Conserved Protein Domain Family
DUF4588
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pfam15251: DUF4588 (this model, PSSM-Id:405848 is obsolete and has been replaced by 464591)
Domain of unknown function (DUF4588)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 200 and 274 amino acids in length. There is a conserved LYK sequence motif. There is a single completely conserved residue A that may be functionally important.
Links
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Statistics
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PSSM-Id: 405848
Aligned: 10 rows
Threshold Bit Score: 169.684
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EDK45185      19 EDERRRNTslsgtgaaaasvtssqstsstsstsstadYTDLTTHFKDAAKAIASLYNTALGVQNltntndetpQKLTLKT 98  Lodderomyces el...
XP_002616473  17 EQVSLVDL-----------------------------NRDLTNEFKNTAKAVASLYNATSQAEC---------EHRSAKT 58  Clavispora lusi...
XP_011456911  21 EEECIEELhsetnmeea------------lekqqelaEQKLWLQFQNSATAIAQLYK----DRH---------QGLSLWV 75  Pacific oyster
EFX87878      21 ERQCEIELenepdldqa------------vlserdlsTQKLWYLFQNSATSVAQLFK----DRN---------QPQVLWL 75  common water flea
XP_002595766  19 EQQCVEEVegegnmeer------------lageredvAQKLWLSFQNSATAVAQLYKGNTCNRG---------QGSHVWQ 77  Florida lancelet
XP_780508     23 EAQCLEELdrelepnlde----------rlpqekqfaSEKLWYSFQNCASAVTTLYKERLNQSN---------IHIPLWL 83  purple sea urchin
XP_003972349  25 ERQCLaeaeqsdp----------------keeeteqsQQKLWHLFQNSATAVAQLYK-DRVCQQ---------QGISLWV 78  torafugu
Q28HY5        25 ERQCLaeaeqedq----------------peeeaeqsQQKLWHLFQNSATAVAQLYK-DRVCQQ---------QGLSLWV 78  tropical clawed...
XP_006082091  38 pelqDdkddeddkgd-------------eealgpkseQQKLWHLFQISANSVAQLYK-GSECPQ---------SELSMWD 94  little brown bat
XP_023205108  25 ERQCLaeaetmdp----------------geeeadndQDKLWHLFQNSATAVAQLYK-DRVCHQ---------QGLSLWV 78  southern platyfish

EDK45185      99 DFAQAARSVAVLYKYAQ----MSHPASFDQGYLNCIDDLLqiitndedveNWALTRR-AEITKLQKTSNKDNERERkEKG 173 Lodderomyces el...
XP_002616473  59 EFSNAAKAVASLYRTGS----NSNVLSMHKGYLDCLDDMLrvitndedieSWVLTRR-AELTNSYNTNQNHGAGSPgRAS 133 Clavispora lusi...
XP_011456911  76 PFQNAASNVTSLYKDGVdslhNCVDFGIQKGKQYRNRDIV----------AWVKKKR-RNIRREDLLAFLCGKNPP-ARN 143 Pacific oyster
EFX87878      76 PFQTAAGTITSLYKESTealrRSSELGIQAGYQRRAREML----------AWAKKRRgRNIRREELIAFLTGKSVPgSGA 145 common water flea
XP_002595766  78 VFQNAAQAVTLLYKDSIdankRSEDFGIQCGYQRRTRDVV----------AWAKKRR-RHIRREELLAFLCGKTVP---- 142 Florida lancelet
XP_780508     84 VFQNAAGSVTQLYKESTdaqkGSLDLGISIGHQRRTRDIV----------AWVKKRR-RHIRREDLLAFLCGKAPP--GR 150 purple sea urchin
XP_003972349  79 PFQNAATAVTNLYKESTearqRSYDLGIHLGNQRRNKDMI----------AWVKKRR-RTIRREDLISFLCGKVPP---- 143 torafugu
Q28HY5        79 PFQNAATAVTNLYKESVdahqRSFDLGIQIGYQRRNKDVL----------AWVKKRR-RTIRREDLISFLCGKVPP---- 143 tropical clawed...
XP_006082091  95 HFQSAAMALTSLYKESRdaqqRSFNLGVQVGYQRRIKDVL----------DWAKKGQ-STILREDLISFLCGKVPP-DPP 162 little brown bat
XP_023205108  79 PFQNAATAVTNLYKESVeahqRSCDRGIQIGHQRRNKDML----------AWVKKRR-RTIRREDLISFLCGKAPP---- 143 southern platyfish

EDK45185     174 ERERDRDRDREREREREKD--------------------IEsdsvLNFSQKSVVKNSLDSLQSKtafddgk--------l 225 Lodderomyces el...
XP_002616473 134 VSHNTHERLTDEAFPVRTN--------------------KDsshrLRDFDEASSENSKKNTTEKkfsnngtandlsssql 193 Clavispora lusi...
XP_011456911 144 RHASSMVRHSQSSRLSVERthsprlqgp---eslssgnePD----LQAFREAIALQGLNGAMSN---------------- 200 Pacific oyster
EFX87878     146 SQPRHQMRMGPRPRVSLSDgmsashhgasalqhpleasaGDfepaLQAFREALSLPLPSSASSN---------------- 209 common water flea
XP_002595766 143 --SRTGSRSPPRS----TRdsprlgsqe---yapshqseID----LQPFKDAIALQGLNGAMAS---------------- 193 Florida lancelet
XP_780508    151 IRPSHGVPRSPSDRSSPRThsppreaqr----tglgepvdD----LQPFRDALALHGLNGAMAN---------------- 206 purple sea urchin
XP_003972349 144 ---PRAPRAPPRVASRSapqet------------gssveTD----LQPFREAIALQGLSGAMAS---------------- 188 torafugu
Q28HY5       144 ---PRNSRAPPRLTVVSPNratpte--------tgssveTD----LQPFREAIALHGLSGAMAS---------------- 192 tropical clawed...
XP_006082091 163 PVPPHLPPVPPQLPPVPPHlpppyspkm--atessssldFI----LQPFQEAINLHELSGAMAS---------------- 220 little brown bat
XP_023205108 144 ---HRSSRTNSRLAMVAPSranspae-------tgssveTD----LQPFREAIALHGLSGAMAS---------------- 193 southern platyfish

EDK45185     226 psdfaFQfaLDLRPPTAFRPSipplSVLHNPSQRNLAIskknrfhqqilkkV------------------HSSEDSSESE 287 Lodderomyces el...
XP_002616473 194 htdyeFSlpQELMSHVVFRPSfpplSVSFKRSKKWCDIkdrk-----mpisL------------------QDASGSSDCD 250 Clavispora lusi...
XP_011456911 201 -----ITmgFSMSQGATASP-----QIGALPKSNG------------------------------------NMEELNRFI 234 Pacific oyster
EFX87878     210 -----NS------------------GSSAKSNGRRGSP-------------V------------------HNHSELSAFI 235 common water flea
XP_002595766 194 -----FG----LRTPTSPSH-----NMHSTPSRRR------------------------------------NLGELHAFI 223 Florida lancelet
XP_780508    207 -----IG--------VSQSP-----SSHHSSSRRR------------------------------------HLSNHDLF- 231 purple sea urchin
XP_003972349 189 -----IS--VRSGPPGSPTHP------AQPHGRRRNGL-------------H------------------D--VDLNTFI 222 torafugu
Q28HY5       193 -----IS--VRSSTPGSPTHV----SGSSNTGRRRNGL-------------H------------------D--VDLNTFI 228 tropical clawed...
XP_006082091 221 -----IS--VQSGPPSSPSQAgafsSNVATGDLQNSST-------------L------------------K--EDLSSCN 260 little brown bat
XP_023205108 194 -----IS--VRSGAPGSPTHV----SGSSSNTGSVSGG-------------GgassgsgpvcrsrrnglqD--VDLNTFI 247 southern platyfish

EDK45185     288 SDD------------------LKRVKifkdNT---SPSRKKKR 309 Lodderomyces elongisporus NRRL YB-4239
XP_002616473 251 SDDgitd----------adikKKRLA----HSlheVPKRQKRA 279 Clavispora lusitaniae ATCC 42720
XP_011456911 235 LDEfsrn----------ydtaRKRTSsp-dNTlidSPSRKKSR 266 Pacific oyster
EFX87878     236 SHEsar-------------hkRPAPAspthDVimdSPTHKRSR 265 common water flea
XP_002595766 224 SEEfanhmd------snspngRKRSSg--nDLlgdSPVHKRSR 258 Florida lancelet
XP_780508    232 PEDlvsh-----------pdsRKRSStniaPTvegSPSHKRSR 263 purple sea urchin
XP_003972349 223 AEEmarhm--------dstatRKRGPtpcsDVitdSPTHKRNR 257 torafugu
Q28HY5       229 SEEmalhl--------dnggtRKRTSaqcgDVitdSPTHKRNR 263 tropical clawed frog
XP_006082091 261 SEDlalhl--------asggnLKRTSgqcdDVitnFPTHKRNR 295 little brown bat
XP_023205108 248 TEEmarhldstgagaaggggnRKRNStqcsDVitdSPTHKRNR 290 southern platyfish
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