3HB0,3J09,3SKX,6Q6J,3M1Y,1F5S,1NRW,1WR8,2OM6,4JDP,3PDW,1ZJJ,1AQ6,2NO4,1JUD,3WK8,1CQZ,6Q7Q,2HOQ,3ONN,3I76,2YY6,2QLT,1TE2,3NAS,4G9B,1Z4N


Conserved Protein Domain Family
Hydrolase
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pfam00702: Hydrolase (this model, PSSM-Id:395571 is obsolete and has been replaced by 459910)
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haloacid dehalogenase-like hydrolase
This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Pseudomonas sp. (S)-2-haloacid dehalogenase 1. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteristic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.
Links
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Statistics
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PSSM-Id: 395571
Aligned: 227 rows
Threshold Bit Score: 32.1728
Created: 16-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3HB0_A   4 ERVFVWDLDETIIIFHSLLTGTFASRygkdtttsvriglmmeemifnladthlffndlEDCDQIhvdDVSSDDNGQdlst 83  human
O33512   2 APALIFDLDGTLIDSAPAIHKVSNDVl-------------------------------RARGYA---PLGLDQIRS---- 43  Rhodobacter capsulatus
P95650   1 MPGVVFDLDGTLVHSAPDIHAAVNKAl-------------------------------AEEGGA---PFTLAEITG---- 42  Luteovulum sphaeroides
O51619   3 IKACIFDMDGTLVNSIMDIAFSMNSAl-------------------------------SNLGYS---KIELSKFNA---- 44  Lyme disease spirochete
O83565   5 TRACIFDLDGTLTNTLGTIAYFVNMQa-------------------------------AHYHLP---PIPSEKFAL---- 46  Treponema pallidum
O29334  19 FELIAFDLDGTLIELN------------------------------------------IPFDEIrreLGIEGRFIL---- 52  Archaeoglobus fulgidus
Q12486  13 IKAVVFDMDGTLCLPQPWMFPAMRNA--------------------------------IGLEDK---SIDILHFID---- 53  Saccharomyces cerevis...
P28624   5 VQALLLDMDGVMAEVSQSYRQAIIDT--------------------------------ARHFGV---SVTHEDIDH---- 45  Phytophthora parasitica
O05163  10 WAIAVFDIDGVVRDVSRSYRRALADTvehftdggyrpt---------padidrlkgegSWNNDWkasEELIYRYYE---- 76  Synechococcus elongat...
P74697   4 EKIIVFDLDGVLIDSEEANYQAFAYGi-------------------------------EQLGLP---RPDRQTVVS---- 45  Synechocystis sp. PCC...

3HB0_A  84 ynfsadgfhssapaanlclgSGVHGGVDWMRKLafryrrvkemyntYKNNVGGLIGTPKRETWL--QLRAELEAL--TD- 158 human
O33512  44 --------------------FVGQGAPHLVRCL-------------LTTAGEDPEGPLFDAIYA--DLVSRYETDv-EGn 87  Rhodobacter capsulatus
P95650  43 --------------------FIGNGVPVLIQRV-------------LAARGEAPDAHRQAELQG--RFMAHYEADpaTLt 87  Luteovulum sphaeroides
O51619  45 --------------------LVGRGFNKFVIDTlkl--------lsLEHDNPNLQEKLYKEFVK--EYNKNLSFQ--TK- 91  Lyme disease spirochete
O83565  47 --------------------FLGDGSRALIQRV-------------LAHYGAAAQTISEDEFLQryCLAYEADFL--QRc 91  Treponema pallidum
O29334  53 --------------------ESIMDEKDLQRRQ-----------------------EMLRVLESy-ELRCAMEAR----- 83  Archaeoglobus fulgidus
Q12486  54 --------------------TLPTEKEK--------------------------KEAHDRIELV--EAKAMKEMQ----- 80  Saccharomyces cerevis...
P28624  46 --------------------TKLAGNANNDWQLthrlvvdglngasSAPTLEAVTAQFEALYQGvgNTLGLCELE--TL- 102 Phytophthora parasitica
O05163  77 --------------------SQGRDRNTLALDYeti-------vafFQVRYRGKQPDRPAAWDG--YICDEPLLM--SA- 124 Synechococcus elongat...
P74697  46 --------------------LVGLKASLMLEKL----------------GCPRQEVERIFKDFV--QPFYIENLP--QLa 85  Synechocystis sp. PCC...

3HB0_A 159 -LWLTHSlKALNLINSRpNCvN---VLVTT---TQLIPALAkVLLYG-LGsvfp----ienIYSA---TKTGKESCFERI 223 human
O33512  88 tLYPGVI-TALQRLREM-GC-----PMAIT---TNKPYKPAlAAIAH-VGltdyfqlviggDSLP---TRKPNPEMVNEA 153 Rhodobacter capsulatus
P95650  88 sVYPGAE-AAIRHLRAE-GW-R---IGLCT---NKPVGASR-QILSL-FGllelfdaiiggESLP---QRKPDPAPLRAT 153 Luteovulum sphaeroides
O51619  92 -PYENIK-PLLETMNKL-NI-P---IGILS---NKNHEELI-NLVKNiFGnilff-eirgySKNF---PPKPDPENALDM 156 Lyme disease spirochete
O83565  92 tVYPGVP-EMLVELKRR-RI-E---LAILS---NKPHSIAQ-KVASAfFGdnvfs-vvlgqREGV---PVKPDPAGLFEI 157 Treponema pallidum
O29334  84 -PAYYAV-ELVNGLD---AI-----KGVIT---RNSRRSAE-IVAER-LGfef------dfIIGRedaEPKPSPEPLNLA 142 Archaeoglobus fulgidus
Q12486  81 -PQPGLV-DIMRYLTKN-GI-S---KNICTrnvGAPVETFVkRFIPSeLSrf-------dyIVTRefrPTKPQPDPLLHI 146 Saccharomyces cerevis...
P28624 103 -LTPK---GLLRELHRR----QpkgMAVVT---GRPRKDCA-KFLTT-HGiedlf--pvqiWLEDc--PPKPSPEPILLA 165 Phytophthora parasitica
O05163 125 --------DYLQSLSRA-GI-A---WGFFS---GATPASAR-FVLEQrLGitpt---vliaMGDA---PDKPNPTGLITA 181 Synechococcus elongat...
P74697  86 aPMPNAV-TVLTTLKQR-DY-R---ILACT---SGDRRTQT-AALQG-VGlwsaietmlaaDDSP---FAKPDPRYLQQL 151 Synechocystis sp. PCC...

3HB0_A 224 MQRFg-R--KAVYVVIGDGVEEEQGAKKHN 250 human
O33512 154 RRVLr-R--PH-ALYIGDSEIDAQTAQNAG 179 Rhodobacter capsulatus
P95650 154 AAALn----EEVVLYVGDSEVDAATAEAAG 179 Luteovulum sphaeroides
O51619 157 ILELnaQ--KEEIAYIGDSDVDMLTALNAG 184 Lyme disease spirochete
O83565 158 LRTLnvE--TAEALFVGDTAVDIRTASAAQ 185 Treponema pallidum
O29334 143 LRMFdvS--PSKALMVGDFLFDLLSGKAAG 170 Archaeoglobus fulgidus
Q12486 147 ASKLniR--PLEMIMVGDSFDDMKSGRSAG 174 Saccharomyces cerevisiae S288C
P28624 166 LKALgvE--ACHAAMVGDTVDDIIAGRKAG 193 Phytophthora parasitica
O05163 182 AQQLa-TnpHLPAIYAGDTVADILTVRRAR 210 Synechococcus elongatus PCC 7942
P74697 152 LAPYd----YQTLLHVEDAEVGIRMGQACG 177 Synechocystis sp. PCC 6803
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