1JOW,1BU2,1F5Q,1G3N


Conserved Protein Domain Family
CYCLIN_vCyC_rpt1

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cd20517: CYCLIN_vCyC_rpt1 
Click on image for an interactive view with Cn3D
first cyclin box found in viral cyclin (v-cyclin)
v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.
Statistics
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PSSM-Id: 410221
Aligned: 6 rows
Threshold Bit Score: 146.938
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
CDK interface
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:CDK interface [polypeptide binding site]
Evidence:
  • Structure:1JOW; Saimiriine gammaherpesvirus 2 v-Cyclin in complex with human CDK6, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                           #                                     ##### # ##          
1JOW_A     47 VTVDNRTILLTWMHLLCESFElDKSVFPLSVSILDRYLCKKQgtKKTLQKIGAACVLIGSKIRTVKPMTVSKLTYLSCDC 126 Saimiriine alphahe...
1BU2_A     26 VTVDNRTILLTWMHLLCESFElDKSVFPLSVSILDRYLCKKQgtKKTLQKIGAACVLIGSKIRTVKPMTVSKLTYLSCDC 105 Saimiriine herpesv...
1F5Q_B     44 FTSQYRKVLTTWMFCVCKDLRqDNNVFPLAVALLDELFLSTRidRENYQSTAAVALHIAGKVRAYMPIKATQLAYLCGGA 123 MuHV-4
1G3N_C     46 LTSHMRKLLGTWMFSVCQEYNlEPNVVALALNLLDRLLLIKQvsKEHFQKTGSACLLVASKLRSLTPISTSSLCYAAADS 125 Kaposi's sarcoma-a...
Q01043     47 VTVDNRTILLTWMHLLCESFElDKSVFPLSVSILDRYLCKKQgtKKTLQKIGAACVLIGSKIRTVKPMTVSKLTYLSCDC 126 Herpesvirus saimir...
Q77Q36     46 LTSHMRKLLGTWMFSVCQEYNlEPNVVALALNLLDRLLLIKQvsKEHFQKTGSACLLVASKLRSLTPISTSSLCYAAADS 125 Human herpesvirus ...
Feature 1           #  ##  #   ##
1JOW_A    127 FTNLELINQEKDILEALKW 145 Saimiriine alphaherpesvirus 1
1BU2_A    106 FTNLELINQEKDILEALKW 124 Saimiriine herpesvirus 2
1F5Q_B    124 TTADKLLTLEVKSLDTLSW 142 MuHV-4
1G3N_C    126 FSRQELIDQEKELLEKLAW 144 Kaposi's sarcoma-associated herpesvirus - Human herpesvirus 8
Q01043    127 FTNLELINQEKDILEALKW 145 Herpesvirus saimiri (strain 11)
Q77Q36    126 FSRQELIDQEKELLEKLAW 144 Human herpesvirus 8 strain GK18

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