6VJA


Conserved Protein Domain Family
CD20

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pfam04103: CD20 
CD20-like family
This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.
Statistics
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PSSM-Id: 397979
View PSSM: pfam04103
Aligned: 41 rows
Threshold Bit Score: 48.4049
Threshold Setting Gi: 75045739
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6VJA_C        14 TLGAV---QIMNGLFHIALGGLLMIPAGIyapICVTVWYPLWGGIMYIISGSLL-AATEKNSR----KCLVKGKMIMNSL 85 
Q3TRE0        28 lLALL---QLALGIAVTVLGFLMASISPS----LLVRDTPFWAGIIVCVVAYLG-LFMLCVSYq--vDERTCVQFSMKVF 97  house mouse
Q1LVQ8        42 LVALL---QLLLGIAVAAVAFLMLAISSS----LLARETPHWAGIIMCVVSLLG-FVLFCITRvpdeR--ALLQFVIKLL 111 zebrafish
Q5HZJ5        36 TLGLA---QVLLGILVITFSMVASSVTTT---ESIKRSCPSWAGFSLAFSGLVG-IVSWKRPF----TLVISFFSLLSVL 104 house mouse
Q0V9M1        36 SLGVS---QMVLGCLIVAVSFAALALTTS---ARVRHSCPFWAGFSVLLSGLIG-VVAWKRPL----SLVITFFMLLSAV 104 tropical clawed...
Q95PZ5        94 RLCLV---ELMLAVVILGGGIWCYRDTSD----YCPYYSAIWTSAIYIINAIVG-SAAAKMGA----LNLYMAHLTLSLV 161 Caenorhabditis ...
EDO34181       7 LLGIIssfHLVFGVFSVVLGIVTFKVAPY---FYGVFGMGIWLGAWMLITGVAGlLTASVPTN----MCRLGSFIGCSLV 79  starlet sea ane...
NP_001037935   3 VLGIL---QIACAGISIVSGFMDGAFRREs--TLGRTRAPLWAGLIMTIPGVLA-LFSSQKKN----PVLVNALIAASVF 72  tropical clawed...
XP_002935642  85 SLGLL---QLILGCCTVALSFGALSLSKS---PQIRSSCPFWAGSSVILSGIVG-LTTWKRPM----VLLVNLFVMLSVV 153 tropical clawed...
CAG03430      34 vVALL---QLLLGVAVTVVAFLMLAISPS----LLARETPHWAGIILCLVSVLG-FILYCITYl--pDERTSAQFICEVL 103 spotted green p...
6VJA_C        86 SLFAAISGMILSIMDILNIKISHFLkmeslnfirahtp--yiniyncepanpSEKNSPSTQYCYSIqslFLGILSVMLIF 163
Q3TRE0        98 YFLLSALGLMVCMLAVAFAAHHYSLlaqftcets----------ldscqcklPSSEPLSRAFVYRDvtdCTSVTGTFKLF 167 house mouse
Q1LVQ8       112 YFFLCTMGLVMSVVVIAFQCYHYTLtnsfscrem----------redcictlDPEDPIARMFVFSAvsdCSDITSTLPMY 181 zebrafish
Q5HZJ5       105 CVMLSMAGSVLSCKNAQLARDFRECsmegkvcvccpp----iplhrpcpewgQELKVALNSTCDEArgaLKNLLFSVCGL 180 house mouse
Q0V9M1       105 CVMLNLAGSILSCQNAQLVSSLEGCqlinfnsdgvcvccemqhqtsgcsnpgETLKLNPLQECSAVrltLKDLLFSVCAL 184 tropical clawed...
Q95PZ5       162 SVMMCLISGGLSARNWALVGTYHHPridrdeafcllg----thdtsrisyifSHMDKYDFAKCLWQlkvGVAVNSVQFVI 237 Caenorhabditis ...
EDO34181      80 GLVTLFVCAIIIGLGVLQHFKFESSinreyyia-----------kgpnyhkeYSRPQEHFDERNQNgenGVGIYGTLLAL 148 starlet sea ane...
NP_001037935  73 SCFTTLIVIVYASLTLGYGEDDDDIfs------------------------sPPHVIHARFILGKL---VQGANIAMLIA 125 tropical clawed...
XP_002935642 154 CVLLNLAGFILGCQGAQFVSSVPSCqlvemnegkvcvc-ceeiyankclereNFLKLFPVQSCNAVhllLKKVFFALCAL 232 tropical clawed...
CAG03430     104 YFILCSIGLVLSVLVVAFAGHHYSQasgfscgpa----------rgdcvctlSQEDPIARTFTYEGvgdCQAITGTLTLY 173 spotted green p...
6VJA_C       164 AFFQELVIAGIVENEW 179
Q3TRE0       168 LIIQMVLNLVCGLVCl 183 house mouse
Q1LVQ8       182 YLLQVLLNLAQAIVCL 197 zebrafish
Q5HZJ5       181 TICAAIICTLSAIVCC 196 house mouse
Q0V9M1       185 NIISTIVCALATAMCC 200 tropical clawed frog
Q95PZ5       238 AAIEVFLNILSAILCM 253 Caenorhabditis elegans
EDO34181     149 IVMDVIVNLVTMAVCK 164 starlet sea anemone
NP_001037935 126 SVSSLCVALCIAYMGC 141 tropical clawed frog
XP_002935642 233 NALTTTVCLVAAALRy 248 tropical clawed frog
CAG03430     174 FLVQIVLNLAQALVCa 189 spotted green pufferfish
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