Conserved Protein Domain Family

pfam00096: zf-C2H2 
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Zinc finger, C2H2 type
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.
PSSM-Id: 395048
Aligned: 159 rows
Threshold Bit Score: 25.7237
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Aligned Rows:
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Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
P07664  223 HICPICGVIRRDEEYLELHMNL-H 245  fruit fly
P07664  405 GFCLICNTNFENKKELEHHLQFdH 428  fruit fly
P24349  233 SSCHLCHLPV-PNKFLEAHGNV-H 254  Caenorhabditis elegans
P07664  308 IICSICNVSFKSRKTFNHHTLI-H 330  fruit fly
P20385   74 HYCPMCHQQFERPQHVADHMQLcH 97   fruit fly
P08970  523 FPCEQCDEKFKTEKQLERHVKT-H 545  fruit fly
P08970  319 FPCSICNANLRSEALLALHEEQ-H 341  fruit fly
P18739    1 FSCSQCDESFVQRSELELHRQL-H 23   African clawed frog
P23607  542 FKCDICLLTFSDTKEVQQHALV-H 564  house mouse
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