1DIP


Conserved Protein Domain Family
ZIP_TSC22D3

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cd21940: ZIP_TSC22D3 
Click on image for an interactive view with Cn3D
leucine zipper domain found in TSC22 domain family protein 3
TSC22 domain family protein 3 (TSC22D3) is also called DSIP-immunoreactive peptide, protein DIP, delta sleep-inducing peptide immunoreactor, glucocorticoid-induced leucine zipper protein (GILZ), TSC-22-like protein, or TSC-22-related protein (TSC-22R). It protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, it plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, it inhibits anti-CD3-induced NFKB1 nuclear translocation. TSC22D3 contains a leucine zipper motif, a Pro/Glu rich domain, and three potential phosphorylation sites. This model corresponds to the leucine zipper (ZIP) domain. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.
Statistics
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PSSM-Id: 409280
View PSSM: cd21940
Aligned: 6 rows
Threshold Bit Score: 105.419
Threshold Setting Gi: 253722140
Created: 20-May-2020
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
dimer interface
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:leucine zippers form homo- or heterodimers with other leucine zippers
  • Structure:1DIP; Sus scrofa TSC22D1 forms a homodimer, contacts at 4A
    View structure with Cn3D
  • Citation:PMID 8375381
  • Citation:PMID 9388238

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      ###  #  ##  ## ##  ## ##  ##  #   ##                              
1DIP_A         1 XMDLVKNHLMYAVREEVEILKEQIRELVEKNSQLERENTLLKTLASPEQLEKFQSRLSPEepapetp---------eape 71  pig
NP_956863     57 AMDLVKNHLMYAVREEVEILKEQIKELAEKNNQLERENSLLKNLASPEQLEKFQSRLPSDsslpldpqelgspengdhqy 136 zebrafish
XP_005992935  57 AMDLVKNHLMYAVREEVEVLKEQIKELVEKNSQLERENSLLKTLASPEQLQKFQSHLPLEtttpekqpc----apaqpsp 132 coelacanth
NP_001070702  57 AMDLVKNHLMYAVREEVEVLKEQIKELLEKNSQLERENSLLKTLASPEQLEKFQSRLPSEvlhpqeqsp----gaappaq 132 chicken
NP_001120079  57 AMDLVKNHLMYAVREEVEVLKEQIKELVEKNSQLEKENHLLKNLASPEQMKKFQSRLPQDetpiktkl------dflras 130 tropical clawed...
Q99576        57 AMDLVKNHLMYAVREEVEILKEQIRELVEKNSQLERENTLLKTLASPEQLEKFQSCLSPEepapesp---------qvpe 127 human
Feature 1               
1DIP_A        72 apGGSAV 78  pig
NP_956863    137 ssTGSAV 143 zebrafish
XP_005992935 133 htGGSAV 139 coelacanth
NP_001070702 133 hsGGSAV 139 chicken
NP_001120079 131 qkAGSAV 137 tropical clawed frog
Q99576       128 apGGSAV 134 human

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