4GWN,2C9A


Conserved Protein Domain Family
MAM
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pfam00629: MAM (this model, PSSM-Id:395504 is obsolete and has been replaced by 459878)
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MAM domain, meprin/A5/mu
An extracellular domain found in many receptors. The MAM domain along with the associated Ig domain in type IIB receptor protein tyrosine phosphatases forms a structural unit (termed MIg) with a seamless interdomain interface. It plays a major role in homodimerization of the phosphatase ectoprotein and in cell adhesion. MAM is a beta-sandwich consisting of two five-stranded antiparallel beta-sheets rotated away from each other by approx 25 degrees, and plays a similar role in meprin metalloproteinases.
Links
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Statistics
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PSSM-Id: 395504
Aligned: 63 rows
Threshold Bit Score: 103.229
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4GWN_A     204 CSFELEn---VCGMi-QSSGDNADWQRVS----QVPRGPESDHSnmgqCQGSGFFMHFDSSsvNVGA--TAVLESRTLYP 273  human
Q1RLY9     637 CDFGWAndpsFCGWisEDS--GFRWQIQSsgtpTLNTGPNMDHT-----GGSGNFIYTLATgaQETE--VARLVSPSVSG 707  zebrafish
Q9QWJ9     650 CEFGWGshktFCHWe-HDSHAQLRWRVL-----TSKTGPIQDHT------GDGNFIYSQADenQKGK--VARLVSPVVYS 715  Norway rat
P79795     641 CGFGWGshktLCQWe-HDNQVDLKWAIL-----TSKTGPIQDHT------GDGNFIYSQADesQKGK--VARLLSPIIYS 706  chicken
CAF97210   496 CDFEQS----LCGWs-ADPLSGVSWSLHTa--sSGSTGHGTHGF-------SGNYLHLDAG--AHIQrkRARLLSPEVGP 559  spotted green pu...
AAI63589   630 CDFEQS----MCGWt-HDPMSDLKWSMYSssspSLDLTHGPDNF--------GNFLYVEAS--PMSEpqRARLLSPSVGP 694  zebrafish
O60462     646 CNFDFLe--ePCGW----MYDHAKWLRTT----WASSSSPNDRT----FPDDRNFLRLQSDsqREGQ--YARLISPPVHL 709  human
OCA23257   641 CNFDHSd--dVCSWt-HDTNADFTWSFHPhspwMGHSGSVAGNS--------KHYLRLPSTgrREGQ--HARLLSPKMYL 707  tropical clawed ...
ABD14587    36 CSFDIPn--dLCDWtwIPTASGAKWTQKKgssgKPGVGPDGDFS----SPGSGHYMLLDPKnaRPGQ--KAVLLSPVSPS 107  Rhesus monkey
NP_035871  217 CTFDTLn--dLCGWswVPTATGAKWTQKKgptgKQGVGPAEDFS----NPGNGYYMLLDSTnaRPGQ--KAVLLSPLSHS 288  house mouse

4GWN_A     274 KRGFQC--LQFYLYNSGSE-SDQLNIYIREYSADnvdgnltLVEEIKEIPTGSWQLYHVTLKV---TKKFRVVFEGRkGS 347  human
Q1RLY9     708 QDSDLC--LSFWYHMFGSH-IGTLHIKQRRETSQgsa--dvLLWTVSGHQGNRWREGRVLIPHs--NKPYQVIIESV-VE 779  zebrafish
Q9QWJ9     716 QSSAHC--MTFWYHMSGSH-VGTLRVKLHYQKPEey---dqLVWMVVGHQGDHWKEGRVLLHKs--LKLYQVIFEGE-IG 786  Norway rat
P79795     707 QNSAHC--MTFWYHMSGPH-VGTLKIKLRYQKPDey---dqVLLSLNGHQANCWQEGRVLLHKs--VKLYQVVIEGE-IG 777  chicken
CAF97210   560 EQGPLC--LVFYYQLQGEA-QGSLRVLLKDSEQEe-----tLLWALKGEQGSHWREGRTILPQs--PKEYQVVFEGF-FD 628  spotted green pu...
AAI63589   695 ERRLVC--LLFYYQLRGAG-QESLRVLLRDDDQEe-----tLLWTLKGDQGSMWREGRTILPQs--PKEYQVVIEGF-FE 763  zebrafish
O60462     710 PRSPVC--MEFQYQATGGR-GVALQVVREASQESk------LLWVIREDQGGEWKHGRIILPSy--DMEYQIVFEGV-IG 777  human
OCA23257   708 PRTVLC--MVFRYRASGSS-GGTLQVLRKSSLENr------LLWQMKEEQESDWREGRIILNSskgEEEYQVVIDGI-VG 777  tropical clawed ...
ABD14587   108 SGC-LS--FSFHYVLRGQSpGAALHVYASVLGSIrk----hTLFS--GQPGPNWQAVSVNYTA---VGRIQFTVVGV-FG 174  Rhesus monkey
NP_035871  289 R---GCmtLSFHYIMHGQGhEEGLFVYATFLGNIrk----yTLFS--GHPGPDWQAVSVNYTG---QGQIQFMVVGM-FG 355  house mouse

4GWN_A     348 GASLGGLSIDDINl----SETRCP 367  human
Q1RLY9     780 RKSWGDIAVDDIKildnvNMADCK 803  zebrafish
Q9QWJ9     787 KGNLGGIAVDDISinnhiPQEDCA 810  Norway rat
P79795     778 KGN-GGIAVDDINidnhiSQEDCQ 800  chicken
CAF97210   629 HPTRGHIKIDNIHmssniQLEECT 652  spotted green pufferfish
AAI63589   764 RGSRGHIRIDNIHmsssiDLEQCT 787  zebrafish
O60462     778 KGRSGEIAIDDIRistdvPLENCM 801  human
OCA23257   778 KGQPGEIAVDDIRiatdiPVEHCM 801  tropical clawed frog
ABD14587   175 KTPEPAVAVDATSi------APCG 192  Rhesus monkey
NP_035871  356 NIPEPAIAVDAISi------APCG 373  house mouse
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