Conserved Protein Domain Family
Sec3-PIP2_bind

?
pfam15277: Sec3-PIP2_bind (this model, PSSM-Id:405869 is obsolete and has been replaced by 464608)
Exocyst complex component SEC3 N-terminal PIP2 binding PH
This is the N-terminal domain of fungal and eukaryotic Sec3 proteins. Sec3 is a component of the exocyst complex that is involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.This N-terminal domain contains a cryptic pleckstrin homology (PH) fold, and all six positively charged lysine and arginine residues in the PH domain predicted to bind the PIP2 head group are conserved. The exocyst complex is essential for many exocytic events, by tethering vesicles at the plasma membrane for fusion. In fission yeast, polarised exocytosis for growth relies on the combined action of the exocyst at cell poles and myosin-driven transport along actin cables.
Statistics
?
PSSM-Id: 405869
Aligned: 109 rows
Threshold Bit Score: 62.5517
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_027872525       29 RHFLCVSVGQKk-----vVQLSVVhcqisqstqksgskKLQTkRSSiqecYKRTEIWSLHDLTLVDGRDPDVDdscFLLH 103  Monterrey...
XP_002173379       60 PRYIVFTTDEDth----vLYLHRF--------------KYDK-TG-----MIIVKSWPLFELQSVTVDGELD----LSFT 111  Schizosac...
XP_013023235       53 PRYIVLSYDENth----vFYIHRL--------------KASD-KGG----MTVVRTWPLFELQGITVIDDRD----VTFT 105  Schizosac...
EGD72019           34 TNFLCLTVKTNe------SFLHRV--------------RVTT--DEs---YTKKKTWPLQALTAID--NVAPDsrqFILT 86   Salpingoe...
EFC49848           49 lttkkkMITTSkkkkgytIQVLVI--------------RRDK-EGI----FHIEKSYKLKRLAKIEGSEEG-SdmeFILH 108  Naegleria...
XP_001758232       59 PRVLALTVMRSaatqkfkVKLHVL--------------KQTP-TG-----MQSAKIYKLKNLNKVEAVSSDNSgctFVLG 118  Physcomit...
EFJ12163           49 PRVLAIACKRSpttqkfkVTLHVL--------------KYSS-SGFqariVVRAKLYKMKHLSRVEVVPSDSTgctFVLG 113  Selaginel...
Q53Q77             56 PRVLAVTTKKKgqr--tkAFVRVL--------------KYSN-GGV----LEPAKVYKMKHLSKVEVVPNDPSgctFLLG 114  Japanese ...
XP_009388937       50 PRVLVLTTKHSpkgertkAFLRVL--------------KYSS-GGV----LEPAKLYKLKHLTKVDVISNDSTgctFILG 110  wild Mala...
JCVI:AT1G47550.2   52 PRVLALSVKSKgpr--kkAFLRVM--------------KYSS-GGV----LEPAKMYKLKHLSKVEVITNDPSgctFTLG 110  thale cress
XP_027872525      104 FD-------KVRTVTAVTCSAKYTMVRALVALCDR 131  Monterrey platyfish
XP_002173379      112 IN-------KSHLFHCRNARERNIFVYTIARNYMF 139  Schizosaccharomyces japonicus yFS275
XP_013023235      106 IN-------KPHLLRSNDTLARNKFIFSLAKQFMH 133  Schizosaccharomyces cryophilus OY26
EGD72019           87 FD-------RSYEWIAPNVTEKQRFLEAIVKSCRR 114  Salpingoeca rosetta
EFC49848          109 FTnh----vKPFKIISDNVEQKNIFISKLLQVCRE 139  Naegleria gruberi
XP_001758232      119 FDnlknkpvAPPQWTLRTRDDRNHLLTGILKLCKE 153  Physcomitrella patens
EFJ12163          114 FDnlkiqnvAPPQWTMRNVDERNRFLTTVIRLCKE 148  Selaginella moellendorffii
Q53Q77            115 FDnlrsqsvSPPQWTMRNKDDRNRFLMCILNMCKE 149  Japanese rice
XP_009388937      111 FDnlrsqsvAPPQWTMRNIDDRNRLLLCILNMCKE 145  wild Malaysian banana
JCVI:AT1G47550.2  111 FDnlrsqsvAPPQWTMRNTDDRNRLLVCILNICKD 145  thale cress
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap