4ZDO,2E7J


Conserved Protein Domain Family
SepSecS

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pfam05889: SepSecS 
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O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS
Early annotation suggested this family, SepSecS, of several eukaryotic and archaeal proteins, was involved in antigen-antibodies responses in the liver and pancreas. Structural studies show that the family is O-phosphoseryl-tRNA(Sec) selenium transferase, an enzyme involved in the synthesis of the amino acid selenocysteine (Sec). Sec is the only amino acid whose biosynthesis occurs on its cognate transfer RNA (tRNA). SepSecS catalyzes the final step in the formation of the amino acid. The early observation that autoantibodies isolated from patients with type I autoimmune hepatitis targeted a ribonucleoprotein complex containing tRNASec led to the identification and characterization of the archaeal and the human SepSecS. SepSecS forms its own branch in the family of fold-type I pyridoxal phosphate (PLP) enzymes that goes back to the last universal common ancestor which explains why the archaeal sequences spcS and MK0229 are annotated as being pyridoxal phosphate-dependent enzymes.
Statistics
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PSSM-Id: 399111
Aligned: 5 rows
Threshold Bit Score: 396.19
Threshold Setting Gi: 152149023
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4ZDO_A  61 MDSNNFLG--NCGVgeregrvASALVARRHYRFIHGigrsgdisavQ-PKAAGSSLlNKITNslvldiiklaGVHTVAnc 137 human
2E7J_B  33 GDGYSVCDfcTTGR-------LDEIKTPPIHDFIHN----------QlPKFLGCDV-ARVTN----------GAREAK-- 82  Archaeoglobus fulgidus
Q18953  53 HDTNNRVDmiPVGAgeregrvLTPLVQRLHSNLTHGigrsgnlleiQ-PKALGSSMlACLSNefakhalhllGLHAVKsc 131 Caenorhabditis elegans
Q58027  57 MDTDKDPN--VVQIgerearvYTKLQRDGVFDFCHGvgrsgnlidpQ-PKAPGASVmYKLTNkllesflkalGLK--Vna 131 Methanocaldococcus ja...
Q8TXK0  53 MDTDKDPK--AARIgerearvASRLAEESVFGFCHGvgrsgtlvdpQ-PKAPGASImYALTNrlvtdflrrlGFR-IEga 128 Methanopyrus kandleri...
4ZDO_A 138 FVVpmatgmsltlcfltlrhKRPKAKYIIWPRIDQK---SCFKSMITAGFEPVVIENVLEGDELRTDLKAVEAKV-QELG 213 human
2E7J_B  83 FAV-----------------MHSLAKKDAWVVMDENchySSYVAAERAGLNIALVPKTDYPDYAITPENFAQTIEeTKKR 145 Archaeoglobus fulgidus
Q18953 132 IVVplctgmslslcmtswrrRRPKAKYVVWLRIDQK---SSLKSIYHAGFEPIIVEPIRDRDSLITDVETVNRII-EQRG 207 Caenorhabditis elegans
Q58027 132 IATpvatgmsl-alclsaarKKYNSNVVIYPYAAHK---SPIKATSFIGMRMRLVETVLDGDIVKVEVSDIEDAIrKEIN 207 Methanocaldococcus ja...
Q8TXK0 129 FVVpgatglsi----alclsalgEGEEVIYPYAAHK---SPIKAVRLAGFGMRVVDTEIEGDRIVVDPGDVEEAL-ER-- 198 Methanopyrus kandleri...
4ZDO_A 214 PDCILCIHSTTSCFAPRVPDrLEELAVICANYDIPHIVNNAYGVqsskcmhliqqgarvGRIDAFVQSLDKNFMVPVGGA 293 human
2E7J_B 146 GEVVLALITYPDGNYGNLPD-VKKIAKVCSEYDVPLLVNGAYAI---------------GRMPVSLKEIGADFIVGSGHK 209 Archaeoglobus fulgidus
Q18953 208 EE-ILCVMTTTSCFAPRSPDnVEAISAICAAHDVPHLVNNAYGLqseetirkiaaahecGRVDAVVQSLDKNFQVPVGGA 286 Caenorhabditis elegans
Q58027 208 ENNNPVVLSTLTFFPPRKSDdIKEIAKICQDYDIPHIINGAYAIqnfyyiek-lkkalkyRIDAVVSSSDKNLFTPIGGG 286 Methanocaldococcus ja...
Q8TXK0 199 SESPAAVLSTLTFFPPRSSDpLPEIAELCEEYGVPHVVNAAYGIqheqyrdllnraikrGRVDVVVSSTDKNLLTPVGGG 278 Methanopyrus kandleri...
4ZDO_A 294 IIAGFNDSFIQEISKMYPGRASASPSLDVLISLLSLGSNGYKKLLKERKEMFSYLSNQIKKLSEAYN------------- 360 human
2E7J_B 210 SMAASGPIGVMGMKEEWAEIVLRRSEKYKNKEVELLGCTARGATIITLMASFPHVRERIKRWDEEVEkarrfaaemeklg 289 Archaeoglobus fulgidus
Q18953 287 VIAAFKQNHIQSIAQSYPGRASSVPSRDLVLTLLYQGQSAFLEPFGKQKQMFLKMRRKLISFAENIG------------- 353 Caenorhabditis elegans
Q58027 287 IIYTKDESFLKEISLTYPGRASANPIVNILISLLAIGTKDYLNLMKEQKECKKLLNELLEDLAKKKG------------- 353 Methanocaldococcus ja...
Q8TXK0 279 IVYAPDEETLREVSRAYPGRASAAPVAHALISLLSLGMKGYRRLMRRQKECKALLDELLEDLEARRD------------- 345 Methanopyrus kandleri...
4ZDO_A 361 -ERLLHTPHNPISLAMTLKTLDEHRD---KAVTQLGSMLFTRQVSGARvvp-lgSMQTvsgytfrgfmshtnnypcAYLN 435 human
2E7J_B 290 iKQLGDNPHNHDLMFFHAEVLYEISKkakGGRFFLYRELKSRKIHGIK------PGLT------------------RYFK 345 Archaeoglobus fulgidus
Q18953 354 -ECVYEVPENEISSAMTLSTIPPAKQ------TLFGSILFAKGITGARvvtssqSKTTiegcefinfgshtteqhgGYLN 426 Caenorhabditis elegans
Q58027 354 -EKVLNV-ENPISSCITTK----------KDPLDVAGKLYNLRVTGPRgvrrndKFGTcylk----------eypyDYIV 411 Methanocaldococcus ja...
Q8TXK0 346 -DVRVLDVDNPIASAVAVEGHDP---------VDLAARLYVRRVTGPRgvraddPFGTsrlr----------gyhsNYIT 405 Methanopyrus kandleri...
4ZDO_A 436 AaSAIGMKMQDVDLFIKRLDRCLK 459 human
2E7J_B 346 L-STYGLSDEEVDYVLNAFKEIIE 368 Archaeoglobus fulgidus
Q18953 427 IaCSVGMTDHELEELFTRLTSSYA 450 Caenorhabditis elegans
Q58027 412 VnSAIGVKKEDIYKVIEKLDEVL- 434 Methanocaldococcus jannaschii DSM 2661
Q8TXK0 406 InAAIGVREEDVKTAVERLERELE 429 Methanopyrus kandleri AV19
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