Conserved Protein Domain Family
DUF4659
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pfam15558: DUF4659 (this model, PSSM-Id:406094 is obsolete and has been replaced by 464768)
Domain of unknown function (DUF4659)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.
Links
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Statistics
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PSSM-Id: 406094
Aligned: 27 rows
Threshold Bit Score: 241.455
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EGV92516     173 EISSRDQKILALVLSRLKKAQKMRELQQQAAVAWEELKRSDKKVHMTLERERRLLLQQSQEQWqGQKEQHKSRRdheqlr 252 Chinese hamster
XP_002199374 223 EVPERDKKIAALMIAKHQEASLLREQRQAAHLQWDSQRRLAEQRKEREEKEKQRALLQGQRMWeSQVEKRRGRL------ 296 zebra finch
XP_008116349 328 EVPERDRKIAALMIAKRQEESLLSAQRYSAHLQWDTQRRRAEQRKEQEEREKHRALVQGQRMWeSRLEKHRRRR------ 401 green anole
XP_005623634 331 GVPDRDRKIAALMLARHQEERLLLEQRAAAHGQWEQQRVRAEQRREREEREKQRALEQGRRAWaAQVEERRGRR------ 404 dog
XP_003756429 342 GLPERDRKIAALMLARHQEEELLREQQAFAHSQWELQRKKTMQQREKEEKEKQRVLAQCRQAWtAQVEERLGRL------ 415 Tasmanian devil
XP_006011788 266 EVPERDRKIAALMLAKHQEENILSEQRHMAYLQWDSERKRNELRKEREEREKQRALLQCHKMWeSRVEKRRWKM------ 339 coelacanth
XP_003976806 447 AVSERDRKIAALMLAKYQEEDLMSQTRYVAHLHWDSERRMEELRREQENREKQRSMMEYQRVWhTQVSLRQQRL------ 520 torafugu
XP_015206663 338 EVPERDRKIAALMLAKHQEEDIISRTRYVAHLQWDSERRLEEMRREREEWEKQRAVLQCQRMWhAQVAMRQRRL------ 411 spotted gar
XP_002111183 227 GVPEKDRKIIELMLNRHREEEESDRVRRLANLNWEQQRLALDEKMAMNLNRKKEEIRESNRARlAAQEQQKAKV------ 300 Trichoplax adha...
XP_002935376 318 ELPQRDKKIAAIMIAKHQEENIRKEQRYLAHIQWDIQRKNSELRKEQEEKERQKALLHGQRSWeRHMKSR---------- 387 tropical clawed...

EGV92516     253 qGYEQQg-ERR------DRQEKSTIqaqaESQSRWPEQPDNPENGDLDKLDRVHAQAEHLKQCQMQRLQEQERVLQSLRD 325 Chinese hamster
XP_002199374 297 -NQEQE--EAA------LMRQKQLL----VCEERWREQAEKQERLRRERLERAIKEDKQKKLHQELNLKAKEEVKKEHQE 363 zebra finch
XP_008116349 402 -SSEQE--EAA------LQKQRQSL----MVEEKWQAHLERQEGLRKAKLEKAAQEDKRKKRHQEHNLKAQEEGKKEAVE 468 green anole
XP_005623634 405 -GREER--EEA------RRRQRQCE----RSEERRRELAERQGLLRRERVERAAREDRLRKLQQEQNLKQREEGLQEGRE 471 dog
XP_003756429 416 -GHQER--KAA------RRLRSQYA----RGEEQRLELLERQGQLRLERAQRAAFEDRMRKLQQEHNLKLWEEGRQKERE 482 Tasmanian devil
XP_006011788 340 -TQEKR--DTA------SFKQQQTM----TQEEKWREQAEKQERARKEKLEKARQEEQQKKLHQEQNLKIKEEEKKVTLE 406 coelacanth
XP_003976806 521 -SHQEQ--MSA------AAKMRQAE----ENEERWRELSEQQERSRLLRLQQAAREEKHKKVLQEQNLKALEEERAAMLE 587 torafugu
XP_015206663 412 -SQEQQ--QAT------IQKMLHVA----ESEERWKELAEMQEHSRQEKLRQAAQEQKQKKCLQEQNLKALEEERQAMLE 478 spotted gar
XP_002111183 301 -DYENEvqRKF------KIEKIQ------EKDAKLAAITSAKQKLLEQQIQLKILQDQSKKKNQEYNLKVEEEYRNAKAI 367 Trichoplax adha...
XP_002935376 388 ---ENR--NSVgemstaSLTQSKSP----LLEEKGKDQVQELEKIKGEKLANT-QTVKQKKSKEEKK------------E 445 tropical clawed...

EGV92516     326 LNRLQMQKKLEVTCHKRQQHlPEESQKKVPENNLsSSIINFQARKVLMDCQAKAEELLRKLSLEQSSQSSQDVQEDLAKE 405 Chinese hamster
XP_002199374 364 REEQLLQEKLSTAAQKRLKK-EVQLQKEKRLFNQ-AEKLKHEALLKELAKQEAEEKEMLKASLKMSLTKAQENYEQLVEK 441 zebra finch
XP_008116349 469 REVQLLQDKLTLAAQKKLRK-EQLLQKEKQLLNQ-AEKRKHEAILKELAKQEVEEKAMLRASVEGSLNKAQENYEQLVER 546 green anole
XP_005623634 472 RAELARRERAQRAARTKQRQ-EGQLQREKRELSR-AERARHEALLQGRARQERAEREGLRSSLEASLGRAQENYEQLVEQ 549 dog
XP_003756429 483 RVDYARRERAEIAAQTKRKQ-DTHLQREKQQLSR-AERAHHEALLQGLARKERKEQEGLRLSLEASLERAQENYEQLMEQ 560 Tasmanian devil
XP_006011788 407 QEGQMLQEKLTSAEQKKLER-ELQQQQERKSLSK-ADQLKHQALLKELAKQTQMEKKMLRKSLEQNLSKAQENYEQLVEK 484 coelacanth
XP_003976806 588 QERLLLKEKLTMAELKRQEK-EHQAQEDRRGLNK-AERRRHAALIQEIARREQEEREEARRAAEEKLSRSLENYEQIVER 665 torafugu
XP_015206663 479 QEQLLLQEKLTMAELKKQER-EHQFQKERRGLNR-AEKMRHGALIKEIAGREVEEREMARKSMELRLSRSIENYEQIQER 556 spotted gar
XP_002111183 368 QNHLRNLRIEENARINRQIR-SREDQLRIGANNL-KSELEHDKKKYDNEMKTREDQHYLQNSIELKHLRADTNYKRQQQI 445 Trichoplax adha...
XP_002935376 446 QEGGLFQDKLLVAQHKKKEN-EEQLHISKSLQNK-AEKMKHQAMAQELTQKKEYETEELRKTLQKNLQKAQENVEQLLEK 523 tropical clawed...

EGV92516     406 RHREQQGKAQKEAEQFQRVRWRTEEAEErRRQERQRVLAELAEQKIRQARCHEHKTSKDRVQHLQELSVLRERNNHILKL 485 Chinese hamster
XP_002199374 442 RNQELREKARREDMQIQRAKLAAEKKEK-EQKEHLEALARETERKLQHAAQVAEEAVQEKARKVVLSRLEKEKVQKMNKQ 520 zebra finch
XP_008116349 547 RNRELRERAKREDQQIQRAKLAAEKREK-EQKEHLKALAKVSERKLQHATQVAEEVVQQKARKVVQSRLEKEKVQKVNKK 625 green anole
XP_005623634 550 RARELRERARREELQGRRAKEVAERKER-EHQAHLEALARAGERRLQHAMQAAEEAVQQKARRVGQSRLEKERAQRANKE 628 dog
XP_003756429 561 RSRHLRERARKEELQGRRAKEVAERKGR-EHQEHLEALAKAGEQRMQHATQVVSEAVQLKARRIGQSRLEKERAQRANKE 639 Tasmanian devil
XP_006011788 485 RNQELKERAKKEELQIQRARLAAEKKER-EHREHLEALAKLAEKKLQHAAQVAEETAQQKARRAVQSRLEKEKLQRLNKQ 563 coelacanth
XP_003976806 666 RGQELKEKAKREEKQIQKARKAAERRDK-QQQQLLEARMKEAEKRAKHAAVVAEEKAKEKAQRAVQSRQEKERLQRLNRQ 744 torafugu
XP_015206663 557 RHQKLKGKARKEEQQIQKARQVVERKEQ-QQKEHIEALAREAERRAQQATQVAEERAKERAFKAVQSRLEKEKIQRMNRQ 635 spotted gar
XP_002111183 446 KAEEMRAEIMKMQKQFRKQQETAKLMTE-EHDEWLKHLQLEEDLKLEKAETIAALVKEEKRFRAKEQREARQAGQKLNMK 524 Trichoplax adha...
XP_002935376 524 RNQELKERARKEELQILRAKQAAEKQEQ-GRQEHLQKLAIVAEKRLQHAAQVAEEVVQHKARKAIECRLEKERIQRENRQ 602 tropical clawed...

EGV92516     486 KAEKEEKCHIEGIKEAIKKKEQRVEQMTRWKDPIFQEFQKVPSASktDR----------CFDYVAAETQLPAHHLS 551 Chinese hamster
XP_002199374 521 KVEQYEDLRRREILLSIERKLERSEQIFKEKKTVLENARSVARASfhVRekvreetnmrTFDKMAFEAELHAQLSK 596 zebra finch
XP_008116349 626 KVEQCEDIRRRELLLSIEKKLERSEQICKEKKNILENARSVARASfhVRekvreemnirTFDKMAFEAEMQATLVK 701 green anole
XP_005623634 629 KVERDEDCRRRELLQAIGRKLERSEQLSRERRSALESARSTARASfhVRekvreetntrSFDRMVRDAQLHASLDR 704 dog
XP_003756429 640 KVDRAEDSRRRELQQAIERKWERSERLSRERRSALENARSTARASfhVRekvreeintrTFDRMALEAKLHANLGK 715 Tasmanian devil
XP_006011788 564 KVEQDENFRRKELLMSIEKKLERSEQIFKEKKTVLENARSIARASfhVRekvreetnvrTFNKMALEAELHANLDK 639 coelacanth
XP_003976806 745 RVEEEEKQRRLELLQSIERKLEKSEQIFKEKKAVLESARSVARASfhVRdkvreetnvrTFDKMVLEAQLKASLDE 820 torafugu
XP_015206663 636 RVEELEQHRRQELLLSIEKKLEKSEQIFREKRAVLESARSVARASfhVRdrvreetnmrTFDKMALEAKLKASLNE 711 spotted gar
XP_002111183 525 KIKKQEELKQRYTTAQAMSKDRKRQQIAAAKEENLSKLRDTARATslMRykvkemtaksSIGILL--ESLGTDQHH 598 Trichoplax adhaerens
XP_002935376 603 RVQKNEDMKRKELLESIEKKLERSDHIFRERQTVLDNARSVARASfnIRekvraetntrTFDKMAFEAELYANINK 678 tropical clawed frog
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