Conserved Protein Domain Family
PAG
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pfam15347: PAG (this model, PSSM-Id:405932 is obsolete and has been replaced by 434654)
Phosphoprotein associated with glycosphingolipid-enriched
PAG, or Cbp/PAG (Csk binding protein/phospho-protein associated with glycosphingolipid-enriched microdomains) is a transmembrane family that has a negative regulatory role in T-cell activation through being an adapter for C-terminal Src kinase, Csk. This family of proteins is found in eukaryotes.
Links
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Statistics
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PSSM-Id: 405932
Aligned: 11 rows
Threshold Bit Score: 394.581
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007659574   2 GPAGGLLS-SG--QVPVVFWGSLATVGTFlLLLTFLLFLCSSCDREKKPK---QSGDHENLMNVPSDKGLLSHSVTSLTT 75  platypus
XP_012396700   2 GPEGSLLH-GG--QVHIIIWGSLAAVATF-LLITFLIFLCSSCEREKKPKq--QNGDHENLMNVPSDKEMFSHSVTSLGT 75  Tasmanian devil
XP_016848323   2 GPDVGFFS-TS--LLHIIVWGGLAAMTML-LVLIFLIFLCSSCDREKRPKq--LNGDHENLMNVPSDKEVFSHSVTSLAT 75  green anole
XP_003205191   2 GPDSGFLS-SG--RVHVILWGSLAAVTTL-LFLTFLIFLCSSCNREKKSKh--QNGDHENLMSVPSEKEVFSHSITSSAT 75  turkey
XP_005997607  10 GDEEGLLS-SG--QPQVVLWGTLAAITSF-LLLNLLVFLCTSCEREQKAKt--QTEDHEILMNMPSDKETFSHSVTSLGT 83  coelacanth
Q3U1F9         2 GPAGSVLS-SGqmQMQMVLWGSLAAVAMF-FLITFLVLLCSTCDREKKPRq--HSGDHENLMNVPSDKDMFSHSATSLTT 77  house mouse
XP_006102204   2 GPSGSLL--GG--HLQIALWGSLAAAATF-FLITFLIFLCSSCDREKKPRq--YSGDHENLMNVPSDKEVFSRSVTSLAT 74  little brown bat
Q9NWQ8         2 GPAGSLLG-SG--QMQITLWGSLAAVAIF-FVITFLIFLCSSCDREKKPRq--HSGDHENLMNVPSDKEMFSRSVTSLAT 75  human
XP_003408410   6 GPVGSMLSiSG--QVQIVLWETLAAVAIF-FLIAFLIFLCSSCDREKKPRp--QSGDDENLMNVTSDKEMFSHSVTSLAT 80  African savanna...
XP_005478543  22 aastgvaSwLG--SGQLILIATLSILTAL-LLVSVLLLLCASCQGQKKAVnghPAGDHQSLVNGVSERDV-SQSADSPAT 97  Nile tilapia
XP_002936667   8 magspsnDlSGe-QAAFMAWGGLAAVSTI-IFLSILLFLCSSCyREKKKKh--QNGDHENLMTAPSDKETYSHSVTSLGT 83  tropical clawed...

XP_007659574  76 DAAASSEPNGGLSNGDILSEDSTKAYTLPYEEVQTSVSDLLDSQESVGKSIKCHQSRELPRIPPNGTL--EPILPPRTEA 153 platypus
XP_012396700  76 ELPASSEQNGGLTNGDILSEDSTMTCMQHYEEVQTSISDLLESQDSTGKSAKCHQSRELPRIPPNDTL--DTILTTSNVE 153 Tasmanian devil
XP_016848323  76 DPLASSEQNGGLSNGDVLSEDSTTACIQPYEEVQTSVTDLLEPQDSLGRSLKCHQSRELPRIPPNNAI--ETILSTRNTE 153 green anole
XP_003205191  76 EPPPSSEQNGALSNGDVLSEDSTTACIQPYEEVQTSISDLLE-QDSLGKSLKCHQSRELPSIPPNNTM--ETIISARNAE 152 turkey
XP_005997607  84 DPPVSSCQNGELSNGDVLSEDNAGTNTQPSEEMKTSLPDLISQQDSMGKPLRYPQSRELPSIPPNSSV--EGPKSSNATE 161 coelacanth
Q3U1F9        78 DALASSEQNGVLTNGDILSEDSTLTCMQHYEEVQTSASDLLDSQDSTGKA-KCHQSRELPRIPPENAV--DEILTARAAD 154 house mouse
XP_006102204  75 DAPLSSDQNGALTNGDIASEGSAGTCAQHYEEVLAAASDLLDAQDGSGKP-KGHQSRELPQIPPDSAV--DTLASTGSVD 151 little brown bat
Q9NWQ8        76 DAPASSEQNGALTNGDILSEDSTLTCMQHYEEVQTSASDLLDSQDSTGKP-KCHQSRELPRIPPESAV--DTMLTARSVD 152 human
XP_003408410  81 DALASSDHNGALTNGDILSEDSTMTCMQHYEEVETSASDLLDSQDSAGRPSKCHQSRELPRIPPNSTV--DTTVNASSVD 158 African savanna...
XP_005478543  98 DAAVSTSHNGPLTSGTILT-DTQDTSPQLSEEMLSSQSEL--------RSSKCPQDRELPSIPPNNALigNGPPPSGDST 168 Nile tilapia
XP_002936667  84 EAPASY-RNGAVSNGDV-SEDSSAACIQPYEDVQGSLPDLCDLQDCTSKSIRCHQSRELPRIPPNSNL--ETISPAEDDE 159 tropical clawed...

XP_007659574 154 RERGLGTEGPYEVLKV--SCSQENMVEDCLYETVKEIKEAGASADAD-------------------PSHGGghQEGSATA 212 platypus
XP_012396700 154 SDQGLGMEGPYEVLKD--SSSQENMVEDCLYETVKEIKEVGTSANLE-------------------KGQNG--RPNSVTA 210 Tasmanian devil
XP_016848323 154 NDQGLGMEGPYEVLKD--SSSQENIVEDCLYETVKEIKELGATSGTE-------------------KC-----KPKTAVL 207 green anole
XP_003205191 153 NDQGLGMEGPYEVLKD--SSSQENIVEDCLYETVKEIKDVGAAANME-------------------RSCNR--KSAASMM 209 turkey
XP_005997607 162 NDQALVTDVTYEVLKD--SSSQDNIIEDSLYETVKELKEECGPARND-------------------TASLS--RPSTTAE 218 coelacanth
Q3U1F9       155 TELGPGVEGPYEVLKD--SSSQENMVEDCLYETVKEIKEVA-----D-------------------KGQGG--KSKSTSA 206 house mouse
XP_006102204 152 GDQGAGAEGPYEVLKD--SSSQENMVEDCLYETVKEIKEAAAPPG---------------------KGPGG--RSRAAPA 206 little brown bat
Q9NWQ8       153 GDQGLGMEGPYEVLKD--SSSQENMVEDCLYETVKEIKEVAAAAHLE-------------------KGHSG--KAKSTSA 209 human
XP_003408410 159 GDQSGGMEGPYEVLKD--SSSQENMVEDCLYETVKEIKEVGATTHPD-------------------KGHNG--KSKSITT 215 African savanna...
XP_005478543 169 Y----------EVVKEmaVASRDVSADESLYETVKELKEPAAEAGLPngtiqpspdeppphppallNGHVS--------- 229 Nile tilapia
XP_002936667 160 NELPLGNEGPYEVLKD--SSSHENIIEDSLYETVKEIKDAHALPLNE-------------------ETERS--------- 209 tropical clawed...

XP_007659574 213 GRGLLGSV-SEGQTGS-----AEYASVDRNKKGRQSLSAESVLGG-LADL---------EEEAPPPVPVKLLDENENVWE 276 platypus
XP_012396700 211 FKEIQGPQ-VLNKIES-----AEYASVDRNKKSRHSVNAESILGN-SVDV---------EEEAPPPVPVKLLDENENVQD 274 Tasmanian devil
XP_016848323 208 VNGSLDHV-LAHKVES-----AEYASVDRNKKSRQSANSESPLSN-TPDV---------EDEPPPPVPLKLLDENENVQE 271 green anole
XP_003205191 210 VTEDQDQI-PECRIES-----AEYASVDRNKKSRQSANSESPLDN-TPDI---------EDELPPPVPMKLLDENENVQE 273 turkey
XP_005997607 219 EVEAQSPEnAAGATQS-----AEYASVDWNKKSHRSQVLCAGDRA-SANS---------DEEAPPPVPTKILDENENVQN 283 coelacanth
Q3U1F9       207 LKELQGAP-MEGKADF-----AEYASVDRNKKCRHSANAESILGT-CSDL---------DEESPPPVPVKLLDENANLPQ 270 house mouse
XP_006102204 207 PKEPPAPQ-APGRADF-----AEYASVDRNKKCRQSMNVDSVLGP-ARDA---------EEEAPPPVPVKLLDKNENLQA 270 little brown bat
Q9NWQ8       210 SKELPGPQ-TEGKAEF-----AEYASVDRNKKCRQSVNVESILGN-SCDP---------EEEAPPPVPVKLLDENENLQE 273 human
XP_003408410 216 LKELPEPQ-TQGKMEF-----AEYASVDKNKKCRQSANSEIVLGS-SHDP---------EEETPPPVPVKLLDEKENLQE 279 African savanna...
XP_005478543 230 ---------PSTPERGpifagAEYASVNLNKKSRHSADMEAKRRSgNAAVpqqkpqeepEEDLPPPVPEKVLDENDN--- 297 Nile tilapia
XP_002936667 210 ----MDAV-SPKRQEFrieagAEYASVDHNRKSRQSINTQSAGST-PTSQ---------EEDVPPPLPKKLLDENENVQS 274 tropical clawed...

XP_007659574 277 KEder-saAVKEEEGEASESPVDTSKRLSSLSYKSREDDPALTEEEISA-MYSSVNK-PGLA--------------NRLA 339 platypus
XP_012396700 275 KV------DGETVNKGATESTGQINKRLSSLSYKSREEDPTLTEEEISA-MYSSISK-PGQT--------------LKVP 332 Tasmanian devil
XP_016848323 272 KE--------AEEEKEATEGPSDPDKRLSSLSYKSREDDPSLTEEEISA-MYSSVNK-PGLA--------------TRDL 327 green anole
XP_003205191 274 NE---------VDEGEGTEGASKPEKRLSSMSYKSREEDPSLTEDEISA-MYSSVSK-PGQA--------------IRAM 328 turkey
XP_005997607 284 KG----------TEGEHLKEASEVEKK--RLSYRVHGDGPPLTEEEISA-MYSTVNR-PAQS--------------VKSL 335 coelacanth
Q3U1F9       271 EG------GGQA-EEQAAEGTGGHSKRFSSLSYKSREEDPTLTEEEISA-MYSSVNK-PGQSahkp-------gpcMKGP 334 house mouse
XP_006102204 271 Q------------DNSASEGTQETNKRFSALSYKSREEDPTLTDEEISA-MYSSVNK-PGQS--------------LKVP 322 little brown bat
Q9NWQ8       274 KE------GGEA-EESATDTTSETNKRFSSLSYKSREEDPTLTEEEISA-MYSSVNK-PGQLvnks-------gqsLTVP 337 human
XP_003408410 280 KE------ERPADEEGATEGTTEINKRFSSLSYKSREEDPTLTDEEISA-MYSSVNK-PGQSvnkpgqsvnksaqllqVP 351 African savanna...
XP_005478543 298 -QpalmmnGLAEAGLHNGE-------LHSPPSPAPKFDNHVLSDNE--SaVYSTVNKtnc-------------ddaVNEE 354 Nile tilapia
XP_002936667 275 KEpeaepeAEPEALKENIEGASQDDKRQSLVSYKSREEDPCLTETDISA-MYSTVSKtSGQS--------------FELQ 339 tropical clawed...

XP_007659574 340 P--APSVAIQEVGPPRSPSSSNDLYATVTDFENLTDg-qEPPPP--RR-DNEPEPDYAAIQ----SLGRDEGRAGPGPER 409 platypus
XP_012396700 333 E--STYSCIQEVAPKRSPSSGNDLYATVRDFEKNPN---ILPPPgvHS-NGEPEPDYEAIQ----SLNKDEEKTVSMANG 402 Tasmanian devil
XP_016848323 328 E--PAYTCIPEIAPQKSPSICSGLYASVKDLENTPNi-tTFPQSgeRL-NGELEPDYEAIQ----TVHHDEDRNGLIPHS 399 green anole
XP_003205191 329 D--SPYTCIQEITSQRSPSVCSGLYASVKDFENTLSa-tTVPQSagRP-NGELEPDYEAIQ----AVSQDEDRTLSVPHT 400 turkey
XP_005997607 336 E--CDYVEVKALSLERTPSMNSDLYATVRDFEKEPNvlwPTPSPsdQTiQQETDPGYEPIS----SVKNEDETTESQLSA 409 coelacanth
Q3U1F9       335 E--SACHSMK-GLPQRSSSSCNDLYATVKDFEKTPNs-iSTLPParRP-SEEPEPDYEAIQ----TLNREDEKVPLETNG 405 house mouse
XP_006102204 323 E--SSDTCSP-GAARRSPSSCNDLYATVKDFEQPPSg-aGTLAPaaRP--REPEPDYEAIQ----ALSREDEKATLEPSS 392 little brown bat
Q9NWQ8       338 E--STYTSIQ-GDPQRSPSSCNDLYATVKDFEKTPN---STLPPagRP-SEEPEPDYEAIQ----TLNREEEKATLGTNG 406 human
XP_003408410 352 E--SSYTCIQDGAPQSSPSSCNDLYATVKEFEKAPNs-vSTPPPaeRP-SVEPEPDYEAIQ----TLNREEEKATQETNG 423 African savanna...
XP_005478543 355 DkeHDYSSIAEIKGLVPASSSGDLYATVRDIYSQPDe--pGPA-------DSTDPGYETIRipktNSSEDEHRA----EG 421 Nile tilapia
XP_002936667 340 EefSHYAYIQDIAQDTSPTTCNGTYATVRDLDKSPDs-iAGPHAmdKA-NGGPDPEYEAIA----NLSREEERTMLYTNA 413 tropical clawed...

XP_007659574 410 GRPLPAQpESDYESIGDLHHGKDFTRL 436 platypus
XP_012396700 403 NHITFPK-ENDYESIGDLQQSKDITRL 428 Tasmanian devil
XP_016848323 400 SQSTLSQ-ENDYESIGDLQQHKDVTRL 425 green anole
XP_003205191 401 NHIAPSG-ENDYESIGDLQHHRDVTRL 426 turkey
XP_005997607 410 SPATDQKiENDYEIISEFQKD-EITRL 435 coelacanth
Q3U1F9       406 HHV--PK-ESDYESIGDLQQCRDVTRL 429 house mouse
XP_006102204 393 LRGPFPK-ENDYESIGDLQQCREVTRL 418 little brown bat
Q9NWQ8       407 HHGLVPK-ENDYESISDLQQGRDITRL 432 human
XP_003408410 424 LHVLFPK-ENDYESIGDLEQCRSITRL 449 African savanna elephant
XP_005478543 422 SDVGKA--EPDYESVGELGLGPEMSRL 446 Nile tilapia
XP_002936667 414 GQTLLAHgESDYESIGDLVQNGDFTRL 440 tropical clawed frog
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