2R73,2RA6


Conserved Protein Domain Family
lipocalin_trichosorin-like

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cd19430: lipocalin_trichosorin-like 
trichosurin and similar proteins
Trichosurin is a protein from the milk whey of the common brushtail possum, Trichosurus Vulpecula, and shows a preference for binding small phenolic ligands. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.
Statistics
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PSSM-Id: 381205
Aligned: 3 rows
Threshold Bit Score: 235.725
Created: 7-Jan-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand binding
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding cavity [chemical binding site]
Evidence:
  • Comment:hydrophobic cavity binds different hydrophobic ligands; ligands are bound within the beta-barrel in a central internal water-filled cavity lined with polar and hydrophobic amino acids
  • Comment:based on trichosurin and on other lipocalin/cytosolic fatty-acid binding protein family members with structure
  • Structure:2RA6; Trichosurus vulpecula trichosurin bound with 4-ethylphenol, contacts 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  #   #                  # #  # #      # # #          # # #        # #  
2R73_A        14 SDEKERKWEQLSRHWHTVVLASSDRSLIEEEGPFRNFIQNITVESGNLNGFFLTRKNGQCIPLYLTAFKTEEArQFKLNY 93  silver-gray bru...
2RA6_A        14 SDEKERKWEQLSRHWHTVVLASSDRSLIEEEGPFRNFIQNITVESGNLNGFFLTRKNGQCIPLYLTAFKTEEArQFKLNY 93  silver-gray bru...
XP_012396091  26 DLSDEKEQKWLSGHWHLVELASSDTSLIGVEGPFRNFIQNITVENGNLNGLFLTRKNGRCIQLSLIALKTKEAcHFKLNY 105 Tasmanian devil
Feature 1           # # #        # # #          # # #                                     
2R73_A        94 YGTNDVYYESSKPNEYAKFIFYNYHDGKVNVVANLFGRTPNLSNEIKKRFEEDFMNRGFRRENILDISEVDHC 166 silver-gray brushtail ...
2RA6_A        94 YGTNDVYYESSKPNEYAKFIFYNYHDGKVNVVANLFGRTPNLSNEIKKRFEEDFMNRGFRRENILDISEVDHC 166 silver-gray brushtail ...
XP_012396091 106 HGINDIYYESSKTNEYARFILYNHHNGKVNVVANLFGRTPNLSDEIKKKFEEDFLSRGYRKENILDVSELDHC 178 Tasmanian devil

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