Conserved Protein Domain Family
BAF250_C
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pfam12031: BAF250_C (this model, PSSM-Id:403301 is obsolete and has been replaced by 463439)
SWI/SNF-like complex subunit BAF250/Osa
This entry represents the mammalian BAF250a/b and its homolog osa from fruit flies. They are part of the SWI/SNF-like ATP-dependent chromatin remodelling complex that regulates gene expression through regulating nucleosome remodelling. In humans there are two BAF250 isoforms, BAF250a/ARID1a and BAF250b/ARID1b. BAF250a/b may be E3 ubiquitin ligases that target histone H2B.
Links
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Statistics
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PSSM-Id: 403301
Aligned: 18 rows
Threshold Bit Score: 336.982
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EDO30702      286 AISRRCICVSNILRGLSFVPGNDIEMHRHAGLLLILGRLLLLYHEHAHRVP-------YKRTYlqvDEEpdv-------- 350  starlet sea a...
3_pfamImport    1 DLAQRALALSNILRGFSFVPGSDLMMAKNEALLYIIGRFLRLNVTERKISSkrpvvvlDAEEL---KKEikkvsadekkv 77  
XP_011680406 2343 SFGQRCVCVSNIIRSLSFIPGNDQEMAKHPGLITVLSRILLLHHSHPRRKE-------LPQTY---DRD----------- 2401 purple sea ur...
EKC20059     2247 ELGRRCVCISNIFRSLSSIPSNHLELSKHPGLMYTLGKLLMLNHRHLPRNT-------TRRKF---DRD----------- 2305 Pacific oyster
EFX70974     1490 ALARRALALSNIFRSLSFVPSNETELAKNSTLLVIVGKILLLHHDHPLRSS-------HQKNY---DRE----------- 1548 common water ...
EDX15823      227 SLARRCIALSNIFRNLTFVPGNETVLAKSTRFLAVLGRLLLLNHEHLRRTP-------KTRNY---DRE----------- 285  Drosophila si...
EFA11411     1628 NIGKRCVCISNILRSLTFIPGNESEFSRSSTFLAIVGKLLLLHHEHPPRTQ-------KTRNY---DRE----------- 1686 red flour beetle
XP_001946583 1720 SIGKRCVCISNILRNLSFVPGNELEFAKSGPFLGLVGKLLLTHHEHPLRSS-------KTRNY---DKA----------- 1778 pea aphid
EGT37977     1278 ELSHRALALSNILRGFSFVPGSDALMARNEALLFIIGRFMRLNVIERKISSkrpgvvlDSEEL---KKEpkpltagekqa 1354 Caenorhabditi...
XP_003112070 1236 DLAHRALALSNILRGFSFVPGSDHLMAKNEALLFIIGRFMRLNVNERKISTkrpgavlNLEEL---KKDpksltedekra 1312 Caenorhabditi...

EDO30702      351 pvDD---------------------RDDWWWHCLEVLRENALVILSNIAGQLDLTFYSDTIRASVLEGLLHWLVCESADA 409  starlet sea a...
3_pfamImport   78 rdKAvldd--------------vdaTATQMIDTTNQLRDDAFVMLTHMSVSLNIYDLPDSIAFPIYDGLLRWAVSRVPEA 143 
XP_011680406 2402 --DQedldle----------cpitnSHRWWSDYLECMRENALVTITNLGGVLDMSKYVESVTLPMLDGLLHWAVCVSACA 2469 purple sea ur...
EKC20059     2306 --DSeledisd--------ghltqcDEEWWWEYFSMLRENTLVIFANICGHLELKYYPEEICMPILDGLLHWAVCPSSCA 2375 Pacific oyster
EFX70974     1549 --EDvdfasvdslg--asgsasskcETDWWWDTLLALRENVLVLMANIAGQLDLSIYSEEIVRPVIDGLLHWAICPSAQS 1624 common water ...
EDX15823      286 --EDtdfsds---------csslqgEREWWWDYLITIRENMLVAMANIAGHLELSRYDELIARPLIDGLLHWAVCPSAHG 354  Drosophila si...
EFA11411     1687 --EDadfads---------csslqgESEWWWDFLIQIRENILVSIANISGQIDFNVYPEEIVRPILDGLLHWAICPSATG 1755 red flour beetle
XP_001946583 1779 --DDdteslfncttttdadtiepgnDAKWWWDYLDVVRENLLVSLANIAGYVDLSTFNEDISRPILDGLLHWAICPAAAG 1856 pea aphid
EGT37977     1355 keKSvlde--------------vdaTTAQMVETANQLRDDAFVMLTHMSVSLNLFDLPDAIAYPIYDGLLRWSVSRVPEA 1420 Caenorhabditi...
XP_003112070 1313 keRSilde--------------advTTAQMVETANTLRDDAFVMLTHMSVSLNLYELPDAIAYPIYDGLLRWAVSRVPEA 1378 Caenorhabditi...

EDO30702      410 LDPMPTat--psTSLSAQQLVLEALAKMSILGGNAELIISTSSSPQLVLIHDTLVRLLGSRGNPVCRELTLVLLSNLSQS 487  starlet sea a...
3_pfamImport  144 TDSTTP------APVSPRDYALEIMCKLVVIERNVDMLLSTGSWSRIEQFVHILSRLLTMNEETHFREFAIVILNAFCVA 217 
XP_011680406 2470 LDPFPTms--sdSPLTPQRLAIEALAKLSIQENNVDMILATPPFHRLERLYSTLTQYLGERSDPVMRELSLVLLSNIARS 2547 purple sea ur...
EKC20059     2376 TDPLPStt---tSVLSPQRLVLEALSKLCIHETNVDLLLATPPFDRIVQLFSILTKLLANKSEPVTLEFALVLLSSLVQG 2452 Pacific oyster
EFX70974     1625 QDPFSSfgphstSLLSPQRLSLETLSKLMVMDCNMDLILATPPFLRLEKLVHFLTRSLCRTEDQVLREFAVNLLYYLSAA 1704 common water ...
EDX15823      355 QDPFPScg--pnSVLSPQRLALEALCKLCVTDANVDLVIATPPFSRLEKLCAVLTRHLCRNEDQVLREFSVNLLHYLAAA 432  Drosophila si...
EFA11411     1756 QDPFASvg--psSLLSPQRLALESLCKLCVTNNNVDLVIATPPFSRLERLCAVLTKHLCRSEDQVLREFSINLLHYLAAA 1833 red flour beetle
XP_001946583 1857 QDPFPS------APLSPQRLALESLCKLCVTDNNVDLVIATPPYSRLEKLANVLTRLLCRTEEQVLREFAVNLLHYLAAA 1930 pea aphid
EGT37977     1421 TDSTTP------SPVSPRDYSLEIMCKMVVIERNVDMFLSTGSWSRVEQLIHILSRLLTMNEETHYREFAIVILNALCIA 1494 Caenorhabditi...
XP_003112070 1379 TDSTIP------APVSPRDYSLEIMCKMVVIERNVDMFLSTGSWSRVEQFVHILSRLLTMNEETHYREFAIVILNALCIA 1452 Caenorhabditi...

EDO30702      488 DNEFAN-LGDKKQCIAMLLQFIEDAANSINAYSSGSSLAQGGyTSEDFCGTSVDML 542  starlet sea anemone
3_pfamImport  218 SEAICCiCAMETQAISHLILFIDAADQSMHQVMQTLGMNALR-DNPELMGTSVGML 272 
XP_011680406 2548 DMKASRaIATKNSIVSFLLRYIEDSEYTMSCEKNTPHMI-----NPDLAKPSHDMM 2598 purple sea urchin
EKC20059     2453 DTSCARaVAMQHPSISLLLDFLETAEHKAMTVANHHGINALR-DNPEIMGTSLDML 2507 Pacific oyster
EFX70974     1705 DSGMARlIALHNNSLALLVSFVEQAEANALAVASQHGIQALR-ENPESMGTSLDML 1759 common water flea
EDX15823      433 DSAMARtVALQSPCISYLVAFIEQAEQTALGVANQHGINYLR-ENPDSMGTSLDML 487  Drosophila simulans
EFA11411     1834 DSSMARtVASQTPCVSLLVAFIEQAEQSALGVANQHGIGALR-DNPDSMGTSLDML 1888 red flour beetle
XP_001946583 1931 DSGMARtIALQSPCVSLLVAFIEQTEQNALSVVNTHGLNALR-DNPDSMGTSLDML 1985 pea aphid
EGT37977     1495 SEAVCYiCAMETSTIAHLILFIDSADQNMHQVMQAHGMTALR-DNPELMGTSVGML 1549 Caenorhabditis brenneri
XP_003112070 1453 SEAVCFiCAMETTTISNLILFVDSADQNMHQVMQAHGMNALR-DNPELMGTSVGML 1507 Caenorhabditis remanei
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