4A04,5T1J,4S0H,1H6F,1XBR


Conserved Protein Domain Family
T-box

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cd00182: T-box 
Click on image for an interactive view with Cn3D
DNA-binding domain of the T-box transcription factor family
The T-box family is an ancient family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the family is Brachyury (also known as TBXT, or T). Members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns. The T-box factors in Caenorhabditis elegans have evolved very differently than those in other organisms; its genome contains 22 T-box genes which encode factors which are diverse in DNA-binding specificity, function and sequence, and only 3 of these factors fall into the conserved T-box subfamilies.
Statistics
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PSSM-Id: 410312
Aligned: 153 rows
Threshold Bit Score: 124.628
Threshold Setting Gi: 30913390
Created: 1-Nov-2000
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA binding
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:T-box monomers dimerize upon DNA binding; some form weak dimers, others tight dimers, some may bind as non-associating monomers where the dimer is kept in register by the DNA
  • Structure:4A04; Homo sapiens TBX1 monomer binds DNA, contacts at 4A.
    View structure with Cn3D
  • Structure:5T1J; Mus musculus TBX21 monomer binds DNA, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                   ##                                #               
4A04_A     16 VSVQLEm--KALWDEFNQlgTEMIVTKa-GRRMFPTFQVKLFGMDPmADYMLLMDFVPvddkRYRYAFh--sSSWLVAGK 90  human
Q9NA56      7 FNVTMAe--EDRWKQWYPn-MEMIVNNkgPKLIFPELNFNITGLEEkSRYVVLLSIEKydniRYGYRN----GKWGPSKV 79  Caenorhabditis ele...
NP_508304  15 IQVNVIg--SSRTSDDHF--LEQMLTKrkKTNISQDLHYTLLGLNPrDLYQISIKLARidekKYKFNGnfngGDYYPHKN 90  Caenorhabditis ele...
POM34953  123 VEVEFQd--EHLWRQPEQi-MEMIANKe-GTPISPGIAFLVNGLDVdAKYEVKLSMERvdfeRYTYTD----GEWQISTK 194 Caenorhabditis rem...
Q9N2K7      7 IVVKMSn--EELWKERYPn-MEMISNSkrITPIFPEIKFKISGLEEnSRYVLVLSLEKmdniRYGINEn---KEWAPSSA 80  Caenorhabditis ele...
OZG18313    4 INAALTpecQKIWAQRQGs-MEMVSKGakGTPLFPGLKFMVDGMEEkSNYSISLTLERldstRLTFKN----GVWARSEV 78  Caenorhabditis latens
Q9NAH2      1 MQVSIVn--EHKYRELEPl-NEMLVKRg-GVKMIPEPKFVISGLVDnEEYVIKLRIDLadefRYSYQN----QQWTPFAP 72  Caenorhabditis ele...
EGT34759    3 MQVFVVd--EQKYREFEPi-NEMLVKRg-GVKMHPEPQFMIRGLSPdEEYILKLRIEMvdelRYIYQT----DQWIPISS 74  Caenorhabditis bre...
EGT40516    9 IEVSIDekhDVLWKKFHSmpHEMMLNKv-GRMFFPRLEYDIKGLVPsKSYAMALHIELaskeHYFFRN----DNWVKEGK 83  Caenorhabditis bre...
POM52008    9 IAVSMVd--DVFWRQCYNltNEIKLQYt-RGLVSPSLSYKVSGLDPkKNYSMTVRFEQpddkKWKWIK----NQYQPCER 81  Caenorhabditis rem...
Feature 1                                        #  #               ##                        
4A04_A     91 ADpat---pgRVHYHpdsPAKGAqWMKQIVSFDKlKLTNNlld---dnGHIILnSMHRYQPRFHVVYvdprkdsekyaee 164 human
Q9NA56     80 RHatkkeqeiKYFLHpdgTKLGKeLMKETIKFDTvRITNHkkfm-dkdNVFFVeTMHKYVPVLTVKNitnv-------es 151 Caenorhabditis ele...
NP_508304  91 SEipm--edtEEIVHldgYQTGArWMKTGVYFPKiGISKEqpd---keRCLLLeSLHAYVPVLRFTTssgis-----lev 160 Caenorhabditis ele...
POM34953  195 RKaapl-ylnREVSHkdgVKTGKeWMSEXIKFDEvRITNNksne-skdNFIFTeTMHLYRPVITFKNidp--------tk 264 Caenorhabditis rem...
Q9N2K7     81 RKpkph-hnmKFFFHpegTKLGKeLMAETVEFTSvRITTSekls-ekeNVFYVhTMHKYVPVLTIRNlttg-------ei 151 Caenorhabditis ele...
OZG18313   79 RNskdt-hpyKSINHpdgIQTGEyWRSHPIEFDHlRITSKvdlekkdeNVLFVrTMYRYVAVLTVNDln----------s 147 Caenorhabditis latens
Q9NAH2     73 STknsklsaiTETEHr--KETGAtWNMRIVQFDKlLITREfnd--iqrNVIHVePNHKYIPVLTIQNvtt---------g 139 Caenorhabditis ele...
EGT34759   75 ASrna--rscKCSTSetpKEAGStWNEIIVKFEKlRITRElse--irqNVIYVePNHKYIPILSIINtst---------g 141 Caenorhabditis bre...
EGT40516   84 AYvie---plKRVFHeagVKTGEkWMYENVSFNFvRLTNDvdd--edpRKIFLkPCQMYTPVLTIYEctpqg----tikk 154 Caenorhabditis bre...
POM52008   82 PDnie--cvsRTINHwkgQQKGSwWMKNNVDFNYiQLTSRtyqe-dypDMIRLqRCFKYIPVLNIFEne----------q 148 Caenorhabditis rem...
Feature 1                    ####    #  ##  #
4A04_A    165 nFKTFVFEETRFTAVTAYQNHRITQLKIASN 195 human
Q9NA56    152 aNHSMRMEVAQFFPVTVYNQESIGNWKSKFH 182 Caenorhabditis elegans
NP_508304 161 tVWSQKFVTTMTSSNRSVKRREKRKLEETTG 191 Caenorhabditis elegans
POM34953  265 sPIYHSDPLFNFIPVTIYQHTSIGKWKAKNN 295 Caenorhabditis remanei
Q9N2K7    152 aSNIFKMEIAQFFPVSIYQQASMGRWKSDLN 182 Caenorhabditis elegans
OZG18313  148 gPIRTMIHTAQFIPVSVYQDSTIGRWKSQYN 178 Caenorhabditis latens
Q9NAH2    140 kSTEFQFQQMEFIAVKSYQSARIRHTKRAPR 170 Caenorhabditis elegans
EGT34759  142 vSVDFRFDLLQFVAVKSFHSIAIRHAKRSTR 172 Caenorhabditis brenneri
EGT40516  155 pHFEFRVRHTEFIAVNKMKSRKMLAFKKNSN 185 Caenorhabditis brenneri
POM52008  149 lIHAARLEHTEFIAVHTINNRQLKDLKRHIR 179 Caenorhabditis remanei

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