1AM9


Conserved Protein Domain Family
bHLHzip_SREBP1

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cd18921: bHLHzip_SREBP1 
Click on image for an interactive view with Cn3D
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 1 (SREBP1) and similar proteins
SREBP1, also termed Class D basic helix-loop-helix protein 1 (bHLHd1), or sterol regulatory element-binding transcription factor 1 (SREBF1), is a member of a family of bHLHzip transcription factors that recognize sterol regulatory element 1 (SRE-1). It acts as a transcriptional activator required for lipid homeostasis. It may control transcription of the low-density lipoprotein receptor gene as well as the fatty acid. SREBP1 has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').
Statistics
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PSSM-Id: 381491
Aligned: 10 rows
Threshold Bit Score: 126.93
Created: 17-Jan-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA bindingdimer interface
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLHzip mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Structure:1AM9; Homo sapiens SREBP1 bHLHzip binds DNA, contact at 4.0.
    View structure with Cn3D
  • Citation:PMID 9634703

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #     # ### ## ###   #                 ##                                  
1AM9_A          1 QSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGTEAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLSLRTAVHK 75   human
NP_001098599  313 PHKGEKRTAHNAIEKRYRSSINDKIIELKDLVAGTEAKLNKSAVLKKAIEYIRYLQQSNQKLKQENMALKMNIQK 387  zebrafish
XP_002935886  404 NGKGEKRTAHNAIEKRYRSSINDKIIELKDLVVGNEAKLNKSAVLKKAIDYIRFLQQNNIKLKQENMMLKMAAQK 478  western clawed frog
AAK50343      295 QSKGEKRTAHNAIEKRYRSSINDKIVELKDLVVGTEAKLNKSAILRKAIEYIRFLQQSNQKLKQENLSLKMAVQK 369  chicken
AHB60716      301 PKKGEKRTSHNAIEKRYRLSINDKIIELKDLVAGTEAKLNKSAILKKAIDYIRYLQNTVQRLKQENMALKMASQK 375  noble scallop
ELT88175       22 GGRGEKRTAHNAIEKRYRLSINDKIIELKDLVVGPEAKLNKSAVLRKACDYIRFLHASNARLKQENMALKMAAQH 96   Capitella teleta
P36956        319 QSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGTEAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLSLRTAVHK 393  human
XP_014344253  290 QNKGEKRTAHNAIEKRYRSSINDKIIELKDLVVGSEAKLNKSAVLRKAIDYIRFLQQTNQKLKQENVTLKMVTQK 364  coelacanth
XP_007903954  282 PNKGEKRTAHNAIEKRYRSSINDKIVELKELIVGTESKLNKSAILRKAVDYIRFLQHSNQKLKHENTALRMAVQK 356  elephant shark
XP_013400121  261 PPKGEKRTAHNAIEKRYRLSINDKILELKDLVSGTDAKLNKSAVLRKAIEYVKYMQQQNNRLKQENMALKMALKK 335  Lingula anatina

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