Conserved Protein Domain Family
Mif2_N
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pfam15624: Mif2_N (this model, PSSM-Id:406137 is obsolete and has been replaced by 434820)
Kinetochore CENP-C fungal homolog, Mif2, N-terminal
Mif2_N is a family of fungal proteins homologous to mammalian CENP-C. On depletion of CENP-C proper formation of both centromeres and kinetochores is prevented. The N-terminal of CENP-C is necessary for recruitment of some but not all components of the Mis12 complex of the kinetochore.
Links
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Statistics
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PSSM-Id: 406137
Aligned: 36 rows
Threshold Bit Score: 103.94
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EFX05500      19 IYTLGERGRKTGVTLRDTGVRDEHGMEPMESIFSSPAKSspgdaldasGDEQVEEDGGEEDDDDGGE-VDMDLTTV---- 93  Grosmannia clav...
Q2UBG4        14 YSNVGKLGRRTGITVKE-GKRDEHGMEDIDEMWSSPEKSp--------VRENGFSNG---NESLVGS-DGMSMDEG---- 76  Aspergillus oryzae
EGE07298      15 YSNVGKAGRRTGITLKE-GKRDEHGMEELEGMFSSPEKSp--------VRTNGFANDGLVNS------EEMETGGT---- 75  Trichophyton eq...
XP_002485013  14 YSNVGKQGRRTGITLKE-GRRDEHGMEELDGVFSSPERSp--------VRMNGLNTG---NDTVMGS-EGMSIDEE---- 76  Talaromyces sti...
XP_007777144  16 FHDIGVQGRKTGITLKDTGIRDEHGFEPIEGMFSSPEKP--------------SPRRTSRRTDVTLTsEEMEVQQS---- 77  Coniosporium ap...
EKG19725      13 YFNVGVQGRKTGITLKDTGIRDEHGLEPIDGIFSSPEKS------------PPTRNNSRQQPDKTLTsSDMDLQHSmlrh 80  Macrophomina ph...
CBX96946      14 FYDVGVQGRKTGITLADRGVYDEHGLEALSGVFSSPEKS-----------------PPKRSGTVTAS-ESMDIQES---- 71  Leptosphaeria m...
EDU46501      14 FYNIGVQGRKTGITLADKGVYDEHGLEPISGIFSSPERS-----------------PPKRGGNATGS-ESMEIQES---- 71  Pyrenophora tri...
XP_016763737  20 YFDVGKVGRKTGITLQDTGIRDEHGLEPVSGIFSSPISP-------------------EQNGDRTLTsETMEVQDS---- 76  Sphaerulina mus...
EGP90627      20 YFDVGKVGRKTGITLQDTGIRDEHGLEPVSGIFSSPGEP------------------SRHNGDRTLTsEGMDLQEG---- 77  Zymoseptoria tr...

EFX05500      94 --------------------------AGPGPAALLNGQN------TA--ARLAMRQARSPAasR-SLFGSPAVRAGLNNk 138 Grosmannia clav...
Q2UBG4        77 --------------------------NAPGPADFLSDWLdwvpseNSwfTIIPKPTTGSPL--L-YARSKANKKTQEVAa 127 Aspergillus oryzae
EGE07298      76 --------------------------ADHGDVDAESSEA------EE--EQAG----KSPVpvLnTASKGKKRKESEKNl 117 Trichophyton eq...
XP_002485013  77 --------------------------DGPGPTDFLSRSAt----rRS--PFFPPPIARSPR--K-SGLSGSPRRTPALRs 121 Talaromyces sti...
XP_007777144  78 --------------------------SMPEPTEALSARQllk-gsSK--TRFPPPVARSPI--K-TSLGSSPRRQSSMGp 125 Coniosporium ap...
EKG19725      81 viddsivgalldsdeedtettlqptgSMPEPADALSARRssvrpnRA--SILPPPLGRSPI--K-TSLGSSPRRQSSMGp 155 Macrophomina ph...
CBX96946      72 --------------------------SIPEFTTAHQILRn-----PR--THLPPPRSRSPK--K-TALGSSPRRQSSMAp 115 Leptosphaeria m...
EDU46501      72 --------------------------SIPELATSHQILRn-----NR--THLPPPRARSPM--K-TALGSSPRRQSSMAp 115 Pyrenophora tri...
XP_016763737  77 --------------------------SAPDVTTTLGHRK-------T--PRLP-PARQSPL--KrTSIGGSPKRMSSVRp 118 Sphaerulina mus...
EGP90627      78 --------------------------STPDVTKTLTRRR-------T--PHLPPPRQTTPR--H-TNI-GSPKRMSSARp 118 Zymoseptoria tr...

EFX05500     139 gvaaaagdqkpkhgalrqnqllrpPSSPD-AANAppsspvKPVKRRLDF 186 Grosmannia clavigera kw1407
Q2UBG4       128 sfsd---------------sdansQSNPDeNAN-------SHEHTRDDF 154 Aspergillus oryzae
EGE07298     118 ee--------------------kgDDKPKaNHSGkgr-grKPKSRQEDh 145 Trichophyton equinum CBS 127.97
XP_002485013 122 spiv---------------qidnvSSSPTsARQrrgrvgedettsarqp 155 Talaromyces stipitatus ATCC 10500
XP_007777144 126 psq-----------------arrsANTPGrASSH------PVVSRKLDF 151 Coniosporium apollinis CBS 100218
EKG19725     156 psa-----------------mrrsSNTPNrAISQ------PTVARRLDF 181 Macrophomina phaseolina MS6
CBX96946     116 rgs------------------svgLSSPIrPAN-------LPIARRLDf 139 Leptosphaeria maculans JN3
EDU46501     116 rgs------------------saaPSSPVrAAS-------HPIARRLDF 139 Pyrenophora tritici-repentis Pt-1C-BFP
XP_016763737 119 qsrpa--------------iseepASSPRgHSE-------PAVNRKLQf 146 Sphaerulina musiva SO2202
EGP90627     119 gsrhi--------------pdedeGSSPSgNA--------PPANRRLNF 145 Zymoseptoria tritici IPO323
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