Conserved Protein Domain Family
EMC3_TMCO1

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pfam01956: EMC3_TMCO1 
Integral membrane protein EMC3/TMCO1-like
This entry represents a group of eukaryotic and archaeal proteins. Eukaryotic members include EMC3, a subunit of the ER membrane protein complex (EMC) required for protein folding, and TMCO1, a ER calcium load-activated calcium channel. Archaeal members may function as insertases of the archaeal plasma membrane.
Statistics
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PSSM-Id: 396507
Aligned: 53 rows
Threshold Bit Score: 81.9433
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q23A34     3 DIVIDHKIRDWVFFPIVIVMIMVTLIRHYLTISGNKVQipKASSKTEqvDVSDKLQLMRCQNLVKHGGLLKEASFNRRKY 82  Tetrahymena thermop...
Q9HPA6   122 NVVLGPLDS---IMPFYVVILVLAVLTGLYTTILQANLtdMEKMSKY--QEQAQELQDKMSAAKERGDDAAVERLREEQM 196 Halobacterium salin...
Q5UXG9   127 DIVLGPLND---MLPFYVVILVLAIITGTTSTILQDNLmdMSGMGDH--QEKMEDLKERRKAAKERDDQEALDRLEEEQM 201 Haloarcula marismortui
Q18GM3   135 DVPLGPLEE---LLPFYAVVMILALATGLYSTLLQANLmnMEKMSAY--QSRMKEIQERRKEAKEEGDDDALDAIQDEQM 209 Haloquadratum walsb...
CAI50547 126 NLLLGPLLD---LLPFFAVVMVLALFTGLYSTLLQSNLmdMEVMGKY--QGRMKEIQERRKEAKERGDDEALERIQEEQM 200
Q9HR70   129 NQLLAPVMN---LLPFHIVVLVLAVTTGVYSTYLQSRLmdHETLQAY--KDRMAALKERREAAKERGDDEALERIQSEQM 203 Halobacterium salin...
Q0W1W2    54 NVVAGPIAS---MMPFYMVVLTIAAIVTLISTFIQKYTidWELMQRM--TIRSRAFQKEYREAQLSGNKHKLKKLQEEQL 128 uncultured methanog...
A0B9U6    39 ELVIGWLPE---ILPFHMVLFVLAAITGLYASLIQKYTmdWDFLREQ--QMRMREFQAELRAAQLAGDQARVQHLQNKQL 113 Methanothrix thermo...
Q8TRR7    41 GVIMDPVLSLVGQENFHLILLVMAIITALYASLIQKYTidWELMRNT--QERMKVFQKEFREAQLSQNTYMLKKLEDQRK 118 Methanosarcina acet...
Q12ZS6    41 GVFMDPISMMVGEGNFHIMLFIMAAITALYASLIQKYTidWDLMRNT--QERMKSFQKEFREAQLSQNTYMVKKLEEQRA 118 Methanococcoides bu...
Q23A34    83 HLCKDRTKGylvergerpapetnnngapqmpmnsnqMMDMLKGNITMAVPMIVLFSWVRYLFS--------GFIVARVP- 153 Tetrahymena thermop...
Q9HPA6   197 EAFGDQASM---------------------------MKEQFRPMVWIMLLTIPVFLWMYWKLGtg----tiPQSELNMV- 244 Halobacterium salin...
Q5UXG9   202 ELMTDQMGM---------------------------FKQQFRPMVWIMLVNIPLFLWLYWIVFg------aGVDASPVIt 248 Haloarcula marismortui
Q18GM3   210 DAMGDQLGM---------------------------FKEQFRPMVWIMFLTIPVFLWMYWSIGvgan-aeaQVSLSTLV- 260 Haloquadratum walsb...
CAI50547 201 EAMADNLGM---------------------------FKEQFRPMVWIMLLTIPVFLWMYAVVGfrgaplypEIELVPVV- 252
Q9HR70   204 DAAGDQLGL---------------------------FKLQFRPMVWIMLLTIPVFLWLRWEVRgg----hlGASEHGMV- 251 Halobacterium salin...
Q0W1W2   129 SMMEDQSQL---------------------------SKQQLKPMGFLMIISVPLFFWMYWFLT--------NNPDMTMV- 172 uncultured methanog...
A0B9U6   114 EMMGDQGKM---------------------------MKMQLKPMAYIGIVSVPLFMWAYLYID--------QHSI-TMV- 156 Methanothrix thermo...
Q8TRR7   119 EMMEDQMKM---------------------------SKQQFKPMAYISIISLPLFMWAYYFIS--------GHGNATMV- 162 Methanosarcina acet...
Q12ZS6   119 DMMGDQMEM---------------------------SKQQFKPMAYISIISLPLFMWAYHYIS--------GHPGASLE- 162 Methanococcoides bu...
Q23A34   154 FPLTQKFRQMLqsgmnmMNLNVRYVSSLSLYFLVLSSLSQLISIFLKNE 202 Tetrahymena thermophila SB210
Q9HPA6   245 LPLLGEID-LN------GGRVLVFPAWILWYMMCSFSFSNIIRKALNIQ 286 Halobacterium salinarum
Q5UXG9   249 LPIFGEVEAWS------NSVAGPVQAWIVWYFLCSLSFTQIIRKALNVE 291 Haloarcula marismortui
Q18GM3   261 LPLVGEVA-WT------DSVLGPIQAWIVWYFLCSMGFTQIIRKSLNID 302 Haloquadratum walsbyi DSM 16790
CAI50547 253 MPIAGEVD-WT------HGLLGPIQVWIVWYFVCSMCFTQVLRKALNIQ 294
Q9HR70   252 VPLAGHVA-WQ------HALLGPMATWIVWYFVCSMASRQFLQKTFNIQ 293 Halobacterium salinarum
Q0W1W2   173 FPFWGEQK-LL------DSAWFVFQYWIVWSFICSLAISQVIRKAINVG 214 uncultured methanogenic archaeon
A0B9U6   157 FPFWGEQN-IK------HIVWGPILYWFYWYFVCSIPISQIIRKALDIG 198 Methanothrix thermoacetophila PT
Q8TRR7   163 FPFWGEQL-LT------TPVFGPFQHWIYWYFISSLGVSQLIRKGLNIG 204 Methanosarcina acetivorans
Q12ZS6   163 FPFWGTQI-LV------ETVIGPIQYWIFWYFITSLAISQVVRKALNIG 204 Methanococcoides burtonii DSM 6242
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