5V86


Conserved Protein Domain Family
Cullin_binding

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pfam03556: Cullin_binding 
Cullin binding
This domain binds to cullins and to Rbx-1, components of an E3 ubiquitin ligase complex for neddylation. Neddylation is the process by which the C-terminal glycine of the ubiquitin-like protein Nedd8 is covalently linked to lysine residues in a protein through an isopeptide bond. The structure of this domain is composed entirely of alpha helices.
Statistics
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PSSM-Id: 397562
View PSSM: pfam03556
Aligned: 187 rows
Threshold Bit Score: 78.374
Threshold Setting Gi: 154336869
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5V86_A       262 LKAQIPKMEQELKEP-GrFKDFYQFTFNFAK---NPGQ--KG--LDLEMAIAYWNLVLn----------gRF-------- 315
EDQ52851      71 LQAKLlda--------rnFSVFYRFVFFMCR---DPGQ--KN--ISVSTAIAGWRLALtg----------rFr------- 118 Physcomitrella ...
KQK15075      63 LMSVLeldd------arhFSTFYDFVFFISR---ENGQ--KN--ITIQKAVAAWRIVLng----------rFr------- 112 stiff brome
VDC68396      72 LMSRLdlmas---vdfseFTRFYDFVFFMCR---ENGQ--KS--ITVAKAITAWKLVLag----------rFr------- 124 field mustard
XP_004232218  71 LRLNLead-------fseFSRFYDFVFFVFR---ENGQ--KN--ITISKAVTGWKIVLag----------rFr------- 119 tomato
XP_001564670 126 LRQKLGEWVKDVRESsGaFLLMYTYMYDYIR-----GEedRR--MTRTTAINGWDVFFgq-------------------n 179 Leishmania braz...
CAM71855     118 MRQNVTEWVKDVRESgGsFLLMYNYLYDYIR-----GEedRR--MTLTTALSAWDVFFsk-------------------n 171 Leishmania infa...
Q4Q0J0       119 ahdAIVDLNNTIRSNeEkRSKFYQFLYNWCLkgnDASD-------RVDSAKELWSCFFsaspvsltveeaRRkftayvcf 191 Leishmania major
Q4CTL1       117 MRSHVDEIDEVLHKDpDqFRKFYRFIFGWVRspeTTARslGElgMNIATAVELWQMLFpe----------yKt------f 180 Trypanosoma cruzi
Q38A65       116 LRNHVETLDGALRGDvTkFRHFYRFIYKWVQsplTMERnmGQvgMSIETAVELWRMLFph----------yRe------f 179 Trypanosoma brucei
5V86_A       316 KFLDLWNKF-LlehHKr--------------sIPKDTWNLLLDFS--Tmi-----aDDMSNYDEEGAWPVLIDDFVEF 371
EDQ52851     119 -LLDQWCAF-VqvhQRh--------------aVSEDTWRQVLEFSrsVh-------eDLSNYDVEGAWPVLVDEFVEN 173 Physcomitrella pa...
KQK15075     113 -LLDRWCNF-VekyQRh--------------nISEDAWQQLLAFSrcVn-------eDLEGYDPKGAWPVVIDDFVEH 167 stiff brome
VDC68396     125 -LLNRWCDF-TeknQRh--------------nISEDTWQQVLAFSrcVh-------eNLEGYDSEGAWPVLIDEFVEH 179 field mustard
XP_004232218 120 -LLDHWCDF-VekkQRy--------------nISEDTWQQVLAFSraVh-------eNLEGYDREGAWPVLIDDFVEH 174 tomato
XP_001564670 180 kRYAKWKTWaVanlTGd---------------VSRDLWRQLGIFLtmDtdatqssdDQVLAL----SWPSAIADFIEt 238 Leishmania brazil...
CAM71855     172 dLYAKWKAWaVanvKGg---------------VSRDLWRQLGIFFtmDttaaqrfgDQISAL----PWPSAIADFLdq 230 Leishmania infant...
Q4Q0J0       192 PRINQWLDF-ItmlGEkatesksgrvaveqsgVSFDTWTQLLLFAr---------fDNYDAYDDEDSWPVTMDDFVVY 259 Leishmania major
Q4CTL1       181 LKMNDWITF-CttkEIfhr-----------eaISRDLWEQLLEFTslT---------RYDTYDVNDAWPSAIDDFVEY 237 Trypanosoma cruzi
Q38A65       180 KRLDDWITFcMskkLFph------------giISRDLWEQLLEFTfvT---------DYSKYDVSDAWPSAMDDFVEY 236 Trypanosoma brucei
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