3EAU,1ZSX


Conserved Protein Domain Family
Aldo_ket_red_shaker
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cd19141: Aldo_ket_red_shaker 
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Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Links
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Statistics
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PSSM-Id: 381367
Aligned: 11 rows
Threshold Bit Score: 605.981
Created: 13-Mar-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic
Conserved site includes 35 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:3EAU: Rattus norvegicus voltage-dependent K+ channel beta subunit in complex with cortisone and cofactor NADPH, contacts at 4A.
    - View structure with Cn3D
  • Structure:1ZSX: Homo sapiens potassium channel Kv beta-subunit (KCNAB2) in complex with cofactor NADP; contacts at 4A.
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                         ###     #                     #   ##                           
3EAU_A         4 FYRNLGKSGLRVSCLGLGTWVTFGGQitDEMAEHLMTLAYDNGINLFDTAEVYaa----------------------gkA 61  Norway rat
1ZSX_A        25 FYRNLGKSGLRVSCLGLGTWVTFGGQitDEMAEQLMTLAYDNGINLFDTAEVYaa----------------------gkA 82  human
Q14722        90 PHRNLGKSGLRVSCLGLGTWVTFGGQisDEVAERLMTIAYESGVNLFDTAEVYaa----------------------gkA 147 human
O43448        79 KYRNLGKSGLRVSCLGLGTWVTFGSQisDETAEDVLTVAYEHGVNLFDTAEVYaa----------------------gkA 136 human
XP_002130946   2 LYRNLGTSGLRVSVIGFGTWATFGNQisDDLAEELLTIAYENGVNFFDTAEVYaa----------------------gkA 59  Ciona intestinalis
EEN70106      18 RYRNLGRSGLRVSCLGLGTWVTFGGQvtDEMAEELMTLAYENGVNLFDTAEVYaa----------------------gkA 75  Florida lancelet
XP_006811114   2 LYRNLGKSGLKVSCLGLGTWVTFGGQitDEMAEELVTLAFETGINLFDTAEVYag----------------------gkA 59  Saccoglossus ko...
OWF37716      35 NYRNLGKSGLRVSCVGLGTWVTFGGQvtDEVAEEILTLAYESGINYFDTAEVYaagnhkkdnpdlpisayqqmqvacegA 114 Yesso scallop
XP_023228406  60 RYKNLGKSGLKVSVIALGTWVNFGSQlsEEVAEEIVTAAYESGINFFDTGDIYag----------------------gkA 117 bark scorpion
EDV24247       1 YFRNLGKSGLRVSALGFGTWVTFGSQvsDKHAEELITVAYENGINFFDTAEVYag----------------------gkA 58  Trichoplax adha...
ESN91839       8 PIRNLGKSGLRISNIVLGTFATFGSQisDEVTEDIVTLAYEHGVHAFDTSEAYag----------------------grA 65  Helobdella robusta

Feature 1                              #  #       #                            #                 
3EAU_A        62 EVVLGNIIKKKgWRRSSLVITTKIFWGGKAeTERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEeTVRAMTH 141 Norway rat
1ZSX_A        83 EVVLGNIIKKKgWRRSSLVITTKIFWGGKAeTERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEeTVRAMTH 162 human
Q14722       148 EVILGSIIKKKgWRRSSLVITTKLYWGGKAeTERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEeIVRAMTH 227 human
O43448       137 ERTLGNILKSKgWRRSSYVITTKIFWGGQAeTERGLSRKHIIEGLRGSLERLQLGYVDIVFANRSDPNCPMEeIVRAMTY 216 human
XP_002130946  60 EILLGNILKKKkWRRSSYIISTKLFWGGRAeTERGLSRKHIIEGINGSLQRLQMSYVDIVFANKSDPTTSMEeIVRAFTQ 139 Ciona intestinalis
EEN70106      76 EITLGNIIKKKgWRRSSLVITTKIFWGGRAeTERGLSRKHIIEGLQGSLQRLQLDYVDVVFANRPDPNTPMEeTVRAFSY 155 Florida lancelet
XP_006811114  60 EIVLGKILKKKnWRRSSIVVTTKIYWGGKAeTERGLSRKHIIEGLMASLQRLQLDYVDMVLANRPDPNTPMEeIVRAFTY 139 Saccoglossus ko...
OWF37716     115 EILLGKLLKKKtWRRSSYVISTKIYWGGKAeTEKGLSRKHILEGLRGSLDRLQLEYVDIVFANKPDPHTPMEeVVRAFTH 194 Yesso scallop
XP_023228406 118 EILLGKILKKKeWKRSSYIVATKLFWGGKSeTERGFSRKQILEGLEASLERLQLPYVDIVFVNKADPMCPMEeIVRACTH 197 bark scorpion
EDV24247      59 EIVLGQVLRKKqWRRSTLVISTKIFWGGRGeNEQGLSRKHIIEGLKASLHRLQLEYVDIVFANRPDSTTPMEeIVRAFTF 138 Trichoplax adha...
ESN91839      66 EIVLGKILKKKaWRRSSYIVITKVSWGGKAeTEKGLSRKHIIEGLRSSLDRLQLDYVDVILANKSDPRTPVEeIARAFTH 145 Helobdella robusta

Feature 1                    ##                        #                            #######  # # 
3EAU_A       142 VINQGMAMYWGTSRWSSMEIMEAYSVARqfnlipPICEQAEYHMFQREKvEVQLPELFHKIGvGAMTWSPLACGIVSGKY 221 Norway rat
1ZSX_A       163 VINQGMAMYWGTSRWSSMEIMEAYSVARqfnltpPICEQAEYHMFQREKvEVQLPELFHKIGvGAMTWSPLACGIVSGKY 242 human
Q14722       228 VINQGMAMYWGTSRWSAMEIMEAYSVARqfnmipPVCEQAEYHLFQREKvEVQLPELYHKIGvGAMTWSPLACGIISGKY 307 human
O43448       217 VINQGLALYWGTSRWGAAEIMEAYSMARqfnlipPVCEQAEHHLFQREKvEMQLPELYHKIGvGSVTWYPLACGLITSKY 296 human
XP_002130946 140 VISDGKAMYWGTSRWSSVEICEAFSVARqynlipPTVEQAEYHFFQREMvETQIPYLHQRLGiGSISWSPLSCGVISGKY 219 Ciona intestinalis
EEN70106     156 VIERGWALYWGTSRWSPMEIMEAYSVARqfnlipPIAEQAEYHLFQREKvEAQLPELYAKIGvGAMTWSPLACGIITGKY 235 Florida lancelet
XP_006811114 140 CINQGMAMYWGTSRWSTMEIMEAYSVARqfnlipPVLEQSEYHLFNREKvETQLPELFHKIGlGTITWSPLACGILTGKY 219 Saccoglossus ko...
OWF37716     195 VINQGWAMYWGSSRWSATEIMEAHSVARqfnlipPVAEQAEYHLFHREKvELHMPELYHKIGiGTVTWSPLAGGVLTGKY 274 Yesso scallop
XP_023228406 198 CINRGMALYWGTSRWSAMEIMESYTVARqfnlipPSVEQTEYHLFQREKvEIYLPELFHKIGtGSITWSPQAFGILTGKF 277 bark scorpion
EDV24247     139 VINQGLAFYWGVSQWTEADVMEAYAVARqynlipPTAIQAEYHFMCREQmEAVKKNLYDKCGvGAVTWSPLAGGVLSGKY 218 Trichoplax adha...
ESN91839     146 VINQGWAMYWGTSKWAATEIMEIYSVCRqfnlipPIVEQSEYNFFKRESiEMHLPELFHKIGlGLMAACPLMGGMMSGKY 225 Helobdella robusta

Feature 1               ###                                           #                #####   # 
3EAU_A       222 ds-giPPYSRASLkgyq----wlkdKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQL 296 Norway rat
1ZSX_A       243 ds-giPPYSRASLkgyq----wlkdKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNADQL 317 human
Q14722       308 gn-gvPESSRASLkcyq----wlkeRIVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQL 382 human
O43448       297 dg-rvPDTCRASIkgyq----wlkdKVQSEDGKKQQAKVMDLLPVAHQLGCTVAQLAIAWCLRSEGVSSVLLGVSSAEQL 371 human
XP_002130946 220 td-aiPCMSRAQLkgfs----wlkeKIISESGRRQQAKLMELQIIADRFGCSLSQLAIAWCLRFEANNGVLIGATSTEQL 294 Ciona intestinalis
EEN70106     236 dd-gvPIYSRAALkgyg----wlkdKILSEDGRRQQAKLREVQIIADKLNCTLPQLAIAWCLRNETISSVLLGASSIEQL 310 Florida lancelet
XP_006811114 220 dd-nvPFYSRAALkgyg----wlkdKVLSEEGRRQQAKLREVTIIADRIGCTLPQLAIAWCLKNEAVSSVILGASNTDQL 294 Saccoglossus ko...
OWF37716     275 dd-gvPIYSRAALkgyv----wlkeKILSEDGRRQQAKLREVAIIADRIGCSLSQLAIAWGLKNDNVHCVLLGASSVDQL 349 Yesso scallop
XP_023228406 278 de-gvHLLSRGSVknftmlqdkhlgADLDGRSPRHQSKLQELAFLAEKLGCTSTQLTVAWCLKNDGVHCVLVGASTTEQL 356 bark scorpion
EDV24247     219 mddtiPEDSRASLsnfd----wwreKIQSEEGRRMQAKLKELQIIADRIDCTLCQLAIAWCLKNDRANCVLLGAKNSHQL 294 Trichoplax adha...
ESN91839     226 kn-glPANSRASIknfs----wykeRVTNEQAARHHLLLNDLEMIASKLDCTLAQLAIAWCLKNENVHCVVLGSSSVEQL 300 Helobdella robusta

Feature 1         ##              
3EAU_A       297 MENIGAIQVLPKLSSSI 313 Norway rat
1ZSX_A       318 MENIGAIQVLPKLSSSI 334 human
Q14722       383 IENLGAIQVLPKMTSHV 399 human
O43448       372 IEHLGALQVLSQLTPQT 388 human
XP_002130946 295 MENLKSIKLIPQITNLE 311 Ciona intestinalis
EEN70106     311 YENIQALQVVQKLTPQI 327 Florida lancelet
XP_006811114 295 YENLQAIRFVPKLTPQI 311 Saccoglossus kowalevskii
OWF37716     350 YENIQAIQYVPKLTADI 366 Yesso scallop
XP_023228406 357 YDHLQALQIVPKLTPNV 373 bark scorpion
EDV24247     295 KENITAIAILPKLDHSM 311 Trichoplax adhaerens
ESN91839     301 IENLKAVQVRIELTQNN 317 Helobdella robusta

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