Conserved Protein Domain Family
Phospholip_B

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pfam04916: Phospholip_B 
Phospholipase B
Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester bonds of glycerophospholipids. This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast. In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina.
Statistics
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PSSM-Id: 398535
View PSSM: pfam04916
Aligned: 17 rows
Threshold Bit Score: 543.495
Threshold Setting Gi: 568251377
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q54ZI6         6 LLIVIVFLISNSYSLSSSDS------------SSDSGSDVqyysltsqfqvvqgKQI--------PGSI-------AWGY 58  Dictyostelium d...
EGD78150      13 LLLAVVVGYSSGQAAASPSK------------TAVACARKgqdgfd---crvvsASG--------GEWT-------ALAS 62  Salpingoeca ros...
Q57ZQ0        17 LLLAATLTLSTPVAVRGEVLkda------tptVVTVWYNAtsggfyatdglasgKYA-------------------AIVN 71  Trypanosoma brucei
Q9XWV2         6 IFLAAAVAIGCEARQERTYTvcqk-----pegDLHYf-----------------KEGrktdeelcAKRL-------ATAY 56  Caenorhabditis ...
EFX77541      11 VSLQLICIQSVQVSQAPESKtafavfdesneeFVIVHHEPprd------------------------------kyvAGAQ 60  common water flea
O62146        39 LLLATVVASQSS--------------------------EGrdesytykqlcivdDKPqvldgfdcRNQV-------AVAR 85  Caenorhabditis ...
Q9BL07         6 FLFGLIFAVEQEKPYLDNNrvp--------veQILNDHSSakfdytyvsvcvnsTDEtlld-ivyAKECknaasrvALGK 76  Caenorhabditis ...
EFA85087      12 STLLMVTVFSQDYPTVSVDKnvf------lqsSVSVNVIFyqnsytlqlassaiPSG--------GVVV-------ASGT 70  Heterostelium a...
XP_004347450  14 ATAAAALAVACSWQSQGVSAagf------nytEATVYYNAaqdaftltvgvldlKNG--------I----------VAAT 69  Capsaspora owcz...
EFA78500       6 NILVLIVAFASLSSSIDVSRqq---------rQHTVNAPSnlqtft---alldlNNGfrvvsgnqSNGV-------AWCL 66  Heterostelium a...
Q54ZI6        59 FK-DEMNKDGW---------GKLSIET---VSTVSDNIAFKAAGYLEGYLTWEYIYKFSGNYFNSffntsnikEIPteTL 125 Dictyostelium d...
EGD78150      63 HNlPAYNMTGF---------AKLHVQTkpsTSVQNDNLAAFSAGYVEGLVTADMIYNTYLNLEPE--------HDPk-VM 124 Salpingoeca ros...
Q57ZQ0        72 VS-NTFNKTGWdvvtavandGFMHLPGeaePSAERVLLAYKAVGFGEGYATYESMKASINNTFEGpeglsallSDApqAQ 150 Trypanosoma brucei
Q9XWV2        57 FH-DEVNQTGW---------AFLEVDVi--SPKIPHYLQGYAAGFAEGRATRHLIDLHIINTVNGycdgakhfCDE--LG 122 Caenorhabditis ...
EFX77541      61 FT-NAINQTGW---------ANFEVWT---NGNFPDSVQSKAAGFLEGYLTHELIYFSYLNTLQDyckgrdgyCSK--LR 125 common water flea
O62146        86 WQ-NAVNTTGW---------TFLEVET---KENYCPQLQAYSAGYLEGLLSKTVLTYHLKNAQEDycknftgyCSR--LS 150 Caenorhabditis ...
Q9BL07        77 YS-NQVNTTGW---------GILEIET---FASHSYDVQAYGAGVAEGELTRLQIYYHYRNTIETmcnnhtlfCKR--LY 141 Caenorhabditis ...
EFA85087      71 YI-DDIPNNGW---------GNLTITT---LPYISDLNQAYIGGFIEGVITAERIYQMWTNYAANefv--nstPSSt-LI 134 Heterostelium a...
XP_004347450  70 FN-DSMNIDGW---------GTLRIEQt-dRLVNHDSLKAFGTGFIEGALTADRIWQAHVNLNARwgfndtagYPPy-LI 137 Capsaspora owcz...
EFA78500      67 YG-NEMMTTGW---------GYISIQT---NGAYNDTQQASAAGYLEGYVSAEMIYQNWYNMYVNeyk---ksVNDk-AI 129 Heterostelium a...
Q54ZI6       126 TFVSDNWEYMMERVNSSSTtDP-------------YWIQIRNAMSQQIGLYEGYNa-aAGEDYQ--K--TFIEIYMINLY 187 Dictyostelium d...
EGD78150     125 AFVQQNYNWTMDKIKHNPQ-DP-------------FWTQVALVYQQLNGLVAGYN---AAGQKK--L--TFTDMLLLNLL 183 Salpingoeca ros...
Q57ZQ0       151 HWIEEHVRYMDAAKFESSA----------------FYTQLRNMLALIDGMVAGYNa-rAPADER--L--DRMKLLMYNMQ 209 Trypanosoma brucei
Q9XWV2       123 EFMVDNLKWMEQEIRENPE-DE-------------YWQQVNLTVNQLFGLIHGYEnqlGAEIDFkqI--AVHPIFMIQIA 186 Caenorhabditis ...
EFX77541     126 TFLATNTKWVNKMYTKLRNtSP-------------FWHQVGLFYEQMEGLAAGWe--kAAVNTGhsM--GTYGFMWFNIF 188 common water flea
O62146       151 DFLTENQKWIQSSLETVAPdDL-------------YWGAVNRTYHQVSGLIDAY----EGREFKprItyELHPILYLNLN 213 Caenorhabditis ...
Q9BL07       142 IYLQQNLDWMRSQVQANPPtDP-------------FWRQVNLTFAQLTGIYDAY----SKRNLTpeIgfDLHPIYMMQLA 204 Caenorhabditis ...
EFA85087     135 SYMSSQLQWVRQSISEPHDdNPypmneegtinatvYWHTAGLLMGQFDGMVAGY----AAVPAMvpI--TAMQLYLLSSA 208 Heterostelium a...
XP_004347450 138 EFFEEQYGFMRNSTQQNAT-DP-------------YWQYLSLLMDQFDGLGHGYNm-yADSDKR--L--TPLQLYIMNSA 198 Capsaspora owcz...
EFA78500     130 AWIDSNNRYMQQQVAENLD-DP-------------YWQQVGLVMTQVASLFQGYNd--ATTDPSqsL--EFYDILLMNMD 191 Heterostelium a...
Q54ZI6       188 GDMGDIVtltttpnnef-----------ipmdrkeveQLMA--------TTGHCTSIIKLTNNCSDLMSAHTSWADFSVM 248 Dictyostelium d...
EGD78150     184 VDLPTIElalypgkrpn----------vtamtqqelkDFMA--------DTTHCSAMVKVTDDLSDLMFTHTTWCPYSQM 245 Salpingoeca ros...
Q57ZQ0       210 AEIGDIVratspaevld----------------------dmrqmmprwfVDTHCSAFVKVVK--DDIYFGHATWSSFNTM 265 Trypanosoma brucei
Q9XWV2       187 GDLEDLAmkfkk--------------------penpkKVFS--------GPGHCSALVKLLPKNEDILFSHVTWSSYGTM 238 Caenorhabditis ...
EFX77541     189 GDMEEFEqmfap---------------------qkagKDWRlnkvgrrhMFASCSALIKVLPDASDIYTSHVTWNGYESM 247 common water flea
O62146       214 GDFYDLEkk-----------------------------lNKtrdpafeqTGGKCSGLIKVAPGNADLFISQVTMSGFQNM 264 Caenorhabditis ...
Q9BL07       205 GDMFDLNkl-----------------------------lNKtadpmeypEGGRCSGFVKLAPGNKDMFMAHVSMSSLSWM 255 Caenorhabditis ...
EFA85087     209 GDLQTLnslygnpgvnakv--------spflwgndkgadAI--------DFLDCSALVRIIPNSQDVYFGHTTWRYYYGM 272 Heterostelium a...
XP_004347450 199 GDMEDLVggllvkqglpyylgmtrdrmvavgmdpdnpqppaedafpwdkiMQDCSVLIKVLPGFEELLMAHATWRDFGQL 278 Capsaspora owcz...
EFA78500     192 GDMIDLApalnisfdaat--------aaalppkqhleNFMR--------KTGHCSSLIKLTDDLTELYAGHTTWSSFYEM 255 Heterostelium a...
Q54ZI6       249 IRIYKRINIP-----VASTPY--GSETLFSSYPGLLVSIDDFYqIRPSKLHLTETLNTILNQTLY--QQINAQ-SFMYWV 318 Dictyostelium d...
EGD78150     246 LRIFKVYHLP-----YSTTAGtkTSTVMFSGYPALLESLDDYY-ITSERMAIMETTNGIFNNTLY--DMVNPS-TLPYWV 316 Salpingoeca ros...
Q57ZQ0       266 LRQYKTYAFG-------------GRFVTMSSYPGLAHSVDDWY-MTHKRLAVMETTNVIHNATLL--RNHVGSsSVATFL 329 Trypanosoma brucei
Q9XWV2       239 LRINKKYSFK---------TGdpGQIYSFSSYPASITSTDDFV-LTSAKLAILETTIGNYNEKSL--DLITPN-TVLTWI 305 Caenorhabditis ...
EFX77541     248 IRILKKYNFEvhrtaAEDSAVipGHSMSFSSYPGLLYSGDDFS-VISSGLVSMETTIGNNNVELF--KYIKPTgQVLEGV 324 common water flea
O62146       265 LRVIKLYKFG------YDRQFypGYASSFSSYPGLLYSSDDFA-LQTSGLAVIETTISVFNTSLF--ENTKPVgQLPTWI 335 Caenorhabditis ...
Q9BL07       256 QRVLKIYKFG------YDVNEvpGHIVTFSGYPGVLISTDDYT-ITSAGLTSIETTIAIFNQTLYtdKFMKPEgQVHCWI 328 Caenorhabditis ...
EFA85087     273 MRIFKTYQFE-----FQEYGn--PYVAAFSSSPGFLSSKDDFY-VTGHQLAVMETTNEIFNDTLY--SFVIPE-SFLVWQ 341 Heterostelium a...
XP_004347450 279 IRLYKFYDFT-----YDMAGLq-STTLSFSSSPSFLSSKDDFY-VLDSGMVVMETTNSILDQTLY--QKLSPQ-TVLCWQ 348 Capsaspora owcz...
EFA78500     256 VRMFKIYTFA-----FSSSSLsrSATTMFSSYPASLSSIDDFY-LLDTGLVVVETTNGMMNNNLY--YLVTPS-SVLSWI 326 Heterostelium a...
Q54ZI6       319 RNLVANRLANNG-FQWVSIFVEnNSGTNNIQFVVLDYKLFTPyST--ELQS-DLLWIVEQYPGG-----YQAADVTLTLw 389 Dictyostelium d...
EGD78150     317 RVIVATRMTNTG-REWHERFYQyQSGTYNNQWMTIDYKLFVP-GQ--PLPH-GIFWVSEQIPGA-----YVLEDKTMDL- 385 Salpingoeca ros...
Q57ZQ0       330 RAMIANFIAVDA-PSWVSNFSReSSGAYNNQWMVLNMGAVESeAMfkNMAP-NTFWVLEQLPGTapplgITSKDMTSVLn 407 Trypanosoma brucei
Q9XWV2       306 RAEIAHRTASSG-LQWAEAFGRhNSGTYNNEWVVVDYKQFHRgKE--VQPEtGIIHVVEQMPGH-----IVHSDKTAHLf 377 Caenorhabditis ...
EFX77541     325 RSMVANRLASSGiKKWTEVFSRhNSGTYNNQWMIVDYKLFKP-FK--PLRD-GLFWVLEQLPTL-----IESRDATDVLr 395 common water flea
O62146       336 RAIVSNQLARDA-REWCKLYSLyNSGTYNNQWAVLDYKKFKP-NQ--PLPKnGLFYVLEQMPGK-----IVYSDLTWFVe 406 Caenorhabditis ...
Q9BL07       329 RSMISNLLSRTG-KQWVDMFGRyNSGTYNNQWTVLDWKQFTP-EK--ELPDkDVLWISEQTPGY-----YETRDMTWYLk 399 Caenorhabditis ...
EFA85087     342 RAVVSNILATNA-QSWVQVFQQyNSGTYNNQWMVFDYKLFKS-GS--TLPP-NTFWILEQIPGY-----CELADVTPELn 411 Heterostelium a...
XP_004347450 349 RVMASNALAGTP-QHWTEIFARyNSGTYNNQWQVVQMGNFEQ-FF--ELPP-GTFWIIEQIPGT-----TAAQDVTGFLn 418 Capsaspora owcz...
EFA78500     327 RVIIANRMASNG-ANWCTTFGReNSGTYNNQWIIVDYNKFES-GV--DAHD-GMVYVLEQIPGY-----VEYDDVTNIV- 395 Heterostelium a...
Q54ZI6       390 EQGYWPSYNRPYFEEVFDILGYPYYVEkfgdlftyEYNPRANIFRRDHSKLETLQDMMNIIDYNQYktdpfsmg------ 463 Dictyostelium d...
EGD78150     386 QRSYWPSYNVPYYPWIYNVSNYPAAARahgddytyQLAPRAKIFRRDAGAVESVDDLKTFIRMNHFeqhdplap------ 459 Salpingoeca ros...
Q57ZQ0       408 TTGYWASYNRPYFPNVYNLSGTLKMQEeygdfysyKNYSRARIFERDQGSVVDIESMKRLMRYNNYtkdpfslipnctga 487 Trypanosoma brucei
Q9XWV2       378 RETYWPGYNQPYYKQIIRFSDTDKMVEkfgdwysyDKTPRALIFKRDHNTVTDMSSMIALMRSNNYtkdplskcdcn--- 454 Caenorhabditis ...
EFX77541     396 SQSFWPSYNSPYFPTIFNLSGVPALVEeygdwftyDKTPRALIFNRDQSKITDMDSMIRMMRYNDYrndplsrcekce-- 473 common water flea
O62146       407 KYSYFPSYNIPFFKEITEISGFIGQAAkmgdwfkwGASPRAKIFERDHGNVHDLDSLTALMRYNDYkndefskckcn--- 483 Caenorhabditis ...
Q9BL07       400 KYTYFASYNIPFLPKVSEISGFDNKARqfaw-fdwGGSPRARIFDRDHSKVTDIDSLTKLMRYNDYtheefarckctp-- 476 Caenorhabditis ...
EFA85087     412 KNGFWPSYNIPYFPYIYNISGYNEQLAkygnsysyEQCPRAQIFNRNSSSINTYEQFQAMMQFNNYvsdplsqg------ 485 Heterostelium a...
XP_004347450 419 QNGYWPSYNIPYSPMIYNLSGYPAYFAkygnqfsyTENPRATIFRRDHNNVVDLESMQTIMRYNEYqtdplslg------ 492 Capsaspora owcz...
EFA78500     396 RTGYWPSYNVPYFEYIYNVSGFNNT-QsygnffsySGNPRAMIFRRDANNVYTFEQYQAELRYNNWehdplsag------ 468 Heterostelium a...
Q54ZI6       464 -----------------ypgnsinaRFDIKggslPsgnpiys-----wfyhgtHGGIDGKAINYDMV----NSFTAVARN 517 Dictyostelium d...
EGD78150     460 -----------------tadsaiaaRRDLD----Ptap-------------raDGAIDAKIVNAAMV----LDMSVTAIA 501 Salpingoeca ros...
Q57ZQ0       488 vgmdddgnvtnvckppysamlsiaaRGDLN----PpgnateygplvrsvghvnSGAIDAKIATWTGMvknpESYTAHVVC 563 Trypanosoma brucei
Q9XWV2       455 --------------ppysaenaiacRSDLN----Plngtypf----kslgfrdHGAIDVKVTNSKLI----NSLQFTAVS 508 Caenorhabditis ...
EFX77541     474 --------------pkysgenaisaRNDLN----Pangtypf----halshrsHGATDCKVTSHQLM----TSLDFIAVG 527 common water flea
O62146       484 --------------ppysaeagisaRGDLN----Pangtyef----pgqghvnHGALDYKGTNVELM----KKLQFVAQG 537 Caenorhabditis ...
Q9BL07       477 --------------npytgeggisaRGDLN----Tpggtyev----esmgfrdHAGLDFKGTNYEMF----KKMRFRAWG 530 Caenorhabditis ...
EFA85087     486 -----------------spmnaissRADLL----Atgk------------qkaFGGVDSKITSSKQI----PTLGATCIS 528 Heterostelium a...
XP_004347450 493 -----------------dpanaiasRYDLR----Psgg-------------saFGAIDGKITSVELAl---EYLGCIAIN 535 Capsaspora owcz...
EFA78500     469 -----------------nsgnaissRFDLV----Tksdpnnp-----ylnkdaFGGIDSKAVNHAMV----RNMQVAAQS 518 Heterostelium a...
Q54ZI6       518 GPTVT-SDc-PPF----NWND---WSLiSHQYMPQIYNFTW 549 Dictyostelium discoideum
EGD78150     502 GPTHD-TQ--PVFswtgMWAN---ETRgKHYGHAQRFGFDW 536 Salpingoeca rosetta
Q57ZQ0       564 GPTTD-NQ--PPF----QWVDgmfDPMpPTYGLLKLYNFSF 597 Trypanosoma brucei
Q9XWV2       509 GPPGGvTKdvPIF----DWKTsplREKvPHFGQPDRWNFAP 545 Caenorhabditis elegans
EFX77541     528 GPTFD-SL--PAF----RWSEsdfVNL-SHIGHPDLWKFEP 560 common water flea
O62146       538 GPTWG-KV--PSF----KWSEfdfKDKvNHVGHPDEWKFNT 571 Caenorhabditis elegans
Q9BL07       531 GPPYD-PL--PVF----DWNHtnlTNV-RHFGQPDVWNFTY 563 Caenorhabditis elegans
EFA85087     529 GPTHQ-GL--PPF----RFSAnpvLNAtSHIGLPDLWDFDW 562 Heterostelium album PN500
XP_004347450 536 GPTAQ-TQ--PPF----SWSTspfAANtTHLGHPDTFDFPW 569 Capsaspora owczarzaki ATCC 30864
EFA78500     519 GPTYD-QQ--PPF----NWKQgd--wTyTHVGMPEIWQFPW 550 Heterostelium album PN500
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