Conserved Protein Domain Family
Ig_CSPGs_LP_like

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cd05714: Ig_CSPGs_LP_like 
Immunoglobulin (Ig)-like domain of chondroitin sulfate proteoglycans (CSPGs), human cartilage link protein (LP), and similar domains
The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in chondroitin sulfate proteoglycans (CSPGs) and human cartilage link protein (LP). Included in this group are the CSPGs aggrecan, versican, and neurocan. In CSPGs, this Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggrecan and versican have a wide distribution in connective tissue and extracellular matrices. Neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. There is considerable evidence that HA-binding CSPGs are involved in developmental processes in the central nervous system. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.
Statistics
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PSSM-Id: 409379
Aligned: 3 rows
Threshold Bit Score: 199.744
Created: 4-Sep-2007
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:Ig strand A [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1      ####                                                                            
P13611      26 VGKSPPVRGSLSGKVSLPCHFstmptlppsyntsefLRIKWSKIevdkngkdlKETTVLVAqngnikiGQDYkg-rVSVP 104  human
O14594      41 KLGSGSVQAALAELVALPCLFtlqprp---saardaPRIKWTKVrtas--gqrQDLPILVAkdnvvrvAKSWqg-rVSLP 114  human
P10915      43 EAEQAKVFSHRGGNVTLPCKFyrdptaf--gsgihkIRIKWTKLtsd----ylKEVDVFVSmg---yhKKTYggyqGRVF 113  human
Feature 1                                                      
P13611     105 THPEAVGDASLTVVKLLASDAGLYRCDVMYGIEDTQDTVSLTVDGVVF 152  human
O14594     115 SYPRRRANATLLLGPLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVVF 162  human
P10915     114 LKGGSDSDASLVITDLTLEDYGRYKCEVIEGLEDDTVVVALDLQGVVF 161  human

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