Conserved Protein Domain Family
Tiam_CC_Ex

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pfam18385: Tiam_CC_Ex 
T-lymphoma invasion and metastasis CC-Ex domain
This is the CC and Ex subdomains found in PH-CC-Ex globular domain from Tiam1 and Tiam2 proteins (T-lymphoma invasion and metastasis). The CC subdomain forms an antiparallel coiled coil with two long alpha-helices, together with the C-terminal Ex subdomain they form a small globular domain comprising three alpha-helices. The CC subdomain of the Tiam2 PHCCEx domain follows the C-terminal alpha1 helix of the PH pfam00169 subdomain through a four-residue linker.
Links
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Statistics
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PSSM-Id: 408184
Aligned: 2 rows
Threshold Bit Score: 195.744
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1_pfamImport  1 QKIDMDEKMKKMGEMQLSSVTDAKKKKTILDQVFLWGENTEQERLSLFLFAQYLAECQGAELPCPTYMLIYASETDKLAS 80 
2_pfamImport  1 QKIDMDEKMKKMGEMQLSSVTDAKKKKTILDQVFLWGENTEQERLSLFLFAQYLAECQGAELPCPTYMLIYASETDKLAS 80 
1_pfamImport 81 GTLGVARVGTYQSQVAAR 98 
2_pfamImport 81 GTLGVARVGTYQSQVAAR 98 
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