4N1Y,5UC1,2J7X


Conserved Protein Domain Family
Hormone_recep

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pfam00104: Hormone_recep 
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Ligand-binding domain of nuclear hormone receptor
This all helical domain is involved in binding the hormone in these receptors.
Statistics
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PSSM-Id: 395054
Aligned: 323 rows
Threshold Bit Score: 37.7155
Threshold Setting Gi: 14917017
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4N1Y_A        29 GQPPT---KVHLLNSLVKLAERELVHL----INWA-KNVPGYT-DLSLSDQVHLIECCWMELLLLNCAFRSIEHGGKSLA 99  Pacific oyster
EGT31058     118 FQKEGripKTANYKELNELCSIDLDLIivnyTSMLqSITP-----TDEEQRRLLGIQFLVPFCLLDGAF---RSQYVDSD 189 Caenorhabditis ...
Q18395       124 YGEKIce---iNFTQFSSFVKRDTHLL----WDLGeKIFTDVKl-LSEADKHSILCNFFPRWMMLDSAVAICPDYEESKA 195 Caenorhabditis ...
XP_003115903 144 YGKRLde---vTYYETCLATKNDVEIM----LSVIeMIFPQLIe-LSTWDKNSLLRNFYPKWALLVAAI---DFERNRAV 212 Caenorhabditis ...
EFO95493     121 rihMFsslGLQNVYAITSLTKNDTSLT----EDLVtDVFPDLGk-LSSNDKRSLINGFVLKLWQIEPAL---DHVANRVE 192 Caenorhabditis ...
XP_002638155 124 SREKTdw---lNIYEISCMIRMDINLT----WKMVdKMFPLSRk-LDDSDKKALLRHFILKFWQIWPIF---DCIKNTED 192 Caenorhabditis ...
O62031       132 RNYMTrtlDETNYYQLSCFKIEDCMMI----WRIVeDLFPSLTwNLRKLDKEALLRNFLPKWSVLTAAIDMEVKVQRYSK 207 Caenorhabditis ...
XP_002633421 229 FGSTGipiVKATRETVFEIYQKQLELL----HIFLrSTFSEYE-ECDVPEQKRICALFYPVLWEIESCYWTYRNMPATSD 303 Caenorhabditis ...
NP_507194    120 NNGVFde---lNVFELSCSVSKDIDLT----WKMIyKLFPSTGk-LKKSDKIALLRNFIPKLWQIDPLL---NYIRNFKK 188 Caenorhabditis ...
NP_504765    114 H--KTspaKKVNFYEYSSIAIIDSRIV----WNLLeRTFLELKv-LDDIDKFNLFSNFYPKWTLFESAI---TALQKSDV 183 Caenorhabditis ...
4N1Y_A       100 FAPDLVLD------------------------RSSWSTVEMTEIFEQVA----------AVSEQMMQNHLHKDELLLLQA 145 Pacific oyster
EGT31058     190 LFLMPNGDyvelek-------------lnkfyENPEENDKSIAGGVTSLmrpywrlnnqVLRNELKSVLLDLSEFLFVSA 256 Caenorhabditis ...
Q18395       196 YIKSKDYTdmll----------------hfygSSMPKEKRLKDHEILKIfkpywdfhyyETAVPIHFKKLDKIEYMAIFL 259 Caenorhabditis ...
XP_003115903 213 FEGYCTTIvdyygm------------vikfysQSMYDNCQIEPNEILRIfepyhryyafDLALPICGKDFNAVEYMAVAL 280 Caenorhabditis ...
EFO95493     193 YRKMEEKDiqnii--------------fpffnGSFMKGSELSEDDIWRIfgphwiyffeKVIEPIVSLSLDRIELMAVIW 258 Caenorhabditis ...
XP_002638155 193 YESMKKNNyekmi--------------vgwygGCFKEGKEMSNNEIIRVfepfwstfysQIVPPIIGLKLENEELMAIVW 258 Caenorhabditis ...
O62031       208 VNNTEEFKrmiv----------------dfftYSMPEKFKMPPEDILKVfgpmivyyvtKIILPIHEKGLDQPEFMALAL 271 Caenorhabditis ...
XP_002633421 304 CEHFLMCTqttyidvrdveywlgntdgnsaedINTIKTRLERLLQTART----------SILDRMHKLIIKEFEFVTVLA 373 Caenorhabditis ...
NP_507194    189 YEAMEQPDleqii--------------infykGAMPEKGSMTDSEIVRIfkpfwsfyfhNMIQPIIFMKLKEQEFMAIIW 254 Caenorhabditis ...
NP_504765    184 HTFFAPNGkpaqq--------------iskfyKDCMTGLRMKDTEVLRIfepywnsyysHVAYPLFELKFDQMEHMALLA 249 Caenorhabditis ...
4N1Y_A       146 MVLv--------------------nAEVrrL--ASY--NQIFNMQQSLLDAIvdtaQKy-----------HPDnvrHVPA 190 Pacific oyster
EGT31058     257 LIFwd------------------fgITN--Q--SEEciQICKQMRSRVIEEL----TSyeksi---rkddHPM---RVGA 304 Caenorhabditis ...
Q18395       260 LLLfd------------------daYTN--I--SEEgvKLCQNVRKVVQREL----KGyqtd----sncdE-M---RFVE 305 Caenorhabditis ...
XP_003115903 281 MAFfd------------------gaHTN--I--SSEcaDLCHNVKNIVLREL----RGyyad-----rnvEEM---RFIE 326 Caenorhabditis ...
EFO95493     259 ILFfdhgiiylslksllssifflsaYID--I--SSKsiDLCWNIRKVIHREL----KNylvekigdeeaaE-M---RFMD 326 Caenorhabditis ...
XP_002638155 259 LLFfd------------------naYTN--I--SQEceEICRNIKKVILREL----KNyqid----knfeE-M---RLLD 304 Caenorhabditis ...
O62031       272 IILfd------------------gaYSN--I--SVEcsEMCRTIRNLIFREL----KNyqtd----knfdEI----QFAD 317 Caenorhabditis ...
XP_002633421 374 ln---------------------iwAPR--NhqQSCldKAADHVRTTLFDDL----HYlyhde--lrienYAG---RMGE 421 Caenorhabditis ...
NP_507194    255 LMFfd------------------ngYSN--I--SDEclEMCWNIRKVILREL----RNyqid----gnceE-S---RLFE 300 Caenorhabditis ...
NP_504765    250 LMLmd------------------pgYTN--I--SDEcvEMCHRFRKVIQMEL----KGyyle----knsdP-E---RILK 295 Caenorhabditis ...
4N1Y_A       191 VLLLLTHIRQAGERGIAFFQRLKS 214 Pacific oyster
EGT31058     305 VVMVLQAVQKAYGIMDECRDISMV 328 Caenorhabditis brenneri
Q18395       306 TMDTLLLLEKAEEKIQEEVLICGF 329 Caenorhabditis elegans
XP_003115903 327 TIDVLQLMQKGESKFQEELLVCEM 350 Caenorhabditis remanei
EFO95493     327 ILEIPMIVERGEQKFLDEFIICEL 350 Caenorhabditis remanei
XP_002638155 305 TVETLELIEKSEQKFLEEMMICEM 328 Caenorhabditis briggsae
O62031       318 TVDTLNIVEKGEKKFYEELLICDM 341 Caenorhabditis elegans
XP_002633421 422 IMCLFTEV--------QTADLSST 437 Caenorhabditis briggsae
NP_507194    301 TLESLEYIEKGERKLMEEMLICEI 324 Caenorhabditis elegans
NP_504765    296 VIEALLLMEKADQWFQEEVHMCGV 319 Caenorhabditis elegans
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