6SYT


Conserved Protein Domain Family
SMG1

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pfam15785: SMG1 (this model, PSSM-Id:406268 is obsolete and has been replaced by 464869)
Serine/threonine-protein kinase smg-1
SMG1 is a family of eukaryotic proteins. In humans this family acts as an mRNA-surveillance protein. In C.elegans, SMG1, a phosphatidylinositol kinase-related protein kinase, is a key regulator of growth. Loss of SMG1 leads to hyperactive responses to injury and subsequent growth that continues out of control. It has an antagonistic role to mTOR signalling in these worms and possibly also in higher eukaryotes.
Statistics
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PSSM-Id: 406268
Aligned: 10 rows
Threshold Bit Score: 782.833
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6SYT_A        683 MWALSPTVFALLSKNLMIVHSDLAVHFPAIQYAVLYTLYSHCTRHDHFISSSLSSSSPS------LFDGAVI-STVTTAT 755 
XP_414907     630 MWALSPTVFALLSKNLMIVHGDIAVHFPAVQYAVLYTLYSHCSRHDHFISSSLSSSSPS------LFDGAVI-STVTTAT 702  chicken
XP_009297729  622 MWALSPTVFALLSQNLVIVHSDLAVHHPAVQYAVLYTLYSHCTRHDHFISSSLSSSSPS------LFDGAVI-STVTTAT 694  zebrafish
XP_001947123  600 MWALQPSIFELLSTKL---DPTIIKMNDPLRFSLMFLLYSHCKKHNNFVASSRLVTAGR------TSEKSQQnVEINSHK 670  pea aphid
XP_016845620  747 MWALKPSILELLAVKLRPHDPLLSVESPLLQYHILFLLFTHCSRYNHFVPSSSLITGTSscrpldIFPGTLE-VPTVSPT 825  jewel wasp
EDX17288      581 MYACKPSILELLLTNCRAHELKLWGRYPAAQQAIFSLLVVHCQANHNFRTNSSL-----------LRDQELS-AENTSPT 648  Drosophila si...
XP_001963716  557 MYACKPSILELLLTNCRAQDLALWSRYPSTHQAIINLLVVHCQANHNFRTNSSL-----------LRDQEQPlSENTSPT 625  Drosophila an...
XP_002067384  603 MYACKPSILELLIRNCRADDLALWSRYPGTYEAILNLLATHCQANHNFRTTSSL-----------LRDGNIQnPEHTSPT 671  Drosophila wi...
Q29I80        480 MYACQPSILKLLISNCRAQDLCLWARYPTTHQALLGLLVVHCQANHNFRTNSIL-----------FRDPGLS-TENTSPT 547  Drosophila ps...
EKC30990      623 MWALSPSIFDLASKHFSPLDEVVSEVYPAVQYALLNTLYSHCSRHGNFVSSSSLIMQTT------RLDGSLM-ANVNPTT 695  Pacific oyster
6SYT_A        756 KKHFSIILNLLGILLKKD-NLNQDTRKLLMTWALEaavLMr---KSETYAP-LFSLPSFHKFCKGLLANTLVEDVNICLQ 830 
XP_414907     703 KKHFSIILNLLGLLLKKD-NLTQDTRKLLMTWALE---VAvlmkKSETYAP-LFSLPSFHKFCKGLLANTLLEDVNICLQ 777  chicken
XP_009297729  695 KRHFSTLLNLLGMLLSKD-HLNPEARRLLLTWSLE---VAlmmkKSETYAP-LFSLPSFLKFCKGLLANSLNEDTTICLQ 769  zebrafish
XP_001947123  671 SGNLVKILNIFEKYLKR--NVNVDCKLLVLKWIYE---Llm-haDSASYLNiILLSPEMINIVRSLIYVALKRNEILLFD 744  pea aphid
XP_016845620  826 SGHLSIILNLIAKTIENK-RAPDQTLLLLLDWIQE---IYl---QAENYIGvLSKTEECQTVVSSLLVCGATTNHKVSMA 898  jewel wasp
EDX17288      649 ANNFASILRFLDSVLGQAhQLTPQNLRVLLQWVEml------lrECREKSDlLMEQENFRGICCNIAATASKLT---PVE 719  Drosophila si...
XP_001963716  626 ANNFATILRFLAAVLENAgLLNPQNLRQLLQWLQvl------lnECRDRCDlLLDQEQFLSICRSLVTTACKWS---PQE 696  Drosophila an...
XP_002067384  672 AQSFETIIGFLARNLEHSlQLTQQNLKLLLRWTHsl------ldECRERAStLLEQPDFMSICRSVAQIATKWG---LLE 742  Drosophila wi...
Q29I80        548 AHSFEYIIRFLDSILTKAgRLAAENLKLLLQWTQll------ltECRERAPlLLEQDGFLGICYSVGGAAAKWR---PLE 618  Drosophila ps...
EKC30990      696 ANNFTQILRLLAGLLSQV-HASYDSRCLGLKWIAD---II----GSLQTNPqIFYSEEFTNVIRYITQLGHNSDFQISMS 767  Pacific oyster
6SYT_A        831 ACSSLHALSSSLP------DDLLQRCVDVCRVQLV-HSGTRIRQAFGKLLKSIPLDVVLS-----------------NNN 886 
XP_414907     778 ACSSLHALSSSLP------DDLLQRCVDVCRVQLV-HSGARVRQTFGKLLKSIPLDVVLS-----------------NRN 833  chicken
XP_009297729  770 ACNSLQVLSSSLT------MELLQRCVDVCRVQLV-HSAVRVRQAFGKLLRSVPMHVALS-----------------AHS 825  zebrafish
XP_001947123  745 GIAQILNIVLGNPtfcqskPLIVVDILDLCLSCIN-LTEHDISKQFYALIHKISLITVLQnvsicslknkskfnkkiNQM 823  pea aphid
XP_016845620  899 VCKNIESLLKAKQvs--wsEEIYSNIVDLATLHLT-SLDKTVRETYGHLLMNIPLNIVIPklnkagllsddkkfrniQNY 975  jewel wasp
EDX17288      720 SAACIQTVLDYGLerlakyPQLLILYRDTALQQLQ-MVSTNCHAPYFQIYAQLPLHLTLTgceslmpgmtsrrvsvwQQR 798  Drosophila si...
XP_001963716  697 SAACIQIVLDYGPekqehlLELLTLYRDMALQQLQ-VLSPNGHTPFSQIYAKLPLRITLTggdtpipgmssrrvcvwQQR 775  Drosophila an...
XP_002067384  743 AAACIQSVLGYGLts--qqDPLLLLYRDAALQQIKwILASNQLTVFAQIYAQLPLHVTLFaggvps-----priclwQQK 815  Drosophila wi...
Q29I80        619 SAACMQAVLDFGPqalhtkQDLLVLYRDTALQQLQ-VLTTSGHAPYAQIYAQLPLHMTLFesglqg-----rrvcvwQQK 692  Drosophila ps...
EKC30990      768 VCRCLQDVYKINSnl---pINLIQSAVKLSVYKLS-DVRPEVRDGYLSLLRVLPANVTTRlysllhlggdndqsisvQEG 843  Pacific oyster
6SYT_A        887 HTEIQEIslalrsHMSKAPSNTFHPQDFSDVISFILYGNSH-RTGKDNWLERLFYSCqrldkRDq---------sTIPRN 956 
XP_414907     834 HTEIQEIslairsHMSKAPSNTFHPQDFSDVISFILYGSTH-RTGKDNWLERLFYSCqrldkRDq---------pTIPRN 903  chicken
XP_009297729  826 HSEIKEIslairrHMSKVPSNTFHPQDFSDLIGFILYGTVH-RGGKEPWLERLYHSCqrlekKDs---------aMVPRA 895  zebrafish
XP_001947123  824 MSS----------HMRRKAVVTLKTEYFKNYMCEMIEPNTNnNDSTTHWLLDVVNSCsfdidSGe---------tELLSH 884  pea aphid
XP_016845620  976 SCE--SLilaqrlHMR-SNNGEMQAQHFKTYMAFLLQEYYFdAFG----LSEVFTLCwptisDNet-------maKMYEL 1041 jewel wasp
EDX17288      799 ISQWSAV----------------RDTVFRDFFERVQKPE---QESLVHCLRELFVRScqvapQDer-------qmNLSQC 852  Drosophila si...
XP_001963716  776 MSQCSAV----------------RDSVFRDFFERLQHPE---QQPLTNSLRDLFVRScqvapQDer-------qeKLSQC 829  Drosophila an...
XP_002067384  816 ISQCSSV----------------RDTVFREFFEHLQQSE---QQQLNQSLRDLFVRScqisaMDer-------qeMLSHC 869  Drosophila wi...
Q29I80        693 MSQCSAV----------------RDNVFQQFVDHLQRPE---QEQLTQCLRELFVRSyqvapPDer-------qeKLSQC 746  Drosophila ps...
EKC30990      844 AEGVTAAwlarraHINRIPNGEFHAVNFRQIMAYILHDTSPiQSGSWNWLEAMFYSC-----QDathdhkmietfRMSNF 918  Pacific oyster
6SYT_A        957 LLKTDAVLWQWAIWEAAQFTVLSKLRTPLGRAQDTFQTIEGIIRSLAAHTLNPDQDVSQWTt-----ADNDEGHGNNQLR 1031
XP_414907     904 LLKTDAVLWQWAVWEAAQFTVLSKLRTPLGRAQDTFQTIEGIIRSLAAHTLNPDQDVSQWTt-----ADNDEGHSSNQLR 978  chicken
XP_009297729  896 LLKTEAVLWQWAVWEAAQFTVLSKLRTPLGRAQDTFQTIEGMIRSLAAHSLNTEQELSQWSg-----GESDEGHHTNQLR 970  zebrafish
XP_001947123  885 AQHCRVFLYFWINWEAANFCVINRLRTPFGKPNSTFRAIEGGIKMWARD--------SISAlndetkVKHTEGKLNNLRY 956  pea aphid
XP_016845620 1042 ALANRTFLFFWGGFEAAQHCVLNKLRTPLGKPQETFTTIEGALKTLAREISC-----TAEIpkkdkrG--LDYLLHEHTR 1114 jewel wasp
EDX17288      853 TKRCQRLATAWLQFEAARYCVEQRLRTTLGKPQDTFFGFEAIIMRHARLLSGCAKEMERSAm----dTLSLEELLNMQSN 928  Drosophila si...
XP_001963716  830 TRRCQRLATAWMQFEAARYCVDQRLRTTLGKPQETFLGFEAIIMRHARQLSGCGKEEERAAl----dTLTLEELSNMQSN 905  Drosophila an...
XP_002067384  870 IRRCQRLAAAWMQFEAARYCVDQKLRTTLGKPQDTFLGFEAIIMRHARMLSGCAKEAERIDp----dGLSLMQLSNMQMN 945  Drosophila wi...
Q29I80        747 TRRCQRLSAAWLQFEAARYCVDQRLRTTLGKPQETFLGFEAVIMRHARLLSGCAKEVERSSl----dGLSLEQLSAIQVN 822  Drosophila ps...
EKC30990      919 VDNNEAMLWFWATWESAQYCVLNRLRTPLGKPQETFTSIEGVLKMFAKELDKPAEERNDISktdqkkGGAKSSDLSSHLR 998  Pacific oyster
6SYT_A       1032 LVLLLQYLENLEKLMYNAYEGCANALTSPPKVIRTFFYTNRQTCQDWLTRIRLSIMRVGLLAGQPAVTVRHGFDLLTEMK 1111
XP_414907     979 LVLLLQYLENLEKLMYNAYEGCANALTSPPKVIRTFFYTNRQTCQDWLTRIRLSIMRVGLLAGQPAVTVRHGFDLLTEMK 1058 chicken
XP_009297729  971 LALLLQFLENLEKLMYNAYEGCASALTAPPKGIRTFFYTNRQTCQDWLTRIRLALMRVGLLSGQPAVTVRHGFDLLTEIK 1050 zebrafish
XP_001947123  957 TRNLVAFIECLEKSVCNAIDGTATALPTAQKPVRHFFHTNRNTCYEWNSTIRSAMLAVALNSGLSSSAIRHGQYLVHHLT 1036 pea aphid
XP_016845620 1115 VRQLVEFLEHLERVIHNAAEGCAVALLPHSKPVRTFFHTNRSTCKEWLNRIRLALCVVSLHAGLATNALRNGQRLLEDLC 1194 jewel wasp
EDX17288      929 LSLLLGFLDVLEKLIYNAAEGSAFALRPPPKPVAAFFRLNNPTCQSWFNRIRIGVVIIAMHVQQPELVIRYAQQILV--- 1005 Drosophila si...
XP_001963716  906 LVLMLGFLDALEKLIYNAAEGSAFALRPPEKPVAAFFRLNNPTCQSWFNRIRIGVVIIAVHVQQPELVIRYAQKILL--- 982  Drosophila an...
XP_002067384  946 LNMLLGFLDALEKLIYNAAEGTAFALRAPEKPVSAFFRLNNPTCQSWFNRIRIGVVIIAMHSQQPELVIRYAQQILV--- 1022 Drosophila wi...
Q29I80        823 LGMLLGFLDALEKLIYNAAEGSAFALRPPEKPVAAFFRLNNPTCQSWFNRIRIGVVITAMHIQQPELVIRYAQQILV--- 899  Drosophila ps...
EKC30990      999 VHLLLQFMEHLEKLLYNAYEGCAVSMPMSPKTVRTFFRTNKGTCLEWLSRVRSSVIKIALHSGMPAMAIRQCHQLLQEMK 1078 Pacific oyster
6SYT_A       1112 -TTSLSQGNELEVTIMMVVEALCELHCPEAIQGIAVWSSSIVG--KNLLWINSVAQQAEGRFEKASVEYQEHLCAMTGVd 1188
XP_414907    1059 tNNSLSQGNELEVTIMMLVEALCELHCPEAIQGIAVWSSAVVG--KSLTWINSVAQQAEGRFEKATAEYQEHLCAMTGVd 1136 chicken
XP_009297729 1051 --NSSTQGPEMEVPVTMLVEALCELRCPEAIQGLAAWSLANTG--KSMGWLSSVALQAEGKFEKAALEYQEQLCAVTGMd 1126 zebrafish
XP_001947123 1037 -KQSEFPVKEFILAIIQLAWAYSKLKESDCIRGLYVWSKEVAH--LKLPFLNILADQASGKFEEAAESYMNLLTTnsd-- 1111 pea aphid
XP_016845620 1195 -TANNTQGAEFERATLCTARAMVMLGEAEALQGLYVYCKEK-D--RKFVWLKAAMEEAAGKYELAAENYRRILEDQILT- 1269 jewel wasp
EDX17288     1006 --NPQTQDPTYSQAIVYMAWALISCQESDSLRGLRLWASSKSS--KSYKWLKYAADQAAGKRESALAGYKTILAEKEQQ- 1080 Drosophila si...
XP_001963716  983 --TQKAQDATYSQAIVYLAWAWVCCQESDSLRGLYLWARSKSS--KSFQWLQCAADQAGGRKDAALAGYRSLLNETEEQp 1058 Drosophila an...
XP_002067384 1023 --TQNPQDCSFSQAIVYLAWAWICCQEADSLRGLYLWARCKVSg-KTFQWLHCAADQAAGRKETALSGYSQILAEDD--- 1096 Drosophila wi...
Q29I80        900 --TQKTQDATYSQALVYLAWAWISCQEADSLRGLYVWARAKSSsgKSYQWLQHAAEQAAGRREAALSGYQNVLAEEGQR- 976  Drosophila ps...
EKC30990     1079 -DNNTLQGYDFEQTVLFLVKALVELKEGDAIMGVYNWCKEQTG--KKFLWIKALVEKATGKYESAAKELKNVLKVMVSSd 1155 Pacific oyster
6SYT_A       1189 CCISSFDKS-----------------VLtlanagrnsaspkhslngesrkT------VLSKPTDSSPE-------VIN-Y 1237
XP_414907    1137 CCISGFDKTvlklansnsvnnaspkhSL----------------------NgetrktVLTKPSDCSPE-------VIN-Y 1186 chicken
XP_009297729 1127 CSIKVFDRSllkltgt---ntsspkhTS----------------------SgegrktVLLKSSECSPE-------VLN-F 1173 zebrafish
XP_001947123 1112 ------------------------------------------------------qiiIYLKGGGGSINniegpleVLQkF 1137 pea aphid
XP_016845620 1270 -----RSKDdskal-------eirckNE----------------------G---------GDSQ-----------VAV-F 1294 jewel wasp
EDX17288     1081 SELEPHTRQ----------------------------------------------------------------------F 1090 Drosophila si...
XP_001963716 1059 PELDTHTRQ----------------------------------------------------------------------F 1068 Drosophila an...
XP_002067384 1097 AELEPHTRQ----------------------------------------------------------------------F 1106 Drosophila wi...
Q29I80        977 QELEPHTHQ----------------------------------------------------------------------F 986  Drosophila ps...
EKC30990     1156 SEKADSPRDdlskve-----mimpkkIT----------------------G------ILSKQSPFPPPdsnipvlKVH-F 1201 Pacific oyster
6SYT_A       1238 LGNKACECYISIADWAAVQEWQNAIHDLKKS--TSSTSLNLKADF------NYIKSLSSFESGKF 1294
XP_414907    1187 LGNKACECYISIADWSAVQEWQNMVHDLKKS--TSNTSINLKADF------NYIKSLSSFESGEL 1243 chicken
XP_009297729 1174 LANKACECYVALSDWESVQEWQASMMNLKKN--SSSSSVNLKTDF------NYIRAMSRFEEGDF 1230 zebrafish
XP_001947123 1138 IIEQLKECYMSICDWKPLMDWSQNEENLIPSi-AKDKYFWQNRYVs----aNDLQIVNDVEEGny 1197 pea aphid
XP_016845620 1295 CMDHLCKCFRSVGDWKQLEAWKQREAEILDQ----DKNLCLRRQMleniapQQATCLRKFEEAEe 1355 jewel wasp
EDX17288     1091 VVAQMMQCLQDLGQWSQLVELKQQHMMRPED--RELNPFLQRSNVev---nALERLLARGQEACS 1150 Drosophila simulans
XP_001963716 1069 VVAQMMQCLQDTGQWSQLVELKQRQLTRPED--SERNPFLQQSNVev---sALERLLAKSEEQSA 1128 Drosophila ananassae
XP_002067384 1107 VIAQKMQCLQDLGRWSRLVELKQKHLNRPED--SELNPFLQRSNVev---sALEKLLAKSEELSS 1166 Drosophila willistoni
Q29I80        987 VLAQMMQCLQDTGQWSQLVDLKQHKLLRPED--KELNSFLQCRNVdv---sAFERLLARTESNSn 1046 Drosophila pseudoobscura
EKC30990     1202 VVTEIFDCYEKLYDWESVMEWQENVLQYRQDysHLQAAFNSDVDL------NYIRALSAFEDGDF 1260 Pacific oyster
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