4K2I,2FNI,1B9H


Conserved Protein Domain Family
DegT_DnrJ_EryC1

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pfam01041: DegT_DnrJ_EryC1 
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DegT/DnrJ/EryC1/StrS aminotransferase family
The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA, StsC and StsS. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyzes the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin.
Statistics
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PSSM-Id: 395827
Aligned: 21 rows
Threshold Bit Score: 374.698
Threshold Setting Gi: 614098376
Created: 22-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4K2I_B         80 NDEVEDILNTLTEVLPTgkFTS-GPYLEQFEKVLSTYLH-KRYVIATSSGTDAIMIGLLA---LGLN-----PGDEVIMP 149 Bacillus subti...
P26398         40 VIGAKELQLMVEASLDG--WLTtGRFNDAFEKKLGEFIG-VPHVLTTTSGSSANLLALTAltsPKLGeralkPGDEVITV 116 Salmonella ent...
O26434          7 PSIGNEELENVLEALKSgwISSrGEFITKFEEKFARYHG-MGFGISTSNGTTALHLALKS---VGIK-----KGDEVIVP 77  Methanothermob...
Q9KVA5          7 psLDGNERKYLNDCIDSgwVSSrGKYIDRFETEFAEFLK-VKHATTVSNGTVALHLAMSA---LGIT-----QGDEVIVP 77  Vibrio cholerae
Q9ABJ3         27 qTIEEDDIAAVAEALRGdfLTT-GPTVEAFETAFAAKVG-ADHAIAVSNGTATLHLAMMA---LGIG-----EGDVCVAP 96  Caulobacter vi...
CAM00057       28 vgdreRFFARLEWALNNnwLTNgGPLVREFEGRVADLAG-VRHCVATCNATVALQLVLRA---SDVS-------GEVVMP 96  Saccharopolysp...
P9WGJ7         45 fpgpaelAEDFVQIAQAnwYTNfGPNERRFARALRDYLGpHLHVATLANGTLALLAALHVs--FGAGt----RDRYLLMP 118 Mycobacterium ...
P73264         14 DDEIEFFLDEARQILKSgtLIL-GNHTQEFERGFAEFVG-TKNAISVNSGTSGLEILLRLk--QAEN-------TTVLVP 82  Synechocystis ...
jgi:Amir_3287  16 qhDDAERTALLRALDQGqwWRVgGSEVDEFEREFAEYHG-AGHALAVTNGTHALELALQV---LDVG-----PGAEVIVP 86  Actinosynnema ...
1B9H_A         14 qYDDAERNGLVRALEQGqwWRMgGDEVNSFEREFAAHHG-AAHALAVTNGTHALELALQV---MGVG-----PGTEVIVP 84  Amycolatopsis ...
4K2I_B        150 ANSFSATENAVLASGGVPIYVDINPQTFCIDPDKIEEAITPYT-----KFILPVHLYGKHS-DMQHIRQIANRYKLKVIE 223 Bacillus subti...
P26398        117 AAGFPTTVNPAIQNGLIPVFVDVDIPTYNIDASLIEAAVTEKS-----KAIMIAHTLGNAF-NLSEVRRIADKYNLWLIE 190 Salmonella ent...
O26434         78 SLTFAATANAVIYCNAKPVLVDSHPDYWCIDPSRIEEKINKNT-----RAIIPVHLYGHPC-DMGWIGDIADEHGLIIIE 151 Methanothermob...
Q9KVA5         78 TFTYVASVNTIVQCGALPVFAEIEGESLQVSVEDVKRKINKKT-----KAVMAVHIYGQAC-DIQSLRDLCDEHGLYLIE 151 Vibrio cholerae
Q9ABJ3         97 SVTFLATANCARYVGAEVVFADVDPDSGLMTPDTLARALAGARdk-rvKAVLPVHLRGDVC-DLPALKAMASASGAVLVE 174 Caulobacter vi...
CAM00057       97 SMTFAATAHAASWLGLEPVFCDVDPETGLLDPEHVASLVTPRT-----GAIIGVHLWGRPA-PVEALEKIAAEHQVKLFF 170 Saccharopolysp...
P9WGJ7        119 SFTFVGVAQAALWTGYRPWFIDIDANTWQPCVHSARAVIERFRdr--iAGILLANVFGVGNpQISVWEELAAEWELPIVL 196 Mycobacterium ...
P73264         83 TNTNFATVASVLRVNSDVQYLDMDPKTFAPSLAMVKEAVEGKSypkplSGVFWVHIGGVISpEFPAVVDYCHGKGLYVWE 162 Synechocystis ...
jgi:Amir_3287  87 AFTFISSSQAVQRLGAVAVPVDVDPDTYCLDVAAAEAAVTSRT-----SAIMPVHMAGQFA-DMDRLDKLSTSTGVPVLQ 160 Actinosynnema ...
1B9H_A         85 AFTFISSSQAAQRLGAVTVPVDVDAATYNLDPEAVAAAVTPRT-----KVIMPVHMAGLMA-DMDALAKISADTGVPLLQ 158 Amycolatopsis ...
4K2I_B        224 DACQGIG--LTDLG------KYA--DITTLSFNPYKNFgVCGKAGAIATDNEELAKKCI--------QFSYHGfev--nv 283 Bacillus subti...
P26398        191 DCCDALG--TTYEGqm--vgTFG--DIGTVSFYPAHHI-TMGEGGAVFTKSGELKKIIEsfrdwgrdCYCAPGcdntcgk 263 Salmonella ent...
O26434        152 DAAEAHG--AEYRGkk--igTFG--DVSCFSFYGNKII-TTGEGGMCLTNDEELAERMA--------VLRDHGm-----r 211 Methanothermob...
Q9KVA5        152 DCAEAIG--TAVNGkk--vgTFG--DVSTFSFFGNKTI-TSGEGGMVVSNSDIIIDKCL--------RLKNQGv-----v 211 Vibrio cholerae
Q9ABJ3        175 DAPHALGsiATFDGvahpvgDGAysSFASFSFHPVKTL-ATGEGGMLTTNDPALAAKAR--------LLRSHGmvr--qp 243 Caulobacter vi...
CAM00057      171 DAAHALG--CTAGGrp--vgAFG--NAEVFSFHATKAV-TSFEGGAIVTDDGLLADRIR--------AMHNFGia----- 230 Saccharopolysp...
P9WGJ7        197 DSAAGFG--STYADger-lgGRG--ACEIFSFHATKPF-AVGEGGALVSRDPRLVEHAY--------KFQNFGl------ 256 Mycobacterium ...
P73264        163 DTAHAHG--SQLQGkq--agNLA--DGASFSFFPTKVM-TTFEGGMVTLNDDEEDTIAR--------SLRNQGkr----- 222 Synechocystis ...
jgi:Amir_3287 161 DAAHAHG--AHWRGkr--vgELG--SIATFSFQNGKLM-TAGEGGAVLFEDEAQWEKAF--------VLHSCGrp----k 221 Actinosynnema ...
1B9H_A        159 DAAHAHG--ARWQGkr--vgELD--SIATFSFQNGKLM-TAGEGGAVVFPDGETEKYET--------AFLRHScgr--pr 221 Amycolatopsis ...
4K2I_B        284 K--NKKVIN------------FGFNSKMDNLQAAIGLERMKYLSLNNFKRLFLADRYITQLAELQNKGYIELPELSEd-- 347 Bacillus subti...
P26398        264 RfgQQLGSLpqgydhkytyshLGYNLKITDMQAACGLAQLERVEEFVEQRKANFSYLKQGLQSCTEFLELPEATEKSd-- 341 Salmonella ent...
O26434        212 PekRYWHEE------------VGFNYRMTNLQAAVGVAQLEKIDGFINRKREIAEIYNRGLAELHENEELMLHPEMLwar 279 Methanothermob...
Q9KVA5        212 AgkRYWHDL------------VAYNYRMTNLCAAIGVAQLERVDKIIKRKRDIAEIYRSELAGLP----MQVHKESNgt- 274 Vibrio cholerae
Q9ABJ3        244 GgdPWWYEMp----------eLGFNYRIPDVLCALGLSQLAKLDRFVARRRDLTALYARLLAERAPRARLATSPDHSd-- 311 Caulobacter vi...
CAM00057      231 -pdKLVTDV-------------GTNGKMSECAAAMGLTSLDAFAETRVHNRLNHALYSDELRDVRGISVHAFDPGEQn-- 294 Saccharopolysp...
P9WGJ7        257 --vQTRESIq-----------LGMNGKLSEISAAIGLRQLVGLDRRLASRRKVLECYRTGMADAG----VRFQDNANv-- 317 Mycobacterium ...
P73264        223 -gmNFGGLHt----------dFGNSTRMTEIHALLGQIHLAKLERMLATRQKAYELITTPLREAGIEFVSTDHMDRa--- 288 Synechocystis ...
jgi:Amir_3287 222 GdrGYFHLT------------SGSNFRMNEFSAAVLRAQLGRLDSQIATRQARWPVLSALLAGIDGVVPQTVDPRSDrnp 289 Actinosynnema ...
1B9H_A        222 DdrRYFHKI------------AGSNMRLNEFSASVLRAQLARLDEQIAVRDERWTLLSRLLGAIDGVVPQGGDVRADrns 289 Amycolatopsis ...
4K2I_B        348 --hVWHLFPIKVRTe----D-RADIMTKLNEDf-GVQTDVYY-PILSHmQKT-PLVQDKYAGlqLVHTEKAHSQVLHLPL 417 Bacillus subti...
P26398        342 --pSWFGFPITLKEts-gvN-RVELVKFLDEA--KIGTRLLFaGNLIR-QPY-FANVKYRVVgeLTNTDRIMNQTFWIGI 413 Salmonella ent...
O26434        280 -svYWVYSIVLKKRk----N-MD-LIRYLNSC--GVDTRPFF-Y-PLNlMPP-YKDDSSY-----PVAENLSYGGLSLPS 342 Methanothermob...
Q9KVA5        275 -fhSYWLTSIILDQef-evH-RDGLMTFLENN--DIESRPFF-Y-PAHtLPM-YEHLAEKTA--FPLSNSYSHRGINLPS 344 Vibrio cholerae
Q9ABJ3        312 --aALHLLTVLIDFeaegiS-RRTVVESLKTQ--GVGTQVHY--IPVHrQPY-YAQRYGVAd--LPGADAWYARCLTLPL 381 Caulobacter vi...
CAM00057      295 ---NYQYVIISVDSaatgiD-RDQLQAILRAE--KVVAQPYF-SPGCHqMQP-YRTE---PPlrLENTEQLSDRVLALPT 363 Saccharopolysp...
P9WGJ7        318 ---ASLCFASACCTsa--dH-KAAVLGSLRRH--AIEARDYY-NPPQHrHPYfVTNAELVEStdLAVTADICSRIVSLPV 388 Mycobacterium ...
P73264        289 ---SQYKLMVLLPEg----KtPAQMKEALAAEeiYLGGTVYE--IPCHlQPV-FKDVCPGQS--FPNAETWCPRHICPPL 356 Synechocystis ...
jgi:Amir_3287 290 symAMFRMPGVTEErr-naV-VDELVRRGIPA--FMAFRAVYrTQAFWeTGA-PDLTTEELAarCPVSEEITRDCVWLHH 364 Actinosynnema ...
1B9H_A        290 hymAMFRIPGLTEErr-naL-VDRLVEAGLPA--FAAFRAIYrTDAFWeLGA-PDESVDAIArrCPNTDAISSDCVWLHH 364 Amycolatopsis ...
4K2I_B        418 YPSFTLEEQDRVMEGLF 434 Bacillus subtilis subsp. subtilis str. 168
P26398        414 YPGLTTEHLDYVVSKFE 430 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
O26434        343 SVEIGDEAIEYVVDRVR 359 Methanothermobacter thermautotrophicus str. Delta H
Q9KVA5        345 WPGLCDDQVKEICNCIk 361 Vibrio cholerae
Q9ABJ3        382 YPAMTNGDVERVVGALa 398 Caulobacter vibrioides
CAM00057      364 GPAVSSEDIRRVCDIIR 380 Saccharopolyspora erythraea NRRL 2338
P9WGJ7        389 HDHMAPDDVARVVAAVQ 405 Mycobacterium tuberculosis H37Rv
P73264        357 TSGTTPEEATRVGEALV 373 Synechocystis sp. PCC 6803
jgi:Amir_3287 365 RVLLGTEEQlhrlaavv 381 Actinosynnema mirum DSM 43827
1B9H_A        365 RVLLAGEPelhataeii 381 Amycolatopsis mediterranei
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