Conserved Protein Domain Family
UPAR_LY6_2
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pfam16975: UPAR_LY6_2 (this model, PSSM-Id:407185 is obsolete and has been replaced by 435685)
Ly6/PLAUR domain-containing protein 6, Lypd6
UPAR_LY6_2 is a family of higher eukaryotic proteins expressed in neurons. It modulates nicotinic acetylcholine receptors by selectively increasing Ca2+-influx through this ion channel. The family carries an LU protein domain - about 80 amino acids long characterized by a conserved pattern of 10 cysteine residues. The family is a positive feedback regulator of Wnt/beta-catenin signalling, eg for patterning of the mesoderm and neuroectoderm in zebrafish gastrulation, where Lypd6 is GPI-anchored to the plasma-membrane and interacts with the Wnt receptor Frizzled8 and the co-receptor Lrp6.
Links
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Statistics
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PSSM-Id: 407185
Aligned: 18 rows
Threshold Bit Score: 163.323
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_006003854  40 TPFLYSFKCFTCDSAPDNYNCNRWAEDKWCPQDTDYCLTIHHFTSHGKSKSVTKRCAKKEECHFVGChhHHHRDFGHTEC 119 coelacanth
XP_008116044  41 TPYPGGFKCFTCEQAVDNYECNQWAPDIYCPRVTRYCYTQHTLEANGKSVSVTKRCVPLEDCLATGC--IDLQHKGLRVC 118 green anole
XP_013053574  41 TPFPHGFKCFTCEKAADNYECNRWAPDVYCPRGTRYCFSQHMMKVTGESVSVTKRCVPLEDCLSTGC--TYVKHEEYKVC 118 Anser cygnoides...
XP_006003864  41 TPYPGGFKCFTCENASDNYECNRWAPDVYCPRGTKYCYTQHRMDSNGMSISVTKQCMSLEGCMSTGC--SETKLEGHKVC 118 coelacanth
XP_003440959  41 TPYPGGFKCFTCQDAVDNYDCNRWAPDVYCPKDTKYCSTLHMMDRSGESVSVTKRCATMEECLFTGC--ADVADTGYQVC 118 Nile tilapia
XP_017213169  35 TPYPKSFKCFTCEQASDNYSCNRWAEDVWCPQNTQYCMTIHHFNHHGKTKFVTKRCAVRDECRLAGC--RHHKNT-HHEC 111 zebrafish
XP_015214002  42 TPFPSSFKCFTCDRAADNYDCNRWAEDKWCPQHTQYCLTVHHFGSRGRSRWVTKKCAAREECQAVGC--RHHTSTGHTEC 119 spotted gar
Q66IA6        41 TPYPGGFKCFTCEDAPDNYECNRWAPDLYCPRESRYCYTHHKMSWDGNTVSVTKRCVPLEDCLQTGC--SDIDHEGNRVC 118 zebrafish
AFJ71300      41 TPYPGGFKCFTCEKAADNYECNRWAPDIYCPRETRYCYTQHTMEVTGNSISVTKRCVPLEECLSTGC--RDSEHEGHKVC 118 Rhesus monkey
AAI54707      41 TPYPGGFKCFTCEKAADNYDCNRWAPDIFCPRETRYCYTQHIMNATGESVSVTKRCAALEHCLNSGC--RDSINKDQKVC 118 tropical clawed...

XP_006003854 120 TSCCEGMICNVdvptNHTNAVFAVIQS 146 coelacanth
XP_008116044 119 TSCCEGNICNLplprNASDAIFATTTP 145 green anole
XP_013053574 119 TSCCEGSICNLplprNTTDAVFTTLSP 145 Anser cygnoides domesticus
XP_006003864 119 TSCCEGNICNLplpwNASDAIFATISP 145 coelacanth
XP_003440959 119 SSCCEGNICNVlvprNDSSAIFSSISP 145 Nile tilapia
XP_017213169 112 VSCCEGMVCNVelptNHSNAVFAQRRA 138 zebrafish
XP_015214002 120 VSCCEGMACNVevptNRTNAVFAMMKS 146 spotted gar
Q66IA6       119 TACCEGNICNLplprNETDAIFSTTSP 145 zebrafish
AFJ71300     119 TSCCEGNICNLplprNETDATFATTSP 145 Rhesus monkey
AAI54707     119 TSCCEGNICNLplprNETDAIFATTSP 145 tropical clawed frog
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