4GIW,2DWG


Conserved Protein Domain Family
RUN

?
pfam02759: RUN 
RUN domain
This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.
Statistics
?
PSSM-Id: 397055
Aligned: 40 rows
Threshold Bit Score: 90.7886
Threshold Setting Gi: 402550730
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
4GIW_A     54 TLCPALHALVADGLKPfRk------------------------------------------------------------- 72   human
Q6NXD8   1163 GLVWALEQFFHHGFRs---------------------------------------------------------------- 1178 zebrafish
Q54LN3   1015 RLATAIANLVSHGFIVsPtnmvgsifrnvingat---------------------------------------------- 1048 Dictyostelium dis...
Q7QH55    369 RLAKTIQRLMQHGLRSiSesashslvpfisgcfsttgsghsgtnhssmsgranesfyrsevrrkstgatttapkkqssyv 448  Anopheles gambiae...
Q94222    607 RLANSFRQIMDHGIREnAlytsmay------------------------------------------------------- 631  Caenorhabditis el...
Q17FM5    615 TLAPTIKQVLEHGMKRpSflggpch------------------------------------------------------- 639  yellow fever mosq...
Q96C34    429 ELTVAVRDLLAHGLYAsSpgmslvmapiacllp----------------------------------------------- 461  human
Q9W5C1    516 NFARTLQQLIQHGLRIpAesaasslmvpfmrclhpgppvvp--------------------------------------- 556  fruit fly
Q17Q22    446 QLAKTIQGLMQHGLRGiTessgslvpfisgcfsgggyhsqgpsknsaeerfyrgdsrrkstggmtkaa------ttppkr 519  yellow fever mosq...
CAF87805   39 ELAPALKDLLAHGLFSpSqtmslvlapiscllp----------------------------------------------- 71   spotted green puf...
4GIW_A     73 --------------------------------------------D-LITGQRRSSPWSVVEAS----------------- 90   human
Q6NXD8   1179 ----------------------------------------------ARIFQKNVFVWDFFERIvafmenrdqtgdlqesp 1212 zebrafish
Q54LN3   1049 -----------------------------gsggggsgggnslssSlGNIVTGKRHLWEFIENY----------------- 1082 Dictyostelium dis...
Q7QH55    449 eedtsnaavteenlfsqldddeeedmepqfdsnnkdemhvwellLvYYNIKNGDRYNSTPARKlsesfn------ldivd 522  Anopheles gambiae...
Q94222    632 -------------------------------------hpwsfieD-IAYYSVEKNFNSVYSRLtlcntf------nlded 667  Caenorhabditis el...
Q17FM5    640 --------------------------------------pwlfieE-AATREVEKDFESVYSRLvlckty------rlded 674  yellow fever mosq...
Q96C34    462 -----------------------------afssapeamhpwelfVkYYHAKNGRAYVESPARKlsqsfa------lpvtg 506  human
Q9W5C1    557 ---------------------pavggdsqflglgramhawelvlA-YYRLKHGEEYNNTPARKlsqsfq------ldivd 608  fruit fly
Q17Q22    520 nsssleeeepiemnlftqleededeeveycdgdesemhawelllL-YYNIKNGDRYNSAPARKlsesfn------ldlve 592  yellow fever mosq...
CAF87805   72 -----------------------------hqpapqalhpwdlfvK-YYHSKNGRAFVESPARQlsqsfs-----lpvgga 116  spotted green puf...
4GIW_A     91 VKPGSSTRSLgtlYSQVSRLAPLSSS----------RSRFHAFILGLLNTKQLELWFSSLQEDAG---LLSLXYXPTGFF 157  human
Q6NXD8   1213 EPLSLNSESL---CRYVNAINNMPRNig-------kDGKFQLLVCLGARDRLLPQWLPLLAESP----VITRMYEENALL 1278 zebrafish
Q54LN3   1083 KKTTQHGTIAg--ISLIQTINTINSFenissawkdpNIKFRTLICVGLNQHVLDQWFALLQTDTN---GISHYFHPNAII 1157 Dictyostelium dis...
Q7QH55    523 GRPLSNKQSL---LSAIGSIIALHSPykr-----syDSQFKAFVCAGLNAQKLTQWLYLIFQCKE---LVSSHYASWSYV 591  Anopheles gambiae...
Q94222    668 GKILTPEELL---FRSVQLINDSHNAvsa-----hsDVKLRSLLVVGVNEQCIHLWFDLLCSATQhehIRNKYYHSWAFI 739  Caenorhabditis el...
Q17FM5    675 GKVLTPEELL---YRCVQAVNQSHDAaha-----qmDVKLRSLICLGLNEQVLHLWMEVLCSCSE---IVHKWYQPWSFI 743  yellow fever mosq...
Q96C34    507 GTVVTPKQSL---LTAIHMVLTEHDPfkr-----saDSELKALVCMALNEQRLVSWVNLICKSGS---LIEPHYQPWSYM 575  human
Q9W5C1    609 AQAVTAKQSL---LSAVGMILAMHRPykr-----snNAHFKAFVCAGLNSHLLVEWLNLILSCHE---LVDTYYSADSYV 677  fruit fly
Q17Q22    593 GRPQSNKQSL---LSAIGTIIALHSPykr-----syNSQFKAFICAALNAQKLTQWLHLIYQCKE---LVSSYYTSWSYV 661  yellow fever mosq...
CAF87805  117 AVTVTPKQSL---LWAIHSVLKEHGRykr-----gpDTKFKALVCMALNEQRLVSWLNLLCKSG----TLVDHYQAWSYM 184  spotted green puf...
4GIW_A    158 SLARGGcpslstEL-LLLLQPLSVLTFHLDL 187  human
Q6NXD8   1279 RDKLTVs-----SL-LGVLETLHDFPITLET 1303 zebrafish
Q54LN3   1158 NSLDHWr-----LF-CQCFAPILNLPFKLSL 1182 Dictyostelium discoideum AX4
Q7QH55    592 ANTGFR------DA-LKTLDCLTQYRFDLPV 615  Anopheles gambiae str. PEST
Q94222    740 RSPAWR------QI-KCDLRLLSQFSFNLSM 763  Caenorhabditis elegans
Q17FM5    744 YSPGWV------QI-KCELRLLSQFAFNLNP 767  yellow fever mosquito
Q96C34    576 AHTGFE------SA-LNLLSRLSSLKFSLPV 599  human
Q9W5C1    678 ARTGFR------DS-LRSIDALSRFDFDLPV 701  fruit fly
Q17Q22    662 ANTGFR------DA-LKTLDRLTQYRFDLPV 685  yellow fever mosquito
CAF87805  185 AQTGFE-------GaLRILGRTSHLKFSLPV 208  spotted green pufferfish
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap