pfam10409: PTEN_C2 (this model, PSSM-Id:402161 is obsolete and has been replaced by 463081)
C2 domain of PTEN tumor-suppressor protein
This is the C2 domain-like domain, in greek key form, of the PTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding. This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc (pfam00782) suggesting that the C2 domain productively positions the catalytic part of the protein onto the membrane.
Jiyao W et al.(2023). "The conserved domain database in 2023.",