Conserved Protein Domain Family
CEP76-C2
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pfam15627: CEP76-C2 (this model, PSSM-Id:406139 is obsolete and has been replaced by 464781)
CEP76 C2 domain
Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the new C2 domain that is contained by ciliary CEP76 proteins.
Links
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Statistics
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PSSM-Id: 406139
Aligned: 22 rows
Threshold Bit Score: 122.04
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EEY68727      89 ALENDRD-VFLYLRLSTGKAFVDQlveleqdtknadqddvgldeKRCPVGSVVTFFRVNVTFQTQRQTSRDIRCCVDPPF 167 Phytophthora in...
EDV29045      70 MKIDPSK-RYLYVQMLGGRAFLEHil----------------deDRSTEKNYNGTLSIHIHFRQQRFQSRPILCACEPDL 132 Trichoplax adha...
XP_019849903 103 EAKSSKHvQCIYFQVLQGRAFVDHlt-----------------sVTELLSQDTSTFTLHVYFRHQRFQSSAVPCSCEPEF 165 Amphimedon quee...
A0BKF5        85 DRINYRS---VSLRIYKGRAFLDFi------------------------EPQNQKLQLYLSFCGQRFASATVDATVEPEF 137 Paramecium tetr...
XP_002948818  68 AELPAGK-AFLHVKLLGGRAFTDYtlri---------------------pgpEERLQLSLELFGQRFTTHEVPATAEPAF 125 Volvox carteri ...
CAM69444      92 S--DGRH--YLLVRVNGGRAFVDNl-------------------DLAPSTVSKRSVVFAAHFGNQRFRSAVKPCSAEPKF 148 Leishmania infa...
Q4D5L5        93 KLLPGEY--YLHLRLAGGKAFVDNl-------------------DLTPSFAKDYQMYVAVHFGSQRYRSNLEDVSLDPPF 151 Trypanosoma cruzi
Q384E2        93 KLLPGEY--YLHVRLAGGKAFVDNl-------------------DIAPSVAQDYHMYVALQFGPHRYRSVSQDVSVDPPF 151 Trypanosoma brucei
EFC48093      92 KKDLKKN-KILHMRLLGGNAFMEY----------------------DDNVKTDEKMICFLNYKDQRFVSQPVSCCCNPIF 148 Naegleria gruberi
ESS32622     139 DPNDP---PYLLCRFSDGHDFSEY---------------------EDESRHSGSYFVIHMSFGSQRFRSRPVEACCEPQF 194 Toxoplasma gond...

EEY68727     168 DEHFRFRVEKKrtrtartrggasyAVDVMAPWEALCLVEEPVQLNLVKV---------TKKLQSRnsngtaq-------- 230 Phytophthora in...
EDV29045     133 RDGFLLQLPQH-------------KVSARSDPTSLLSIAEPIHLLLIRN---------EPNGDKT--------------- 175 Trichoplax adha...
XP_019849903 166 KEGFLLELPKE-------------------GKDDWITSPELIHIILTRT---------HPNREGTtr------------- 204 Amphimedon quee...
A0BKF5       138 NELFLFDLRTE-------------AQKANVDLLTLSKLDHPIELCVIQI---------QNGQRK---------------- 179 Paramecium tetr...
XP_002948818 126 AGEAFFQLPTG---------------PGSVDPLQLLALRQGLHAVVMQLnplapwgsdDQAGQRD--------------- 175 Volvox carteri ...
CAM69444     149 DEEFLFEVDAT---------------GFGFGEADLIEVSTPFHIAVLRE---------DSQLNVAe-------------- 190 Leishmania infa...
Q4D5L5       152 RDEFLIDLDYK---------------SFGSCAADLIEVSTPLHIAVFRE---------ERLLTFSk-------------- 193 Trypanosoma cruzi
Q384E2       152 RDEFLIHLDYK---------------AFGTSALDLIEISTPFNLAVIRE---------DRFLSTAt-------------- 193 Trypanosoma brucei
EFC48093     149 EEDFIIDLEIEnirnv----ftdqQEDADDGVGALLQISTPIDIIILSV---------DSEGRTK--------------- 200 Naegleria gruberi
ESS32622     195 LETFAARLPTE----------------EGASYRDLLKRQLPLHLVVTKE---------DVISHSSwtkggiasnrattpr 249 Toxoplasma gond...

EEY68727     231 -----wrelsseLLAVYRMDWRRVLCSTLQLVH---FPIQL-----TGI---MKEPVGSL---------DIRADLLNCKR 285 Phytophthora in...
EDV29045     176 ------------LLSSTYLEWRKVLSSSHNRWT---TAVEL-----NGIgpeAKLSVGLL---------DLKIELIPRSl 226 Trichoplax adha...
XP_019849903 205 -----------eLVGSYLLDWRSVLASPNNKIN---KSFEL-----IGPradGRVSPGVL---------TLQWELFPHER 256 Amphimedon quee...
A0BKF5       180 ------------LFSQKLIEWRFLLCY-----GnisLNIELpttynTKMqneRKNHVGIL---------QIHLELLPKTg 233 Paramecium tetr...
XP_002948818 176 ----------------------------------------------RGAgpgKAPTAAAVantpeqvarQLSLELRPAFS 209 Volvox carteri ...
CAM69444     191 ------------LLGENIIEWRKVLKS--GYLG---LTVEL-------CgrnAGVPAGIV---------DLQLELVSKKR 237 Leishmania infa...
Q4D5L5       194 ------------MVGENIVDWRKVLRT--GYLG---LTVEL-------CgdnPGIPAGIL---------ELQLELLPNKA 240 Trypanosoma cruzi
Q384E2       194 ------------MVGENVVDWRKVLRT--GYLG---LTVEL-------CgenPGIPAGII---------ELQIEILPNKA 240 Trypanosoma brucei
EFC48093     201 ------------YIGGHRLEWRRVLKK--GVIL---MTIELg----GGSgieSKVSKGIL---------EIRLELLPRPN 250 Naegleria gruberi
ESS32622     250 esfsgntmykskILSSQKVEWQRVLHC--GKIH---TSVKL-----RGVgtrEALSVGKL---------DMEIQLLPRDE 310 Toxoplasma gond...

EEY68727     286 T 286 Phytophthora infestans T30-4
EDV29045     227 e 227 Trichoplax adhaerens
XP_019849903 257 S 257 Amphimedon queenslandica
A0BKF5       234 l 234 Paramecium tetraurelia
XP_002948818 210 A 210 Volvox carteri f. nagariensis
CAM69444     238 i 238 Leishmania infantum JPCM5
Q4D5L5       241 p 241 Trypanosoma cruzi
Q384E2       241 p 241 Trypanosoma brucei
EFC48093     251 S 251 Naegleria gruberi
ESS32622     311 T 311 Toxoplasma gondii VEG
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