Conserved Protein Domain Family
TMEM132D_N

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pfam15705: TMEM132D_N 
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.
Statistics
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PSSM-Id: 406196
Aligned: 49 rows
Threshold Bit Score: 128.9
Threshold Setting Gi: 542223953
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_022522224   41 VQYQVLNADLSFFLKEANQDIMRNSSLQARTELFFIQQ-------ARRVPTVNASYGPLSVQQPVPMEFLGpgllnnpss 113  Mexican tetra
XP_005801069   61 VQCQLSGTDSAFFLREANQEVMRNGSLSSRTEPFFLHQlep-gvaLQSQPSVNCSYGNLSIEQMIPTELLRg-------- 131  southern plat...
XP_015221913   49 VSYQITNANSFFFLKEISQDIMRNSSMQIHTEPFVILK-------TSQPPVISASYGPLSVEQTVPLHFMQ--------- 112  spotted gar
XP_002594816    7 AHLTYEHADSAYFLQDDFSSLFSNGSETVQIDQFALLR-------PREPAVVRASYGPFKVQQSVPHEFLF--------- 70   Florida lancelet
XP_008114048   34 AELKVLNGPEYFRLQRTDRYLPGNASLSSRSETFLFLHr-----qLTGKPTIQATYQPFTAQQVVPTDDSQ--------- 99   green anole
BAC33373       44 VALELLDAPEHFRVQQVGHYPPANSSLASRSETFLLMQp-----wPRAQPLLRASYPPFATQQVVPPRVTE--------- 109  house mouse
XP_007668804   60 ASLEPLDVPEFFRLQRTGHYPPANASLDSRTETFLFLRs-----rPAARPLLRASYPPFTAQQEVPGRTPE--------- 125  platypus
XP_010709076  316 VEMELQEVPEHYRLQRADGVLPANTSLHARSDTFLLLPrh---ptAGPSPLLRASYPPFSTHQ-------E--------- 376  turkey
XP_005451400   44 IKFQVLNVDHMFVRQDSPQP-SGNSSLKAQTQTFLITGpg----aGLLEPSVNASFGPLALDASIPLDLLL--------- 109  Nile tilapia
TNN74918      190 VQCQLSGADSAFFLRESNQDVMRNGSLSSRSEPFFLHQleaavaaPHSLPSVNCSYGNLSAEQPIPVELLQg-------- 261  Tanaka's snai...
XP_022522224  114 sssssssssssssvtsSTSTTP-SPQLFTFNWKVQTFIISERIHPSWPKVQVLFY------------------VVGRDWD 174  Mexican tetra
XP_005801069  132 ---------------pQPHLLT-SVSQVTMNWRIKGQVVVHKVASTRRWIQVLFY------------------LIGRRWD 177  southern plat...
XP_015221913  113 ----------------TADLFR-TSTKFTFDWKIQSYILTQKVYSSTPKMRILFY------------------ISGRDWE 157  spotted gar
XP_002594816   71 ------------------PGLNrTSPGQFYKLDIRAHLLDKSLTPEKSRLGVLFH------------------IVESDLS 114  Florida lancelet
XP_008114048  100 ------------------------STDTSVTWDVRAVSIEGTVSPYEPYTRVLFH------------------LQGQDWM 137  green anole
BAC33373      110 ------------------------PHRRPVPWDVRAVSVEAAVTPAEPYARVLFH------------------LKGQDWP 147  house mouse
XP_007668804  126 ------------------------PSGFSADWDVRAVSVEASVSPAEPQARVLFH------------------LKGQDWL 163  platypus
XP_010709076  377 ------------------------VPTKSPTWAIRAVPLHSTVSPDEPNARVLFH------------------LHGPDWR 414  turkey
XP_005451400  110 -----------------------------SGRKILPVILSRQVRSSSPVVKILFHmptesnitawqetmgsleDNGRKSN 160  Nile tilapia
TNN74918      262 ---------------pPPHLLL-STNQVTLNWKVKGQVVVPKVGSTRPWIQVLFY------------------LSGRRWD 307  Tanaka's snai...
XP_022522224  175 ---DYSTVDRLPCVRMFAFHETQEV 196  Mexican tetra
XP_005801069  178 e-pDPLPRSILPCVRALAVRDINEP 201  southern platyfish
XP_015221913  158 aqgTEGAMDDLPCVIVYAFWQTQEV 182  spotted gar
XP_002594816  115 ---RNEGSGPLPCIVLHVTMDGKEA 136  Florida lancelet
XP_008114048  138 -----SEKKPLPCVTLYVFHQAQVV 157  green anole
BAC33373      148 -----PGPGSLPCARLHATHPAGTA 167  house mouse
XP_007668804  164 -----SGHGGLPCARLHATHPAGSV 183  platypus
XP_010709076  415 grrDPPGDHSLPCIVLQAQQRSQTV 439  turkey
XP_005451400  161 ---GAKAKDGAHCVTAYAFWETREV 182  Nile tilapia
TNN74918      308 e-pDPPPQALLPCVRAVVVRDTSEA 331  Tanaka's snailfish
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