2PBD


Conserved Protein Domain Family
WH2_hVASP-like

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cd22185: WH2_hVASP-like 
Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins
This family contains the Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of Ena/VASP family members including Protein enabled homolog (also known as Mena, mammalian enabled), VASP (vasodilator-stimulated phosphoprotein) and EVL (Ena-VASP-like or Enabled VASP or Ena/VASP). These are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells, platelet activation and cell migration. Ena/VASP proteins processively elongate F-actin barbed ends, promoting dissociation of barbed end assembly antagonists (uncapping). WH2 domains are small, widespread intrinsically disordered actin-binding peptides displaying significant sequence variability and different regulations of actin self-assembly in motile and morphogenetic processes. WH2 domains are identified by a central consensus actin-binding motif LKKT/V flanked by variable N-terminal and C-terminal extensions.
Statistics
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PSSM-Id: 409225
Aligned: 6 rows
Threshold Bit Score: 29.9483
Created: 14-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
actin-bindingactin-binding
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:actin-binding motif [polypeptide binding site]
Evidence:
  • Structure:2PBD: human VASP WH2 domain binds actin, contacts at 4A
    View structure with Cn3D
  • Comment:WH2 domain binding surface for actin

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            ## ##  # #####      
2PBD_V     17 GGAGAPGLAAAIAgAKLRKVSKQEEAS 43  human
ELW71117  363 GGTGAPGLAAAIAgAKLRKVSKQEEAS 389
P50552    219 GGAGAPGLAAAIAgAKLRKVSKQEEAS 245 human
Q9UI08    216 DESSMSGLAAAIAgAKLRRVQRPEDAS 242 human
Q8N8S7    385 DNRPLTGLAAAIAgAKLRKVSRMEDTS 411 human
CAA67108  215 GGSGAPGLAAAIAgAKLRKVSKQEEAS 241

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