3BUR,3CMF,3UZW


Conserved Protein Domain Family
AKR_AKR1D1-3
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cd19109: AKR_AKR1D1-3 
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AKR1D family of aldo-keto reductase (AKR)
The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.
Links
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Statistics
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PSSM-Id: 381335
Aligned: 12 rows
Threshold Bit Score: 597.551
Created: 9-Apr-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic
Conserved site includes 32 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:3BUR: Homo sapiens delta(4)-3-ketosteroid 5-beta-reductase (AKR1D1) in complex with cofactor NADP and testosterone, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 ###                          #    #                            # #     
3BUR_A        15 GNSIPIIGLGTYSEpkstPKGACATSVKVAIDTGYRHIDGAYIYqNEHEVGEAIREKIAEGkvRREDIFYCGKLWAtnHV 94  human
3CMF_A        35 GNSIPIIGLGTYSEpkstPKGACATSVKVAIDTGYRHIDGAYIYqNEHEVGEAIREKIAEGkvRREDIFYCGKLWAtnHV 114 human
3UZW_A        35 GNSIPIIGLGTYSEpkstPKGACATSVKVAIDTGYRHIDGAYIYqNEHEVGEAIREKIAEGkvRREDIFYCGKLWAtnHV 114 human
NP_001025609  15 GNSIPVLGLGTYSSprttPKGTCLEAVKLAIDLGYRHIDGAYVYyNEHEVGQAIREKIAEGkvKREDIFYCGKLWNtcHP 94  western clawed ...
NP_001264322  15 GNSIPLLGLGTYADpqktPKGTCLESVKIAIDTGYRHIDGAFVYyNEHEVGQAIREKIAEGkiKREDIFYCGKLWNtcHP 94  chicken
XP_006008266  15 GNSIPVIGLGTYASlkttPEGACAEAVKVAIDAGYRHIDGAFIYfNEHEVGQAIQEKIAEGkmKREDIFYCGKLWCtcHP 94  coelacanth
XP_007883703  15 GNTIPIIGLGTYSSnrttTALECYEAVKQAIDIGYRHIDGAWIYgNEAEVGRAVREKIADGivERKDIFYCGKLWNtcHP 94  elephant shark
P51857        15 GNSIPIIGLGTYSEpkstPKGACATSVKVAIDTGYRHIDGAYIYqNEHEVGEAIREKIAEGkvRREDIFYCGKLWAtnHV 94  human
ACQ58910      17 GNSIPLIGLGTYGDprttPKGTAYESVKVAIETGYRHLDGALVYfNEHEVGQAIRDTISDGtvKREDIFYCGKLWNtfHS 96  sablefish
P31210        15 GNSIPIIGLGTYSDpr-pVPGKTFIAVKTAIDEGYRHIDGAYVYrNEHEVGEAIREKVAEGkvKREEIFYCGKLWStdHD 93  Norway rat
BAA82867      15 GNSIPIIGLGTYSEpkttPKGSCATSVKIAIDTGYRHIDGAYIYqNEHEVGETFREKIAEGkvRREDIFYCGKLWAtnHD 94 
OCT58169      45 PTANPEICAGTKQEteqsFIDNVKEATKLALDLGYRHVDGAFFYsSETGVGQAFHEKFADGtlKREDLFYTSKLWNtfHQ 124 African clawed ...

Feature 1                                 #           #                                    ##    
3BUR_A        95 PEMVRPTLERTLRVLQLDYVDLYIIEVPMafkPGDEIYPRDENGKWLYhKSNLCATWEAMEACKDAGLVKSLGVSNFNRR 174 human
3CMF_A       115 PEMVRPTLERTLRVLQLDYVDLYIIEVPMafkPGDEIYPRDENGKWLYhKSNLCATWEAMEACKDAGLVKSLGVSNFNRR 194 human
3UZW_A       115 PEMVRPTLERTLRVLQLDYVDLYIIHVPMafkPGDEIYPRDENGKWLYhKSNLCATWEAMEACKDAGLVKSLGVSNFNRR 194 human
NP_001025609  95 PELVRPTLEKTLKTLQLDYVDLYIIELPMafkPGDEIYPRDANGKYLYhKTDLCATWEALEECKDAGLVKSIGVSNFNRR 174 western clawed ...
NP_001264322  95 PELVRPTLEKTLKILQLDYVDLYIIELPMafkPGEAIYPRDENGKIIYhETNLCATWEAMEACKDAGLAKSIGVSNFNRR 174 chicken
XP_006008266  95 PELVRPTLERTLKLLQMDYVDLYIIELPMafqPGESIYPLDENGKLLYyKTDLCATWEALEACKDAGLVKSIGVSNFNRR 174 coelacanth
XP_007883703  95 PELVRPTLERSLAKLKFDYIDLYLIELPMafqPGDDNYPKDENGAIRYyRTELCATWEAMEACKDAGLVKSIGVSNFNRR 174 elephant shark
P51857        95 PEMVRPTLERTLRVLQLDYVDLYIIEVPMafkPGDEIYPRDENGKWLYhKSNLCATWEAMEACKDAGLVKSLGVSNFNRR 174 human
ACQ58910      97 PELVRPALEKTLKALQLDYVDLYIVEMPTafkPGDTFYPRDENGKYIYhETDLCATWEALEICKDAGLIKSLGVSNFNRR 176 sablefish
P31210        94 PEMVRPALERTLQTLKLDYIDLYIIEMPMafkPGEEFYPKDENGRVIYhKSNLCATWEALEACKDAGLVKSLGVSNFNRR 173 Norway rat
BAA82867      95 PVMVRPTLERTLKVLKLDYIDLYIIEIPMafkPGDVVYPRDENGKWLYhKTNLCATWEALEACKDAGLVKSLGVSNFNRQ 174
OCT58169     125 PHLVRPALEKTLSFLKMDYIDLYLIHMPMsfkPAAVLFPKNEDGTCAFdQPDLLQTWQELEKCKDAGLVKSIGVSNFNRR 204 African clawed ...

Feature 1                          #                          #######    #        #              
3BUR_A       175 QLELILNKPGLKhKPVSNQVECHPYfTQPKLLKFCQQHd-IVITAYSPLGTSRNpiWVNVSSPPLLKDALLNSLGKRYNK 253 human
3CMF_A       195 QLELILNKPGLKhKPVSNQVECHPYfTQPKLLKFCQQHd-IVITAYSPLGTSRNpiWVNVSSPPLLKDALLNSLGKRYNK 273 human
3UZW_A       195 QLELILNKPGLKhKPVSNQVECHPYfTQPKLLKFCQQHd-IVITAYSPLGTSRNpiWVNVSSPPLLKDALLNSLGKRYNK 273 human
NP_001025609 175 QLELILNKPGLKyKPATNQVECHPYfTQPKLLEFSGQHd-IVTVGYSPIGTCRDetWVNVSSPPLLKDPLLNAIGKKYNK 253 western clawed ...
NP_001264322 175 QLEMILNKPGLKhKPVSNQVECHPYfTQPKLLEFCRQHd-IVIVGYSPLGTSRDetWVNVSSPPLLEDPVLNAIGKKYNK 253 chicken
XP_006008266 175 QLELILNKPGLKyKPVCNQVECHPYlNQSKLLNYCREKe-IIIVGYSPLGTCRDgsWVNVKLPPLLEDKLLNSIGKKYNK 253 coelacanth
XP_007883703 175 QLEAILNKPGLKhKPVANQVECHPYfTQIKLKTFCESHd-IVLVGYSPLGTCRDklWVNMNLPPLLEDELLVSVGKRWNK 253 elephant shark
P51857       175 QLELILNKPGLKhKPVSNQVECHPYfTQPKLLKFCQQHd-IVITAYSPLGTSRNpiWVNVSSPPLLKDALLNSLGKRYNK 253 human
ACQ58910     177 QLELILNKPGLKhRPVSNQVECHPYfTQPKLLEYCQQKd-IVVVGYSPLGTSRDasWVNLKCPPLLEDELLASIAKKYNK 255 sablefish
P31210       174 QLEVILNKPGLKyKPVTNQVECHPYfTQTKLLEVSASSmtSFIVAYSPLGTCRNplWVNVSSPPLLKDELLTSLGKKYNK 253 Norway rat
BAA82867     175 QLELLLNKPGLKhKPVCNQVECHPYfTQPKLLKFCQQHd-IIIVAYSPLGTCRNpmWVNTSLPPLLKDTLLNSLGKKYKK 253
OCT58169     205 QLEMILNKPGLKyKPVCNQIECHPYlNQKQMLEFCKSKd-IVVVAYGVLGSPGAgkWVDQSCPVLLEDPVLVSIGKKYQK 283 African clawed ...

Feature 1          #              ######  #  ##                              #        
3BUR_A       254 TAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFVELLMWRDHPEYPF 322 human
3CMF_A       274 TAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFVELLMWRDHPEYPF 342 human
3UZW_A       274 TAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFVELLMWRDHPEYPF 342 human
NP_001025609 254 TAAQVALRFNAQRGVAVIPKSFNPDRIKENFQIFDFSLTDKEMKDIEALNKNVRYVELLMWSDHPEYPF 322 western clawed frog
NP_001264322 254 TAAQVALRFSIQRGVVVIPKSFNPQRIRENFQIFDFSLTEKEMKEIEALNKNVRYVELLMWRDHPEYPF 322 chicken
XP_006008266 254 TAAQISLRYNIQRGVVVIPKSFNPQRIKENAEIFDFCLTDEEMKAIDSLHKNERYVELLMWNDHPEYPF 322 coelacanth
XP_007883703 254 SSAQVALHYQLQRNVVIIPKSFNPQHIQSNFQIFDFSLTDEEMKAIDELNKNVRYVELLMWSDHPEYPF 322 elephant shark
P51857       254 TAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFVELLMWRDHPEYPF 322 human
ACQ58910     256 NTAQVALRFNVQRGVVVIPKSFNPARISENFQIFDFSLSEAEMKAIEGLNKNIRFVELLMWSDHPEYPF 324 sablefish
P31210       254 TQAQIVLRFDIQRGLVVIPKSTTPERIKENFQIFDFSLTKEEMKDIEALNKNVRFVEMLMWSDHPEYPF 322 Norway rat
BAA82867     254 TAAQIVLRFNVQRGVVVIPKSFNPERIKENFQIFDFSLTEEEMKDIEALNKNVRYVELLMWRDHPEYPF 322
OCT58169     284 SPAQVSMRYMIQRGCVAIAKSFNPHRMKQNIEVFDFQLSKEEMEAIDGLNKKMRYWKFSDWEKHPQYPF 352 African clawed frog

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