Conserved Protein Domain Family
DUF4686
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pfam15742: DUF4686 (this model, PSSM-Id:406229 is obsolete and has been replaced by 464838)
Domain of unknown function (DUF4686)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 498 and 775 amino acids in length. There is a conserved DLK sequence motif.
Links
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Statistics
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PSSM-Id: 406229
Aligned: 22 rows
Threshold Bit Score: 166.015
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Download Cn3D
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_027824331  467 PSSGEKPKY-QQQEEVQQLHQ-NLHRLQTLCSSAEKELRYERGKNLDLKQHNSLLQEESIKIKIELKQAQEKLLDSSKMC 544  sheep
XP_023356021  693 ssidkrLRYqHQGEEMQKLQQ-NLQRVQTLCSSAERELQFERTKSFDLKQHNNLLQEENIKIKAELKQAQKKLLDSTKMC 771  Tasmanian devil
6_pfamImport    1 PPSGEASPQ-QQREELQQLRQ-DFLRIQNLCSSAERELRYERGKSSDLKQHNALLQQENTKVAM--------------LC 64  
XP_007239213  256 QTTGVEVA--RLKQEVEKLKQcDMVELQKA---KERNERLDTEI-LVLRDRVRTLDTERKSLLKRLENSKIQSSNGGSTE 329  Mexican tetra
XP_005162188  731 VKAQDSLLQ-QKGEENKQLKQ-DLQRTQHLFTSAERELRYEREKNLDLKRHIALLDQEKVKLCAELKQAQAKVAQHEGNA 808  zebrafish
XP_011475217  717 IKSQDSVLS-QKAEEAKQMKQ-DLQRAQSLFTSAERELRYEKEKNMDLKRHNALLDQEKLKISAELKQAQLKLVQVEQKV 794  Japanese medaka
XP_005478310  626 ikSQDSVLK-QKTEEAKQMKQ-DLQRAQSLFTSAEKELRYEKEKNLDLKRHNTLLDQEKLKLSAELKQVQTKLVQMEQKV 703  Nile tilapia
XP_005994059  810 VKSQESLLR-QQTEEVQQFRQ-DLHRVQNLFSSAERELRYERDKNLDLKKHIALLQQENTKVNAEIKQILSKFSDQEQTS 887  coelacanth
KAE8593091    597 LLAGDTLIQ-QQHEEIRQLRQ-DLHRAQHLCSSAEKELRYERDKNLDIKKQHFCLEQANTMVSAELNQLKQKFANVTATC 674  tropical claw...
XP_023608462  301 LSSKEKLKYqQQQEEVQQLRQ-NLHRLQILCSSAEKELRYERGKNLDLKQHNSLLQEESIKLKIELKQAQQKLSDSARLC 379  little brown bat

XP_027824331  545 CS------------------------------LTAEWKHCQQKIRELELEVLKQAQSIKSQNNLQEMLAQEKSKVADAED 594  sheep
XP_023356021  772 SS------------------------------ITANWESSQQKVRDLEQEILKQSKNIQSQNSLYEKLAQEKTRVAHAEK 821  Tasmanian devil
6_pfamImport   65 GSgpnfmttpl------------dflflspflFTFPLSINKTLIKYFRPNI-------------------NKIKLLLMLI 113 
XP_007239213  330 HGsnhsvqddgndnpelldrplngseehihkrCRRESEDKDCRLRELQRRLQKQQQEHEELVERNEELEALLGEVQNKAK 409  Mexican tetra
XP_005162188  809 AG------------------------------QVAELERLQQRARDLELEMARSSQNRQTNSSLMDELNSQRSRVIAADK 858  zebrafish
XP_011475217  795 SS------------------------------QTAEIECQQQKIRELELELARTSTNHRASSSLQEDLQAERARLIAADK 844  Japanese medaka
XP_005478310  704 TG------------------------------QAAECEHQQQKIRQLELELARSSTNRSATTSLQGDLQAERARLIAADK 753  Nile tilapia
XP_005994059  888 IG------------------------------HRVELDRSQLKVKELEIEVAKLRQTTKLNKSLQEKLADERSRAIDADK 937  coelacanth
KAE8593091    675 LK------------------------------LENELEMKQQRIKEMELEVLKQTQISKVQNNWQEKLEHEKSQAHEAEK 724  tropical claw...
XP_023608462  380 SP------------------------------PPAEWKHCQQKIKELELEVLTQAESLKSQNTLKEKLAQEKSKVADAEE 429  little brown bat

XP_027824331  595 KILDLQQ-KLEHA-QKVNLTDTCILEKKQLEERIKEAIENEAKIKQQYQEEQQKRKLLDQNMNELQKQVKILQEKESLLE 672  sheep
XP_023356021  822 MVLELQK-KLEVA-SESC-TEACILDKKQLEEAIKEARKNETKLKMQYQEEQQKRKLLDQSVDELQQHIQYLHAKEALME 898  Tasmanian devil
6_pfamImport  114 KRLELQQ-NLKDSlQKFSRVEV---EKNQLMGKMKEARENEEKLKQHYQEEQQQRKFLDQTIQTLQQQIQFLRDRETLLE 189 
XP_007239213  410 EERELHEcEMEGLqRKIKNMESQLETKSHLKPEEKGVQEKESVPEIKDGGIQERLTFLENRLAEEKDWRKQL---EVDLA 486  Mexican tetra
XP_005162188  859 KVVELQQ-QLKNAlHQLRLEEARSGETSKLERDTRDMSDNLSALRAHLQEEQLQRKLLEQKDEELQQHVRSLRAKEASLV 937  zebrafish
XP_011475217  845 KVLELQQ-QLKNVqHQLRVEEARASESSRLERDSRDLSDNLSALRAQQQEQHIARKLLEQREEELQQQVRSLRLKEASLS 923  Japanese medaka
XP_005478310  754 KVLELQQ-QLKSVqHQLRVEEARAGETNRLERESRDLSDALSSLRAQQQEEHITRKLLEQREEELQQQVRSLRHKEASLT 832  Nile tilapia
XP_005994059  938 KvLELQQ-QLNAAqHQLHLLETRVQEKELLEEEVREGKENVARLRGRLQEEQLQRKLLDQNVEDLQQQIKSLRGREASIS 1016 coelacanth
KAE8593091    725 KILELQQ-QLRASqHQLQLVQSQVAERKHLEEEMKNVRENETALRTKLQEEQLKRKVLEQSCQDLKHQMGILFDKETVLT 803  tropical claw...
XP_023608462  430 KILDLQQ-KLEQA-HKVCLTDACILGKKKLEERITEEQQKR--------------KLLDQNINELQQKVKILLDKENILE 493  little brown bat

XP_027824331  673 MTSSQQQIKLQQQ-----------KAQLKELENEKRK-SDEHL----KSNQELSKKLSVLQQEKEALCEQNEHLLKQFDL 736  sheep
XP_023356021  899 QSNSKQQFKIQQQ-----------EVQLQILEDEKKL-SDEQV----KNNQELTEKISVLQQEKDSLRDEYRQFLNQLDV 962  Tasmanian devil
6_pfamImport  190 QTVVQQQLKIKEH-----------QALLQELEDEKKI-SDEHLhc-qKNRQKLSEQLSALQQEKETQHEKYSEFLNQFDA 256 
XP_007239213  487 VAQSSL-----KK-----------EKQVML-----RD-HEELK----RLRIEVQSLQAACQQEKS-----LNKSLTHIKG 535  Mexican tetra
XP_005162188  938 RTNLEISHRVQEL-----------ETRLQVMESELNTaREEQRsg-qKSCHRLEEQLLSAQHESERLQEELKLVVQQLDT 1005 zebrafish
XP_011475217  924 RTNTELSHRVQQL-----------DIRLSISETELSK-TREEVkesqKSSQKVQEELLVSQQECERLQAELQQVLLQLDA 991  Japanese medaka
XP_005478310  833 RTNAELSHRVQQL-----------DTRLSVLEAELSNaREEAKds-qASRQKLQEELLASQQDCKGLQDELQQVLLQLDV 900  Nile tilapia
XP_005994059 1017 QTNTELQLRLQQR-----------ETQLQVLENEQVTaADEHQyn-qRTSQKLSVQLSSCQLETDRLQEELQLVLQQLDT 1084 coelacanth
KAE8593091    804 RNNSALQ---HKIhqqesqllnldDVQTVS--------AKERIqi-eNTNQKLTEELLHVQQEKQQLHKEYENILKQLDE 871  tropical claw...
XP_023608462  494 MTSSQQQHRIQQQ-----------EAQLKQLENEKRK-SDEYL----KSYQELSEKVSGLQQEKEALHKEYGKFLKQLDV 557  little brown bat

XP_027824331  737 HVRNYHQKHQYYKVKLHAVKDRLVDEVELRDEKIKQLENEVGALRQQIEKEKAFQHQIATQNDTLLLEKRKLLEQVTEQ- 815  sheep
XP_023356021  963 HMRNYNEKHNHHKAKLRKAKERLTNEVEQRDERIKQLENEIEEMQRLMEKEKEFQDQVTTQNENLLIEKRRLLERLTEQ- 1041 Tasmanian devil
6_pfamImport  257 HVRYLEGQPESPRGHPGGVKYWLTKE-------------------LSHPQGEEFHSQIIAKNETLLRENWKLLDELSVQ- 316 
XP_007239213  536 EKGILEEKV----AKLERAQTRLQDN-LAEQTENSRVQEDLRENREQVTQLKVQVEQLRSEQSALEKERSTLRDELVEKr 610  Mexican tetra
XP_005162188 1006 NVRRYNEKQSQQKTKLRRAKQIFMKTVSQHEQRIQQLENDLALATSLSEKEKDWIRTVTEENEQLLLERRELLQRISEA- 1084 zebrafish
XP_011475217  992 NIRKYNEKQTQNKTKLRQAKQVFLKTTAQRDSTIQKLENDLALANSLSFKEKERIQTVVAENEKLLEDKRELLRRISEA- 1070 Japanese medaka
XP_005478310  901 HVRKYNEKQSQHKTKLRQAKQVFLKATEQRDSTIQKLENDLELASMLSQKDKERIQLVMEVNEKLLEEKRELVQKIIEA- 979  Nile tilapia
XP_005994059 1085 HIRKYNEKQTRHKAKLRRAKEVFEQEIKLRDAKNKQLESEIAITKSLSEKEQAWIKKLTTENEQLLLEKRELLQQINEQ- 1163 coelacanth
KAE8593091    872 YIRKYHEKELRHKAKLSHAKEIHINEVNQMDLYIKQLGMEIKFLKSQAEKDQQWISKITTENEHLNEEKRILLQKMNEH- 950  tropical claw...
XP_023608462  558 HVRNYNKKYYHHKTKLHRVKSRFGHEVELRDERIKLLENDIGILRQKLEKEKAFQDQVTAQNDNLLLENRKLLEQLMEQ- 636  little brown bat

XP_027824331  816 ELLIDSNKWRMSSVQNRVLF---LDEENKQLQKNCLrL 850  sheep
XP_023356021 1042 DETIQGNKWMISSVQNRVLF---LDEENKLLQENSLrL 1076 Tasmanian devil
6_pfamImport  317 EEVAKDSKLIITSIQNRVFF---LDEENKRLQEGTLrL 351 
XP_007239213  611 KEVMELQTELSIRAHERLQTegqMERLGLELQHVKEqL 648  Mexican tetra
XP_005162188 1085 EEMGNNGLRTATTTQQRVKF---LEMENKQLQEKTLtL 1119 zebrafish
XP_011475217 1071 EEMGSKGMRTASTVQHRVNI---LEVENRQLHERTMkL 1105 Japanese medaka
XP_005478310  980 EEMGSKAMKTASTVQYRVNL---LEVENKQLQDETLkL 1014 Nile tilapia
XP_005994059 1164 EEVGRTNNRTISTVQHKMHF---LEEENRQLQDRTLkL 1198 coelacanth
KAE8593091    951 EAMERNHKWDLLSAQNRAHI---LDEENRELQEGLLqL 985  tropical clawed frog
XP_023608462  637 EKLIHDDKCTISSVQHRVLF---LDKENKQLQENSLqL 671  little brown bat
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