Conserved Protein Domain Family
BRI3BP
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pfam14965: BRI3BP (this model, PSSM-Id:405630 is obsolete and has been replaced by 464410)
Negative regulator of p53/TP53
This family of transmembrane proteins is found in eukaryotes. Proteins in this family are typically between 213 and 245 amino acids in length. It is found in various tissues, including the brain, liver and kidneys. It was first discovered as a functional unknown gene, murine brain I3 (BRI3). This protein is also known as HCCRBP-1 and it plays a role in tumorigenesis, as it binds to an oncogene, HCCR-1, and acts as a negative regulator of p53/TP53 tumor suppressor. BRI3BP induces tumorigenesis by activating protein kinase C (PKC) activity but decreasing the pro-apoptotic PKC-alpha and PKC-delta isoform levels. BRI3BP is over-expressed in many tumors.
Links
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Statistics
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PSSM-Id: 405630
Aligned: 14 rows
Threshold Bit Score: 155.946
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003796088  55 TFSQSVSSLFGEDNVRAAQK--------------------FLTRLTERFVLGVDMFMETLWKVWTELLDVLGLDVSNlsq 114 small-eared galago
NP_001082804  41 GFYQTLSNVFGEENIRALYK--------------------FFSKTTERFVHGVDSLLDTLWKLWVDLLDVMGIDSSNlth 100 zebrafish
XP_005988983  37 GLYRGLCSVFGEENIGALQR--------------------FFSKITDQFVCGMDVLVETLYRIWTDLLDVLGVDASNlth 96  coelacanth
XP_007229542  47 dghGFLVSLFGRQSVDSGLK--------------------TLREITTWALESTAGSLNILASYVTEVLGAAGITAN---- 102 Mexican tetra
NP_001139031  47 EAHSFLVSTIGEKRVDLSLK--------------------FLQSGVKWLSDAVASALNVAIRYITEILESAGIDAK---- 102 zebrafish
XP_006010221  50 AVLEGLEQVLGKELLQRALE--------------------FLTSCSEVIADGLSAGLRTLYRFANDGLRALGVEGER--- 106 coelacanth
XP_005046602 118 TTWDTLENWVGPQLLQMVAE--------------------SLSTTLWIVSSGISAALTTLCGILGDLLAASSISGHR--- 174 Collared flycat...
XP_016851049  54 AIRKTVEDLIGRDNFQILSE--------------------NLSSLLWIVSSGISSALLVVARVSGQFLTSFGLAGDH--- 110 green anole
XP_010709077  63 TTWASLEGCLGAEPLRLLAE--------------------SLLTALWLTASAISSGLAVLSSTVGDLLDACGLHGt---w 119 turkey
CAG06272      41 eVQRYAESAMGIGVVRSAVEsavlflesllgqenvytmamFLETVIRFLAEGAASGLNVIAVYVAEILRVTGFDIA---- 116 spotted green p...

XP_003796088 115 YFSPASVANSPARALLLVGVV-LLAYWFLSLTLGFTFSILhlvfGRFFWIVRVVLFSMSCVYILHKYEGEPENAVLPLCF 193 small-eared galago
NP_001082804 101 YFSPSSVSSSPARALLLVAAL-LVAYWFLSLFLSGFFYILhavfGRFFWLARVTLFALSCLYILQKFEGDPEKAVLPLCF 179 zebrafish
XP_005988983  97 YFSPTAVTSNPTRAVLLVGAV-LLAYWFLALFIGVLFSLLhavfGRMFWIVRVILFALSCLYILQKHEGNPEQAVLPLCF 175 coelacanth
XP_007229542 103 -LPVKRITPEGVAFVTKWVLLaVLVYWILSLAVCFVSGIV----QRTLWLVKITVAIAMFGLILSDTGATAETTAMRLAG 177 Mexican tetra
NP_001139031 103 -LPFQKVTPEGVIFVTQWAILaVLAYWILSFILRLVVGAV----RQALWLLKLSFAVGTFGLILSDSGASAETTALRLAG 177 zebrafish
XP_006010221 107 FTHFLNLSSQEVHTLLIWGAVaLIGYWLFSFLLHLILSVV----GRVFWLLKIGLFLSAFVYIITAYEDP-ARRATLLLV 181 coelacanth
XP_005046602 175 LVRAAALAPREVQRVLLWAVAaLLGSWVLSRLRRLLLPLL--------HWLKLFLFLCAFLHVAASQESP-TVQAGMLLG 245 Collared flycat...
XP_016851049 111 LTQFLKRSPDEVQTLLLWGLAaLIGYWLLSLVLSLLVAIL----SRIMWGLKVVLFVACFMFIVSSVPDR-SVQTLLLLA 185 green anole
XP_010709077 120 LAGSVALSPGAVQRVLLWGLLaLVGVHFLPWLLGLVVALL----RPVLHWLRLCAFLGAFLHVVAAEGSGLMVRAAMLLG 195 turkey
CAG06272     117 -VRLPLFTPEGVTAIAQWGLLaLFGYWVLSVLLHLLICVL----KRVFWVVKTVLALWLFGLIVTDKNATADTTAVRLWG 191 spotted green p...

XP_003796088 194 VVAVYFMTGPMGFYWRSNp---SNPNVEEKLEHLENQVRLLNIRLN 236 small-eared galago
NP_001082804 180 IMAVYFMTGPVGAYWRKGg---GSGTLEEKIDQLDTQIRLLNIRLS 222 zebrafish
XP_005988983 176 VVAVYFMTGPVALYRRRN-----SSTLEDKIDHLEGQIRILNIRLS 216 coelacanth
XP_007229542 178 LMLACILLGIGPSPFKGD----TNTHMEVKVKVLERKVRELEKKSK 219 Mexican tetra
NP_001139031 178 LACVCVLLGIGTASAKSD------AHLENKVKMLERRLKEMEKSKm 217 zebrafish
XP_006010221 182 LLVVYVLLGRFC---SSSe--sEVHYLRDRVRSLEGEVNNINRNme 222 coelacanth
XP_005046602 246 LWVLYALLGSL----VASp--dPSARLDAAVRNLEWKVEELRRRQK 285 Collared flycatcher
XP_016851049 186 LLTLYVLLGWL----SGSh--nSGTRLEAKIRGLERQVEELQRRQR 225 green anole
XP_010709077 196 L-----WGLYVLXGGGRApppsPGAHLEAAVRSLEWKVEELRRRQQ 236 turkey
CAG06272     192 LVLGCVLLNLL----KSDs--eKPCSTDTRLRNLEGRLRAVEKRKG 231 spotted green pufferfish
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