Conserved Protein Domain Family
bHLH-PAS_NPAS4_PASD10
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cd19697: bHLH-PAS_NPAS4_PASD10 
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 4 (NPAS4) and similar proteins
NPAS4, also termed neuronal Per-Arnt-Sim homology (PAS) factor 4, or neuronal PAS4, or Class E basic helix-loop-helix protein 79 (bHLHe79), or HLH-PAS transcription factor NXF, or PAS domain-containing protein 10 (PASD10), is a bHLH-PAS neuronal activity-dependent transcription factor which heterodimerizes with ARNT2 to regulate genes involved in inhibitory synapse formation.
Links
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Statistics
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PSSM-Id: 381540
Aligned: 22 rows
Threshold Bit Score: 93.1378
Created: 28-Jun-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus NPAS3 (5SY7)-ARNT complex binds HRE DNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          ###   # ##   #                    ##                   
Q8IUM7         2 YRSTKGASKARRDQINAEIRNLKELLPLAEadKVRLSYLHIMSLACIYTRKGVFFAG 58   human
ETE58277       2 YRSTKGASKARRDQINAEIRHLKDLLPIAEgdKLRLSYLHIMSLACIYTRKSIFFSK 58   king cobra
KZS19817      14 SKSTKGASKLRRDLINTEIGHLRDLLPLPAstRQRLSQLQLMALVCVYVRKANYFQQ 70   Daphnia magna
AGX25235      56 FRSTKGASKQRRDLINAEISLLRGHLPLAEpvRARLSYLQVMSLTCVYMRKCNYFSR 112  Florida lancelet
EEC15867      20 NKSTKGASKLRRDLINAEIANLRDLLPLPSstRQRLSQLQLMALVCVYVRKANYFQH 76   black-legged tick
PAA75882       4 GLFPKLTSKVRRESINREIVELKKCLPLPRsiTKKLSYLHILSLTNTYLKKLMHMPP 60   Macrostomum lignano
NP_001097936 154 NKSTKGASKMRRDLINAEIANLRDLLPLPQstRQRLSQLQLMALVCVYVRKANYFQQ 210  fruit fly
XP_006814218  88 FRSTKGASKQRRDLINAEIKNLRDLLPLPDsvKARLSYLHVMSLACVYTRKCNFFSQ 144  Saccoglossus kowalevskii
XP_011675866   2 QRSTGKASKLRRDQINSEIETLRHLLPLPSavKARLSYLQVMSLACVYIRTGNFFSS 58   purple sea urchin
GAV03823      20 DRSSKRQSKQRRDLINAEMNVLRDLLPFPVatRHRLSQLQLMACLCVYIRKCTTLAQ 76   Ramazzottius varieornatus

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