6GV3,3RCZ,5JNE,2UCZ,6OP8,3FSH,6NYA,5KNL,4R62,4YII,2Y9M,3O2U,6QHK,2KJH


Conserved Protein Domain Family
UQ_con

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pfam00179: UQ_con 
Click on image for an interactive view with Cn3D
Ubiquitin-conjugating enzyme
Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologs. TSG101 is one of several UBC homologs that lacks this active site cysteine.
Statistics
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PSSM-Id: 395127
Aligned: 64 rows
Threshold Bit Score: 104.197
Threshold Setting Gi: 54035927
Created: 16-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6GV3_A  29 RLAEERKswrKNHPHGFVAKPET--GqdgtvNLMVWHCTIPGKAGTDWEGGFFPLTMHFSEDYPSKPPKCKFPQGFFHPN 106 thale cress
3O2U_B  33 RLKRDLDs-lDLPPTVTLNVITSpdSad-rsQSPKLEVIVRP-DEGYYNYGSINFNLDFNEVYPIEPPKVVCLKKIFHPN 109 baker's yeast
O74549  27 RIQKDVTd-lEIPSTMSTSWpd-------piKLNVLHLEIRP-DEGYYKGGKFKFRIQIDDNYPHDPPKVKCLNKIYHPN 97  Schizosaccharomyces p...
Q9VSF3  30 RIQKDINe-lNLPNTCATDFpd-------pnDLLNFKLIISP-DEGFYRDGRFVFNFRVGSNYPHEPPKVKCATQVYHPN 100 fruit fly
Q9ZU75  35 RLHKDISe-lNLPKSCKISFpng------knDLMNFEVTIKP-DEGYYLSGNFVFSFQVSNMYPHEAPKVKCKTKVYHPN 106 thale cress
P61082  33 RIQKDINe-lNLPKTCDISFsd-------pdDLLNFKLVICP-DEGFYKSGKFVFSFKVGQGYPHDPPKVKCETMVYHPN 103 house mouse
Q9VGD6  17 RLDRDVN---RLLASGYRTTVDD--------DMTNLNVCLEGPLGSAYEGGIWTVNVTMPQDYPLTAPRVRFVTKILHPN 85  fruit fly
P42749   7 RREMDLM---KLMMSDYKVEMIN--D-----GMQEFFVEFSGPKDSIYEGGVWKIRVELPDAYPYKSPSVGFITKIYHPN 76  thale cress
P42750   7 RREMDMM---KLMMSDYKVDTVN--D-----DLQMFYVTFHGPTDSLYQGGVWKIKVELPEAYPYKSPSVGFVNKIYHPN 76  thale cress
P28263   7 RIETDVM---KLLMSDHQVDLIN--D-----SMQEFHVKFLGPKDTPYENGVWRLHVELPDNYPYKSPSIGFVNKIFHPN 76  Saccharomyces cerevis...
6GV3_A 107 VY-PSGTVCLSILNeDygWRPAITVKQILV-GIQDLLDTPNPADPAQTDGYHLFCQDPVeyKKRVklQS 173 thale cress
3O2U_B 110 ID-LKGNVCLNILR-Ed-WSPALDLQSIIT-GLLFLFLEPNPNDPLNKDAAKLLCEGEKefAEAVrlTM 174 baker's yeast
O74549  98 ID-IEGNVCLNILR-Qd-WNPVLNLNSILV-GLQFLFLSPNAEDPLNKEAAADLHKDPQgfASRVrtAM 162 Schizosaccharomyces pombe 972h-
Q9VSF3 101 ID-LDGNVCLNILR-Ed-WNPVLNINSIVY-GLQFLFLEPNPEDPLNKEAADVLQTNRRqfENNVkkAM 165 fruit fly
Q9ZU75 107 ID-LEGNVCLNILR-Ed-WKPVLNINTVIY-GLFHLFTEPNYEDPLNHEAAAVLRDNPKtfEYNVrrAM 171 thale cress
P61082 104 ID-LEGNVCLNILR-Ed-WKPVLTINSIIY-GLQYLFLEPNPEDPLNKEAAEVLQNNRRlfEQNVqrSM 168 house mouse
Q9VGD6  86 IEfITGLVCMNVLKq--aWSSSYDLVNIFEtFLPQLLRYPNPHDSLNHRAAAIMKHSEQlfREHVilCM 152 fruit fly
P42749  77 VDeMSGSVCLDVIN-Qt-WSPMFDLVNVFEtFLPQLLLYPNPSDPLNGEAAALMMRDRPtyEQRVkeYC 143 thale cress
P42750  77 VDeSSGAVCLDVIN-Qt-WSPMFDLINVFEsFLPQLLLYPNPSDPFNGEAASLLMRDRAayELKVkeYC 143 thale cress
P28263  77 IDiASGSICLDVIN-St-WSPLYDLINIVEwMIPGLLKEPNGSDPLNNEAATLQLRDKKlyEEKIkeYI 143 Saccharomyces cerevisiae S288C
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