2AFC,5M3I,2L8R,2LGR,4J5Q,4J5R,2EEE,5M31,2FG1,2AFC,5E3B


Conserved Protein Domain Family
Macro_Poa1p-like

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cd02901: Macro_Poa1p-like 
Click on image for an interactive view with Cn3D
macrodomain, Poa1p-like family
Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. Members of this family show similarity to the yeast protein Poa1p, reported to be a phosphatase specific for Appr-1"-p, a tRNA splicing metabolite. Poa1p may play a role in tRNA splicing regulation.
Statistics
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PSSM-Id: 394873
Aligned: 45 rows
Threshold Bit Score: 104.642
Created: 20-Sep-2005
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
ADP-ribose
Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:ADP-ribose binding site [chemical binding site]
Evidence:
  • Structure:4J5R: human TARG1 (C6orf130), terminal ADP-ribose glycohydrolase 1, binds DP-HPD, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              ####            ####     ####### #                                        
2AFC_B         2 EILYIKGDATapig-sgvKVITHICNDi--GGWGKGFVLALSkkwkxPEEAYRQWYksqe---eftlGAVQFVNVENk-- 73  Bacteroides the...
5M3I_A        11 MITYGSGDLLra----dtEALVNTVNCv--GVMGKGIALQFKrrypeMFTAYEKACkrge----vtiGKMFVVDTGQld- 79  Mycobacterium t...
4J5R_A         7 RITYVKGDLFacp---ktDSLAHCISEd--CRMGAGIAVLFKkk-fgGVQELLNQQkk--------sGEVAVLKRDG--- 69  human
5M31_A        11 MLRFVRGNLLea----pvEALVNTVNTv--GVMGKGVALQFKrafpdNYQAYVKACergq----vqiGRIFVYDRGPla- 79  Thermus aquatic...
5E3B_A        23 EISYVRGDATapsv-kgvKMIAHVCNDl--GGWGKGFVLAVSrrwpqPEAAYRAWHrdraa-ndfglGAVQFVQVEPy-- 96  Streptomyces co...
NP_004275    716 SLKYVSGDVThpqagaedALIVHCVDDs--GHWGRGGLFTALe---kRSAEPRKIYelagkmkdlslGGVLLFPVDDkes 790 human
NP_250437      1 MIREVEGDILls----gaQVIAHGIAPq--DHFDSGLALALRerwpsMVRDYRHAAhara----pepGGIWVWAGVDeqg 70  Pseudomonas aer...
ABA88605       3 EIFGDLWSWHgra--iiaITTGGQVSSkghCSMPRGCARQTKe----RYPEISAVL-----------GEMIRSHGNQvfd 65  Pelobacter carb...
AAR35749       7 NIWDHLGTAIic-----iTTNGHLTKKg-eAVLGRGCARQARe----RFPDLPARL-----------GAVLSEGGNHvhv 65  Geobacter sulfu...
YP_001635569 229 KLSWVDGDMFfs----kmQTLTISVNTv--GVMGKGLASRAKyqfpdVYVIYQDVCkngt----lqmGKPYLYKREGsld 298 Chloroflexus au...
Feature 1                               ##                                        ########       
2AFC_B        74 ----------------LYVANXIGQHgiykds-kglppiRYDAVRQCLKEVALFTi-aHKASVHXPRIGCGLAGgkWELX 135 Bacteroides the...
5M3I_A        80 --------------gpKHIINFPTKKhwr-------apsKLAYIDAGLIDLIRVIrelNIASVAVPPLGVGNGGldWEDV 138 Mycobacterium t...
4J5R_A        70 ----------------RYIYYLITKKras-------hkpTYENLQKSLEAMKSHClknGVTDLSMPRIGCGLDRlqWENV 126 human
5M31_A        80 --------------qpRYIFNFPTKKhwr-------hpsRMEYVEEGLKDLVCRIqelRVRSIALPPLGAGNGGlpWPEV 138 Thermus aquatic...
5E3B_A        97 ----------------VWVANMIGQHgmktgs--kgapvRYEAIGTALGRVADRAa-eLEASVHLPRIGCGLAGgtWSRV 157 Streptomyces co...
NP_004275    791 r-----------nkgqDLLALIVAQHrdrsn---vlsgiKMAALEEGLKKIFLAAk-kKKASVHLPRIGHATKGfnWYGT 855 human
NP_250437     71 --------------ktQCIVNLITQGmlhsgrsakpgkaSLEDVGHALRELARYVrseGVSSLALPCVATGVGGldWSEV 136 Pseudomonas aer...
ABA88605      66 --------------lgHGIVSFPVENspf-------evpDLRLIERSCVQLKDLTdrnAWPLVILPRPGCGGGGlsWKEV 124 Pelobacter carb...
AAR35749      66 --------------igEGLVSFPVEEspw-------anpDLRLIRRSAEELRALAdreGWTRVIVPRPGCGGGGlaWQDV 124 Geobacter sulfu...
YP_001635569 299 edladeplslphpnasKWFLLFPTKRhwk-------ersDREGIEKGLQWLVSHYrdeGIQSIAIPALGCGLGGldWKEM 371 Chloroflexus au...
Feature 1                   
2AFC_B       136 EQIIKEELITK 146 Bacteroides thetaiotaomicron
5M3I_A       139 EQRLVSAFQQL 149 Mycobacterium tuberculosis
4J5R_A       127 SAMIEEVFEAT 137 human
5M31_A       139 KQRIQEALEAL 149 Thermus aquaticus Y51MC23
5E3B_A       158 EPLISDRLTRR 168 Streptomyces coelicolor A3(2)
NP_004275    856 ERLIRKHLAAR 866 human
NP_250437    137 KPLVVRHLGDL 147 Pseudomonas aeruginosa PAO1
ABA88605     125 RPVLEKHLDDR 135 Pelobacter carbinolicus DSM 2380
AAR35749     125 RPLLADILDDR 135 Geobacter sulfurreducens PCA
YP_001635569 372 GPLICRYMVQM 382 Chloroflexus aurantiacus J-10-fl

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