKDKFVEICQQYGIIKENIIDLTKIDRCFQLRG 165 pig
1EW3_A     81 YDGYNVFRISEFENDEHIILYLVNFdkDRPFQLFEFYAREPDVSPEIKEEFVKIVQKRGIVKENIIDLTKIDRCFQLRG 159 horse
2L9C_A     98 YDGSNTFTILKTDYDNYIMIHLINKkdGETFQLMELYGREPDLSSDIKEKFAQLSEEHGIVRENIIDLTNANRCLEARE 176 house mouse
JAA45581  100 YDGYNTFYIIEAVYNDYVIFHNMNFgnGRKTDVIEMNARKPDVRPELKERFEEICRNRGIPTEHILDVSKTDRCLQARW 178 common vampire bat
EAW50553   99 YNGLNVIDILETDYDNYIYFYNKNIknGETFLMLELYVRTPDVSSQLKERFVKYCEEHGIDKENIFDLTKVDRCLQARD 177 human

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