pfam14475: Mso1_Sec1_bdg (this model, PSSM-Id:405207 is obsolete and has been replaced by 433978)
Sec1-binding region of Mso1
Mso1p is a component of the secretory vesicle docking complex whose function is closely associated with that of Sec1p. It is a small hydrophilic protein that is enriched in the microsomal membrane fraction, and this binding domain is towards the N-terminus of Mso1. The yeast Sec1p protein functions in the docking of secretory transport vesicles to the plasma membrane. Mso1p and Sec1p interact at sites of exocytosis and the Mso1p-Sec1p interaction site depends on a functional Rab GTPase Sec4p and its GEF Sec2p. The C-terminal region of Mso1 (not built) assists in targetting Sec1 to the sites of polarised membrane transport.
Jiyao W et al.(2023). "The conserved domain database in 2023.",